This review explores various catalytic strategies for achieving diverse diastereomeric outcomes in asymmetric conjugate additions creating carbon–carbon bonds.
The asymmetric catalytic synthesis of 1,2-diamines has received considerable interest, due to their presence in biologically active compounds and their applications for the development of synthetic building blocks, chiral ligands and organocatalysts.
Diastereodivergent and asymmetric [4 + 2] annulations between cyclic 1,3-dienes and 1-azadienes via ligand-controlled Pd catalysis have been realized, furnishing both cis- and trans-fused tetrahydropyridines in good yields and stereoselectivity levels.
A solvent- and temperature-controlled diastereodivergent [4+2] cyclization between para-quinone methides (p-QMs) and 4-benzylidene-pyrazolones has been developed.
Base-catalyzed diastereodivergent thia-Michael addition to chiral β-trifluoromethyl-α,β-unsaturated N-acylated oxazolidin-2-ones leading to a series of chiral thia-Michael adducts in good yields with high diastereoselectivities is described.