This review focuses on fluorescence mechanisms for viscosity responsiveness, highlighting some important probes like coumarin, BODIPY, and xanthene as well as the application of these viscosity-sensitive probes for successful diabetes detection.
Mitochondrial viscosity plays a pivotal role in the microenvironment of mitochondria and is closely associated with pathological conditions.
The study designed a mitochondria-targeted probe PMI-MT using TICT mechanism. It detected viscosity changes in HepG2 cells' mitochondria under drugs and visualized real-time viscosity alterations in inflammatory zebrafish.
A novel mitochondrial targeting mitochondrial membrane potential-independent near-infrared fluorescent probe, ACR-DMA, was developed which can be firmly immobilized in mitochondria for tracking of mitochondrial viscosity changes in vitro and in vivo.
We have constructed a novel fluorescent probe GX-VS for detecting viscosity in vitro and in vivo.