The applications of 2-hydroxy-β-nitrostyrenes as efficient bifunctional intermediates for the asymmetric synthesis of chromans, chromenes, coumarins, benzofurans, natural products, and other cyclic and acyclic compounds were reviewed in this paper.
The heterogeneous N-primary amine tetrapeptide can efficiently catalyze asymmetric Michael addition of both α-unbranched and α-branched aldehydes to nitroolefins in high yields with excellent enantioselectivities and diastereoselectivities.
A highly efficient, catalyst-free, metal-free, atom economical green protocol for the synthesis of arylthio/arylamino methylene compounds from nitroolefins derived from acenaphthaquinone and isatin has been developed.
A highly enantioselective Michael addition is developed by the addition of 3-hydroxy-2-pyridone to nitroolefins using cinchona-derived bifunctional organocatalysts.
A series of oxazole-fused succinimides bearing vicinal quaternary carbon centers were synthesized via catalytic asymmetric Michael addition and Nef-type sequential reactions of nitroolefins with azlactones.