Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Muhammad Wasim and Maria Camilla Bergonzi

Pharmaceutics, 2024, 16, 692
DOI: 10.3390/pharmaceutics16060692

Quercetin Modulates Ferroptosis via the SIRT1/Nrf−2/HO−1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model

Hongri Ruan, Tingting Zhu, Tiantian Wang, Yingchao Guo, Yun Liu and Jiasan Zheng

IJMS, 2024, 25, 7461
DOI: 10.3390/ijms25137461

Echinatin alleviates sepsis severity through modulation of the NF-κB and MEK/ERK signaling pathways

Meina Duan, Jing Jie, Chunxiuli Li, Xiaoxue Bai, Shucheng Hua, Mingbo Tang and Dan Li

Biomedicine & Pharmacotherapy, 2024, 179, 117359
DOI: 10.1016/j.biopha.2024.117359

Yiqi Liangxue Jiedu Prescription Inhibited the Canonical Wnt Pathway to Prevent Hepatocellular Precancerous Lesions

Yuling Liang, Yuqing Xie, Zhibo Dang, Mengge Li, Lihua Yu, Xinhui Wang, Peng Wang and Zhiyun Yang

JHC, 2024, Volume 11, 2293
DOI: 10.2147/JHC.S485257

Short-term high-fat diet post-ACLT surgery activates chondrocyte AMPK pathway and slows articular cartilage degeneration in rats

Hongri Ruan, Tingting Zhu, Tianwen Ma, Yun Liu and Jiasan Zheng

Journal of Functional Foods, 2025, 124, 106609
DOI: 10.1016/j.jff.2024.106609

Prevention and treatment of knee osteoarthritis by natural products: potential mechanisms based on articular cartilage targets

Qitao Ye, Kangyu Zhou, Qingqi Gao, Chengyan Li, Yunjie Sheng, Li Zou, Chaoying Tong and Dan Shou

Chinese Journal of Natural Medicines, 2026, 24, 129
DOI: 10.1016/S1875-5364(26)61097-7

Oleanolic acid-based nanoparticles for the treatment of ulcerative colitis

Dan Zhang, Beiwei Zhu, Yu Xu, Fengxian Luo, Tao Chen, Lihang Chen, Xinchuang Wang, Di Wu and Jiangning Hu

Nanomedicine, 2025, 20, 677
DOI: 10.1080/17435889.2025.2467019

Hyaluronic acid-based reduction responsive nanoparticles for Improved anti-psoriasis effects of traditional Chinese herb monomer oleanolic acid via blocking YAP-AREG axis

Ying Han, Junjie Ren, Yue Su, Linzhu Zhou, Xinyuan Zhu, Zejian Wang, Fei Kong and Guolin Li

J Nanobiotechnol, 2026, 24
DOI: 10.1186/s12951-026-04264-x

Single-cell RNA sequencing reveals different chondrocyte states in femoral cartilage between osteoarthritis and healthy individuals

Zewen Sun, Mingyue Yan, Junjie Wang, Haoyun Zhang, Xiaobin Ji, Yujing Xiao, Tianrui Wang and Tengbo Yu

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1407679

Natural synergy: Oleanolic acid-curcumin co-assembled nanoparticles combat osteoarthritis

Chen Liu, Wanchun Du, Liang Zhang and Jiacheng Wang

Colloids and Surfaces B: Biointerfaces, 2025, 245, 114286
DOI: 10.1016/j.colsurfb.2024.114286

Wine‐Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization

Yongsheng Fu, Minghua Zhao, Xudong Huang, Yingchao Ren and Weiguo Wang

J Cellular Molecular Medi, 2026, 30
DOI: 10.1111/jcmm.71113

Melatonin Improves Diabetic‐Accelerated Experimental Osteoarthritis by Inhibiting NLRP3‐Mediated Chondrocyte Pyroptosis via PKG/Nrf2

Wenyue Yang, Hong Chen, Yukun Zhang, Shuya Wang, Xue Miao, Zongsheng Qiu, Di Qiu, Bo Gu, Luyao Zhang, Jiantao Zhang and Tianwen Ma

Journal of Pineal Research, 2026, 78
DOI: 10.1111/jpi.70113

SFRP4 Regulates Chondrocyte Hypertrophy and Apoptosis via Wnt/Ca2+ and Wnt/JNK Pathways in Steroid‐Induced Osteonecrosis of the Femoral Head

Hongfan Ge, Xiaoli Fan, Yixin Jiang, Xueting Zhang, Xingkai Zhao and Zhenlei Zhou

Comprehensive Physiology, 2025, 15
DOI: 10.1002/cph4.70052

LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis

Fudong Li, Yangyang Shi, Jun Chen, Jingchuan Sun, Jiangang Shi, Kaiqiang Sun and Bing Zheng

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06427-0

IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m6A/MMP3 Axis

Ziqin Zhao, Shuhui Dong, Yong Yang, Haibo Yin, Guangyi Xiong and Jianxiong Ma

IJGM, 2024, Volume 17, 2433
DOI: 10.2147/IJGM.S463734

Milk fat globule-epidermal growth factor 8 exerts anti-osteoarthritis effects by inhibiting apoptosis and inducing autophagy in mouse chondrocytes

Yang Gao, Jian Feng, Qiang Chen, Zhe Wang and Zhihua Yang

Biochemical and Biophysical Research Communications, 2024, 741, 151022
DOI: 10.1016/j.bbrc.2024.151022

Therapeutic targets in aging-related osteoarthritis: A focus on the extracellular matrix homeostasis

Wan Hao, Minnan Chang, Di Shi, Chenxi Yun, Jun Li, Haitao Guo and Xiao Lin

Life Sciences, 2025, 368, 123487
DOI: 10.1016/j.lfs.2025.123487

Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress: Comprehensive Review Across Compound Classes and Experimental Systems

Alexey Koval, Nilufar Z. Mamadalieva, Rano Mamadalieva, Fazliddin Jalilov and Vladimir L. Katanaev

Antioxidants, 2025, 14, 591
DOI: 10.3390/antiox14050591

FBXW7 promotes osteoarthritis injury by regulating SLC7A11 ubiquitination degradation and chondrocyte ferroptosis

Lijuan Yang, Dongli Wang, Nan Yu and Caixia Zhu

Pathology - Research and Practice, 2026, 277, 156297
DOI: 10.1016/j.prp.2025.156297

Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis

Fanchen Wang, Jiacong Xiao, Miao Li, Qi He, Xintian Wang, Zhaofeng Pan, Shaocong Li, Haibin Wang, Chi Zhou and Zhifeng Yu

PLoS ONE, 2024, 19, e0308731
DOI: 10.1371/journal.pone.0308731

The Hippo-YAP Signaling Pathway in Osteoarthritis and Rheumatoid Arthritis

Min Li, Fang-Jie Zhang and Rui-Jun Bai

JIR, 2024, Volume 17, 1105
DOI: 10.2147/JIR.S444758

Wedelolactone alleviates inflammation and cartilage degeneration by suppressing the NF-κB signaling pathway in osteoarthritis

Weichao Sun, Jiaji Yue, Yinxing Cui, Jianguo Feng, Qifei He, Jianhui Liang, Wei You, Houyin Shi, Wei Sun and Qian Yi

International Immunopharmacology, 2024, 143, 113359
DOI: 10.1016/j.intimp.2024.113359

The Sanbi Decoction alleviates intervertebral disc degeneration in rats through intestinal flora and serum metabolic homeostasis modulation

Nan Wang, Shuang Chen, Yimin Xie, Xin Liu, Zhipeng Xi, Jingchi Li, Congyang Xue, Rongrong Deng, Wen Min, Ran Kang and Lin Xie

Phytomedicine, 2024, 127, 155480
DOI: 10.1016/j.phymed.2024.155480

Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders

Juanjuan Han, Jiale Zhang, Xiaoyi Zhang, Wenxin Luo, Lifei Liu, Yuqing Zhu, Qingfeng Liu and Xin-an Zhang

Stem Cell Res Ther, 2024, 15
DOI: 10.1186/s13287-024-04011-9