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Machine learning-guided protein engineering to improve the catalytic activity of transaminases under neutral pH conditions

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Photochemical deracemization of 2,3-allenoic acids mediated by a sensitizing chiral phosphoric acid catalyst

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Exploring lipase regioselectivity: synthesis of regioisomeric acetoxyhydroxynaphthalenes

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Cascade biocatalysis for enantioselective reconstruction of both enantiomers of phenylalaninol from biobased l-phenylalanine

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Recent advances in repurposing natural enzymes for new-to-nature asymmetric photobiotransformations

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Chemoenzymatic synthesis of Tamsulosin

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Protein dynamics-assisted engineering of a selective debenzylase for replacing Pd/C-catalyzed debenzylation in statin precursor synthesis

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Engineering anisotropic wettability in metal–organic framework composites for advanced multiphase-interfacial biocatalysis

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Engineered amine oxidase for efficient oxidative dehydroaromatization of 1,2,3,4-tetrahydroquinolines toward quinolines in aqueous media

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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

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Biocatalytic Stereodivergent Construction of Axially Chiral Tri- and Tetrasubstituted Allenols via Desymmetric Hydroxylation

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Hydrophobic interaction-assisted immobilization of molecular catalysts into organic colloids: From organic synthesis in water to mimicking enzymes

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Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

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Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides

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Co‐Confinement of Enzymes and Cofactors Within Pickering Droplet Derived Microreactors for Continuous Flow Catalysis

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Understanding the Enzymatic Synthesis of a New Biolubricant: Decane-1,10-diyl bis(2-methylpentanoate)

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A Review of Guerbet Alcohols and Their Esters: Synthesis, Applications, and Future Perspectives

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Genomic Functional Analysis and Cellulase Characterization for the Enzyme-Producing Strain Bacillus subtilis Y4X3 Isolated from Saline–Alkaline Soil in Xinjiang, China

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Exploiting unique NP1 interface: Oriented immobilization via electrostatic and affinity interactions in a tailored PDA/PEI microenvironment enhanced by concanavalin A

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An Electroenzymatic Platform toward Enantioenriched α-Chloro- and α,α-Dichloro β-Hydroxy Esters

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Chemogenetic Evolution of Diversified Photoenzymes for Enantioselective [2 + 2] Cycloadditions in Whole Cells

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Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N‐Heterocycles

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Harnessing the power of microbial consortia for the biodegradation of per- and polyfluoroalkyl substances: Challenges and opportunities

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Enhancing the stability and activity of enzymes through layer-by-layer immobilization with nanocomposite hydrogel

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Identification of novel metagenomic lipases through integrated structural and sequence-based analysis

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Single‐Electron Oxidation Triggered by Visible‐Light‐Excited Enzymes for Asymmetric Biocatalysis

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Use of Nicotinamide Mononucleotide as Non-Natural Cofactor

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Enzymes as Catalysts in Industrial Biocatalysis: Advances in Engineering, Applications, and Sustainable Integration

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Alternative Dehydrogenases to Address Glucose Dehydrogenase Cross‐Reactivity During NADPH Regeneration

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Recent Advances in Biocatalytic Dearomative Spirocyclization Reactions

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Kinetic Hydrolysis of Sulfinamides toward S(IV) Chirality Enabled by Visible-Light-Excited Ene-Reductases

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Synthesis of Chiral Sulfinamides Enabled by Polycyclic Ketone Monooxygenase Catalyzed Asymmetric Oxidation of Sulfenamides

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Expanding biocatalytic reactivity landscapes by physical fields and chemical strategies for green manufacturing

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A Biocatalytic Platform for the Synthesis of Organofunctional Silanes and Siloxanes

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Recent Advances in Protein Engineering and Synthetic Applications of Amino Acid Transaminases

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Merging Au(I)-Catalysis and Biocatalysis: Practical and Scalable Synthesis of Chiral Amino Building Blocks from Alkynes

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Engineered Biocatalyst for Enantioselective Hydrazone Reduction

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P450 engineering via structure-guided rational design achieves high C21-selectivity and bioconversion in steroid biosynthesis

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Improving the Phosphatase-Catalyzed Synthesis of 5′-Nucleotides: A Reaction Engineering Approach

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Closed-loop peroxide supply strategy: Engineering photo-nanozyme cascade systems for ultrafast degradation of mycotoxins in water

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Leveraging histidine-nickel coordination for stable enzyme immobilization on metal-organic frameworks

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A Chemoselective and Stereodivergent Platform of Heme‐Nitrene Transferases to Access Chiral Aryl‐β‐Amino Esters and An Investigation of the Sequence‐Activity Landscape

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Biocatalytic Activation of Sulfur Heteroaromatics Facilitates Dearomatizing Cross-Couplings to Set Stereogenic Centers or Axes

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J. Am. Chem. Soc., 2025
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Synthesis of Planar Chiral [2.2]Paracyclophanes via Biocatalyzed Desymmetrization of Primary Alcohols

Daniel Alonso, Nahia Egaña, Enrique Gómez-Bengoa and Rosa López

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The Impact of Continuous Flow Technology and Collaboration between Academia and Industry

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Update: Enzymatische Synthese für industrielle Anwendungen

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Recent Applications of Albumin as a Green and Versatile Catalyst in Organic Synthesis

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Molecules, 2025, 30, 4168
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Rapid Development of a Scalable Reduction of R-Carvone Utilizing Commercially Available Biocatalysts

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Enantioselective energy transfer catalysis compartmentalized by triplet photoenzymes

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A comprehensive review on the enantiomeric separation of chiral drugs using metal-organic frameworks

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Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N‐Heterocycles

Adam O'Connell, Marianne B. Haarr, James Ryan, Xingxing Xu, Aoife Martin, Simon N. Smith, Nadia Elghobashi‐Meinhardt, Patricia Fleming, Beatriz Maciá, Vittorio Caprio and Elaine O'Reilly

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Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability

Ben Ashley, Sam Mathew, Mariyah Sajjad, Yaoyi Zhu, Nikita Novikovs, Arnaud Baslé, Jon Marles-Wright and Dominic J. Campopiano

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Genetically modified lipases as biocatalysts for diacylglycerol production in the food industry: a critical review

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Engineering Imine Reductase for the Synthesis of Pharmaceutically Relevant 1-Aminomethylbenzocycloalkanes via Dynamic Kinetic Resolution–Asymmetric Reductive Amination

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Hydrogen Sulfide‐Triggered Artificial DNAzyme Switches for Precise Manipulation of Cellular Functions

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Accelerated adhesion of immobilized on electrophilic interface modified by co-deposition of dopamine and chitosan

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A Chemoselective and Stereodivergent Platform of Heme‐Nitrene Transferases to Access Chiral Aryl‐β‐Amino Esters and An Investigation of the Sequence‐Activity Landscape

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5th International Symposium on Synthesis and Catalysis (ISySyCat2023)

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Machine learning-assisted protein engineering for improving stereoselectivity

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Enantioselective biosynthesis of vicinal diamines enabled by synergistic photo/biocatalysis consisting of an ene-reductase and a green-light-excited organic dye

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Enzyme symphony in bio-inspired multi-enzyme cascades for enhanced biosynthesis

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Biocatalytic Synthesis of Corticosteroid Derivatives by Toad-Derived Steroid C21-Hydroxylase

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Recent Advances in Catalytic Approaches for Pyrano[2,3‐c]Pyrazole Synthesis: Green and Sustainable Perspectives

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Direct Microplate Sampling Mass Spectrometry for High-Throughput Screening of Biocatalytic Activity

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Expanding the role of biocatalysis in green chemistry: Lessons from the past, directions for the future

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Divergent Protein Engineering of Transaminase for the Synthesis of Chiral Rivastigmine and Apremilast Precursors†

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Single‐Electron Oxidation Triggered by Visible‐Light‐Excited Enzymes for Asymmetric Biocatalysis

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Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson and David B. Berkowitz

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Kinetic Resolution to Simultaneously Access Both Primary and Secondary NH-Unprotected Chiral Amines via Ir-Catalyzed Asymmetric Reductive Amination

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Catalysis for micro/nanorobots

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Enantiodivergent synthesis of axially chiral alkylidene cyclohexylamines by imine reductases-catalyzed desymmetrization

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Construction of a stable manganese/copper core-shell laccase-like enzyme for recyclable dye decolorization and phenolic pollutant detection

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Behavior of the Bionanoreactor with Coencapsulated Cofactors and Enzymes in HOF-101 for Cascade Chiral Amine Synthesis

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Hydroxyapatite: An Eco‐Friendly Material for Enzyme Immobilization

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Production of Value-Added Arabinofuranosyl Nucleotide Analogues from Nucleoside by an In Vitro Enzymatic Synthetic Biosystem

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Biocomposites of Enzymes and Covalent Organic Frameworks: A Novel Family of Heterogenous Biocatalysis

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Subtilisin: a bibliometric and comprehensive review of its structure, production, and versatile applications

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Commercial Transaminases for the Asymmetric Synthesis of Bulky Amines

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Single‐Atom Skeletal Editing of Aromatics: Advances in Carbon‐to‐Nitrogen and Nitrogen‐to‐Carbon Transmutation

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Self-Assembly of Benzyloxycarbonyl Histidine with Zinc Ions for the Construction of Esterase Mimics

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Engineering LmrR protein for L-proline-based asymmetric aldol biocatalysis

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NAD(P)‐Dependent Glucose Dehydrogenases: Underestimated Multifunctional Biocatalysts

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Generative artificial intelligence for enzyme design: Recent advances in models and applications

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Asymmetric synthesis of chiral N-substituted amino amides and esters with two chiral centers by imine reductase-catalyzed dynamic kinetic resolution via reductive amination

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Activity Modulation of an Enzyme in a Confined Space

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Waste Valorization in a Sustainable Bio‐Based Economy: The Road to Carbon Neutrality

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Hydrogen Sulfide‐Triggered Artificial DNAzyme Switches for Precise Manipulation of Cellular Functions

Xuan Xie, Hexin Nan, Jialong Peng, Kaiqiang Zeng, Hong‐Hui Wang, Yan Huang and Zhou Nie

Angew Chem Int Ed, 2024, 63
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Photoinduced Ene‐Reductase Catalysis via Electron Donor–Acceptor Complexes

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ChemBioChem, 2025, 26
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Unlocking enzymatic deracemization of structurally diverse allenes by designed photoenzymes

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Nat Commun, 2026, 17
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Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis

Ge Qu, Fangrui Zhong, Jian Xu, Xiaoqiang Huang and Zhoutong Sun

Green Synthesis and Catalysis, 2026, 7, 157
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An Update: Enzymatic Synthesis for Industrial Applications

Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius and Uwe T. Bornscheuer

Angew Chem Int Ed, 2025, 64
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Selective Oxidation of Disparate Functional Groups Mediated by a Common Aspartic Acid-Based Peptide Catalyst Platform

Susannah E. Huth, Elizabeth A. Stone and Scott J. Miller

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Enzyme‐Catalyzed Efficient Synthesis of Enantiomerically Pure (S)‐ and (R)‐n‐Butylphthalide

Keming Song, Jianing Li, Xiaoyan Zhang, Liliang Chu, Peiwen Liu, Zhiwen Lu, Hui Wu and Yunpeng Bai

ChemBioChem, 2025, 26
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Embedding Pd-like ZrO and NbN superatoms into fullerenes: An intriguing strategy to achieve chainmail catalysts

Zhi-Chao Zhang, Wei-Huang Wang, Ting Wu and Wei-Ming Sun

Inorganic Chemistry Communications, 2025, 182, 115413
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Activation of diterpene hydrocarbon skeletons by microbial natural P450 oxidases

Jiaxing Li, Yaxin Dai, Xiao Chen, Qibin Chen, Fen-Er Chen, Qi Zhang and Jie Gao

Green Synthesis and Catalysis, 2025
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An overview of additive manufacturing strategies of enzyme-immobilized nanomaterials with application incatalysis and biomedicine

Ankur Sood, Sabya Sachi Das, Ritu Singhmar, Sumanta Sahoo, Muhammad Wahajuddin, Zaiba Naseem, Soonmo Choi, Anuj Kumar and Sung Soo Han

International Journal of Biological Macromolecules, 2025, 292, 139174
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Biocatalysis in medicinal chemistry: sustainable enzymatic transformations for drug synthesis

David A. Undie, Francis A. Ibekwe, Humphrey S. Samuel, Onimisi P. Onotu, Oluwakemi O. Akinpelu and Emmanuel E. Etim

Discov. Chem., 2025, 2
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Co‐Confinement of Enzymes and Cofactors Within Pickering Droplet Derived Microreactors for Continuous Flow Catalysis

Min Fan, Changhao Wang and Hengquan Yang

Angewandte Chemie, 2026
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A Comprehensive Guide to Enzyme Immobilization: All You Need to Know

Marina Simona Robescu and Teodora Bavaro

Molecules, 2025, 30, 939
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Directed Evolution of Nonheme Iron Enzymes for Enantioselective Aminative Difunctionalization of Alkenes

Fei Liu, Si-Yi Li, Zi-Shan Fan, Jia-Hua Luo, Xue Zeng, Long Wei, Ye Li, Jia-Yao Li, Yongxiang Zheng, Xin Wang, Chun Zhang, Peng Chen and Zhi-Jun Jia

JACS Au, 2025, 5, 4472
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Engineering an Imine Reductase for Enantioselective Synthesis of Atropisomeric Amides

Zhouchang Yao, Runze Meng, Zitian Zhou, Luyao Yu, Zhiyun Wu, Longqing Tang, Tianzhang Qiao, Ke Li, Ling Huang, Danqing Song and Haigen Fu

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Engineered Biocatalyst for Enantioselective Hydrazone Reduction

Amy E. Hutton, Fei Zhao, Elizabeth Ho, Jack Domenech, Vanessa Harawa, Murray J. B. Brown, Gideon Grogan, Phillip D. Clayman, Nicholas J. Turner and Anthony P. Green

Angew Chem Int Ed, 2025, 64
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Kinetic and biocatalytic evaluation of dodecyl nicotinate hydrolysis in aqueous buffers and biological media

Razan Haddad, Bashar Al‑Taani, Aliaa Al‑Tarakji and Nasr Alrabadi

Drug Development and Industrial Pharmacy, 2026, 52, 602
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A Biocatalytic Platform for the Synthesis of Organofunctional Silanes and Siloxanes

Ziyan Zhang, Tyler J. Fulton, Ryan R. Maar, John M. Roberts, Dimitris E. Katsoulis and Frances H. Arnold

Angew Chem Int Ed, 2026, 65
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Smart Hydrogel Doped by Metal–Organic Frameworks for Renewable Self‐Pumping Enzymatic Reactors

Yuxi Zhu, Shenghao Wang, Yueyuan Luo, Linbo Cao, Xiuxiu Guo, Yue Zhang, Mingmin Li and Tie Wang

Advanced Science, 2026, 13
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Excellent Laccase Mimic Activity of Cu-Melamine and Its Applications in the Degradation of Congo Red

Siyuan Chai, Enze Huang, Jiashuai Zeng, Yangyang Shi, Jiashuo Zhang and Xia Zhang

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Enhancing Sustainable Energy Through Cutting-Edge Waste Biorefinery Technologies

Yen-Yi Lee, Masimukku Srinivaas, I-Cheng Li, Kapa Keharika, Ramyakrishna Pothu, Rajender Boddula, Noora Al-Qahtani, Bo-Wun Huang and Guo-Ping Chang-Chien

Reactions, 2024, 5, 1101
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A novel directed evolution approach for co-evolution of β-glucosidase activity and organic acid tolerance

Bei Ouyang, Guoping Wang, Ziyan Hu, Qiling Liu, Wenwen Zhao and Xihua Zhao

Journal of Biotechnology, 2025, 401, 1
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Porousizing catalysts for boosting CO2 electroreducation

Xiaoyu You, Caoyu Yang, Xinwei Li and Zhiyong Tang

Chinese Journal of Catalysis, 2024, 67, 4
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Scalable and sustainable synthesis of chiral amines by biocatalysis

Matthew J. Takle, David M. Maurer, Philipp Staehle, Joachim Dickhaut, Christian Holtze, Klaus Hellgardt and King Kuok Mimi Hii

Commun Chem, 2025, 8
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Ancestral Sequence Reconstruction for Designing Biocatalysts and Investigating their Functional Mechanisms

Kridsadakorn Prakinee, Suppalak Phaisan, Sirus Kongjaroon and Pimchai Chaiyen

JACS Au, 2024, 4, 4571
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