Autonomous reaction self-optimization using in-line high-field NMR spectroscopy

Nour El Sabbagh, Margherita Bazzoni, Yuliia Horbenko, Aurélie Bernard, Daniel Cortés-Borda, Patrick Giraudeau, François-Xavier Felpin and Jean-Nicolas Dumez

React. Chem. Eng., 2024, 9, 2599
DOI: 10.1039/D4RE00270A

Continuous flow synthesis of the antiviral drug tecovirimat and related sp3-rich scaffolds

Arlene Bonner and Marcus Baumann

Org. Biomol. Chem., 2024, 22, 8323
DOI: 10.1039/D4OB01379D

Solvent-free synthesis of chalcones using Mg(HSO4)2

Ervis Saraci, Massimiliano Andreoli, Emanuele Casali, Massimo Verzini, Maria Argese, Roberto Fanelli and Giuseppe Zanoni

RSC Sustainability, 2023, 1, 504
DOI: 10.1039/D3SU00003F

A cyanide-free synthesis of nitriles exploiting flow chemistry

Niamh Disney, Megan Smyth, Scott Wharry, Thomas S. Moody and Marcus Baumann

React. Chem. Eng., 2024, 9, 349
DOI: 10.1039/D3RE00458A

Construction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol

Chao Shan, Liming Cao, Jiasheng Yang, Ruihua Cheng, Xiantong Yao, Chaoming Liang, Maolin Sun and Jinxing Ye

React. Chem. Eng., 2022, 7, 1779
DOI: 10.1039/D2RE00145D

Systematic study of FFF materials for digitalizing chemical reactors with 3D printing: superior performance of carbon-filled polyamide

Victoria A. Korabelnikova, Evgeniy G. Gordeev and Valentine P. Ananikov

React. Chem. Eng., 2023, 8, 1613
DOI: 10.1039/D2RE00395C

Will the next generation of chemical plants be in miniaturized flow reactors?

Jean-Christophe M. Monbaliu and Julien Legros

Lab Chip, 2023, 23, 1349
DOI: 10.1039/D2LC00796G

The role of PAT in the development of telescoped continuous flow processes

Aoife M. Kearney, Stuart G. Collins and Anita R. Maguire

React. Chem. Eng., 2024, 9, 990
DOI: 10.1039/D3RE00678F

An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans

Zhining Li, Shiqi Huang, Yuan Tao, Meifen Jiang, Dang Cheng, Li Wan and Fener Chen

React. Chem. Eng., 2023, 8, 1882
DOI: 10.1039/D3RE00082F

A cascade Markovnikov addition/Lewis acid-catalyzed rearrangement of methyleneaziridines and carboxylic acids: continuous-flow synthesis of α-amidoketones

Bin Pan, Hao-Tian Sun, Feng Li, Qing-Bao Zhang, Shan-Shan Zhang, Jia-Hao Wang, Meng-Rui Xu, Jing-Tian Ge, Zi-Qing Hu, Shang Lv, Guo-Fu Huang and Li-Juan Feng

Org. Chem. Front., 2025, 12, 5168
DOI: 10.1039/D5QO00495K

Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

Diana V. Silva-Brenes, Shailesh Agrawal, Vilmalí López-Mejías, Jorge Duconge, Cornelis P. Vlaar, Jean-Christophe M. Monbaliu and Torsten Stelzer

React. Chem. Eng., 2024, 9, 2728
DOI: 10.1039/D4RE00273C

Efficient construction of a β-naphthol library under continuous flow conditions

Chao Shan, Ranran Li and Xinchao Wang

RSC Adv., 2024, 14, 2673
DOI: 10.1039/D3RA08660G

Inline purification in continuous flow synthesis – opportunities and challenges

Jorge García-Lacuna and Marcus Baumann

Beilstein J. Org. Chem., 2022, 18, 1720
DOI: 10.3762/bjoc.18.182

Scaled up and telescoped synthesis of propofol under continuous-flow conditions

Guilherme M. Martins, Maria F. A. Magalhães, Timothy J. Brocksom, Vanderlei S. Bagnato and Kleber T. de Oliveira

J Flow Chem, 2022, 12, 371
DOI: 10.1007/s41981-022-00234-0

Continuous Flow Technology Enabling Photochemistry

Ruairi Crawford and Marcus Baumann

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202500133

Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa

Clinton G. L. Veale, John G. Woodland, Kathryn J. Wicht and Kelly Chibale

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202419681

Continuous flow Friedel–Crafts acetylation of phenols and electron-rich arenes and heteroarenes

Kévin Saint-Jacques and André B. Charette

J Flow Chem, 2023, 13, 193
DOI: 10.1007/s41981-023-00270-4

Advances in the Continuous Flow Synthesis of 3‐ and 4‐Membered Ring Systems

Kian Donnelly and Marcus Baumann

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400758

Polyetheretherketone fiber-supported TBD as an efficient fibrous superbase catalyst for organic conversions in continuous-flow processing

Xian-Lei Shi, Yue Lv, Tian Zhang, Qianqian Hu, Keren Shi, Wenqin Zhang and Zhenhua Li

Journal of Catalysis, 2023, 418, 110
DOI: 10.1016/j.jcat.2023.01.010

Process Intensification and Increased Safety for the On-Demand Continuous Flow Synthesis of Dithiothreitol, a Crucial Component in Polymerase Chain Reaction Testing Kits

Maryne A. J. Dubois, Virginie Carreras, Matt R. Adams, Vanessa Kairouz, Jean-François Vincent-Rocan, John G. Riley and André B. Charette

Org. Process Res. Dev., 2023, 27, 227
DOI: 10.1021/acs.oprd.2c00345

Preparation of glycoside precursors in flow from food flavours containing a phenolic hydroxyl group

Jinzhong Hu, Yang Xu, Tianqi Lu, Jian Chen, Zhuoer Cai, Xiang Zhang, Min Liu, Xiaodong Shen and Baiwang Sun

Chem. Pap., 2024, 78, 463
DOI: 10.1007/s11696-023-03102-w

Robotics and Aseptic Processing in View of Regulatory Requirements

Andrea Tanzini, Marco Ruggeri, Eleonora Bianchi, Caterina Valentino, Barbara Vigani, Franca Ferrari, Silvia Rossi, Hermes Giberti and Giuseppina Sandri

Pharmaceutics, 2023, 15, 1581
DOI: 10.3390/pharmaceutics15061581

Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa

Clinton G. L. Veale, John G. Woodland, Kathryn J. Wicht and Kelly Chibale

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202419681

Reshaping Chemical Manufacturing Towards Green Process Intensification: Recent Findings and Perspectives

Giancarlo Cravotto

Processes, 2025, 13, 459
DOI: 10.3390/pr13020459

Utilizing metal-organic frameworks and covalent-organic frameworks for enhanced cathode design and separator functionality in metal-sulfur batteries

Xuexue Pan, Yi Zhao, Danyi Zhuang, Zhazira Supiyeva and Qamar Abbas

Journal of Energy Storage, 2026, 143, 119577
DOI: 10.1016/j.est.2025.119577

Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation

Haruro Ishitani, Hideyuki Sogo, Yuichi Furiya and Shu Kobayashi

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402128

Top 20 influential AI-based technologies in chemistry

Valentine P. Ananikov

Artificial Intelligence Chemistry, 2024, 2, 100075
DOI: 10.1016/j.aichem.2024.100075

A dynamic radial-based self-adaptive framework for modelling the Consigma-25 continuous tablet production line

Wafa’ H. AlAlaween, Riyadh B. Al-Asady and Agba D. Salman

Chemical Engineering Research and Design, 2025, 223, 634
DOI: 10.1016/j.cherd.2025.10.030

Microwave-assisted continuous flow synthesis of propofol

Cloudius R. Sagandira and Christophe Len

Sustainable Chemistry and Pharmacy, 2024, 42, 101793
DOI: 10.1016/j.scp.2024.101793

Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

Masaru Kondo, H. D. P. Wathsala, Mohamed S. H. Salem, Kazunori Ishikawa, Satoshi Hara, Takayuki Takaai, Takashi Washio, Hiroaki Sasai and Shinobu Takizawa

Commun Chem, 2022, 5
DOI: 10.1038/s42004-022-00764-7

Continuous Flow Synthesis of Nitrosoarenes via Photochemical Rearrangement of Aryl Imines

Jorge García-Lacuna and Marcus Baumann

J. Org. Chem., 2024, 89, 617
DOI: 10.1021/acs.joc.3c02362

Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes

Parth Naik, Jorge García-Lacuna, Patrick O’Neill and Marcus Baumann

Org. Process Res. Dev., 2024, 28, 1587
DOI: 10.1021/acs.oprd.3c00237

Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production

Alison J. Shapiro, Robert M. O'Dea, Sonia C. Li, Jamael C. Ajah, Garrett F. Bass and Thomas H. Epps,

Annual Review of Chemical and Biomolecular Engineering, 2023, 14, 109
DOI: 10.1146/annurev-chembioeng-101121-084152

Agile local manufacturing of active pharmaceutical ingredients in Africa could improve health security and economic growth

Cloudius Ray Sagandira

Commun Med, 2025, 5
DOI: 10.1038/s43856-025-01080-6

Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?

Mireia Rodriguez-Zubiri and François-Xavier Felpin

Org. Process Res. Dev., 2022, 26, 1766
DOI: 10.1021/acs.oprd.2c00102

FAQT-2: A customer-oriented method for MCDM with statistical verification applied to industrial robot selection

Hassan Soltan, Khaled Janada and Mohamed Omar

Expert Systems with Applications, 2023, 226, 120106
DOI: 10.1016/j.eswa.2023.120106

Efficient synthesis of m-terphenyl compounds in continuous flow utilizing organomagnesium

Chaoming Liang, Weixia Lin, Runxiang Yu, Yuyan Kang, Zilong Lin, Xiangmin Sang, Yueyue Ma, Ruihua Cheng, Maolin Sun and Jinxing Ye

J Flow Chem, 2025, 15, 161
DOI: 10.1007/s41981-025-00354-3

Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi and Hirokazu Sugiyama

Ind. Eng. Chem. Res., 2023, 62, 17824
DOI: 10.1021/acs.iecr.3c02137

Hybrid Lean Practices Integrated with IR 4.0 and Sustainability in Malaysia Food and Beverages Companies: Conceptual Framework and Hypothesis Development

Muslim Diekola Akanmu and Norshahrizan Nordin

JST, 2022, 30, 2271
DOI: 10.47836/pjst.30.3.29

Continuous flow synthesis of C-acyloxy-substituted aziridines in microchannel reactor: Addition of carboxylic acids to 2-methylenaziridines

Hao-Tian Sun, Bin Pan, Shan-Shan Zhang, Xian-Bin Su, Meng-Rui Xu, Zi-Qing Hu and Guang-Zhao Xu

Tetrahedron Letters, 2024, 138, 154982
DOI: 10.1016/j.tetlet.2024.154982

Telescoped Hybrid Batch–Flow Synthesis of 2-Butylbenzofuran

Fabiana Dedè, Cristina Ciancimino, Piero Danelli, Oreste Piccolo and Daniele Vigo

Org. Process Res. Dev., 2024, 28, 1783
DOI: 10.1021/acs.oprd.3c00378

Intelligent Chemical Synthesis in an Undergraduate Teaching Laboratory: Continuous Flow Synthesis of SNAr Reaction with Automated Robot-Assisted Condition Screening

Wenzhuo Xu, Haiyang Wang, Fujun Li, Leiyun Zhong, Wenbo Yang, Wenfeng Jiang, Shengyang Tao and Lijing Zhang

J. Chem. Educ., 2025, 102, 4033
DOI: 10.1021/acs.jchemed.4c01072

Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis

Zhexuan Lei, Hwee Ting Ang and Jie Wu

Org. Process Res. Dev., 2024, 28, 1355
DOI: 10.1021/acs.oprd.2c00374