A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging

Longqi Chen, Junjie Chen, Yichang Fang, Fang Zeng and Shuizhu Wu

Chem. Commun., 2021, 57, 7842
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A single-molecular ruthenium(ii) complex-based NIR-II fluorophore for enhanced chemo-photothermal therapy

Qianqian Li, Yishen Liu, Bingshan Zhao, Jiapeng Lei, Siyu Lu, Wanxia Gong, Ke Liang, Junzhu Wu, Xuechuan Hong and Yuling Xiao

Chem. Commun., 2022, 58, 6546
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A GLUTs/GSH cascade targeting-responsive bioprobe for the detection of circulating tumor cells

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Chem. Commun., 2022, 58, 3945
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The pursuit of polymethine fluorophores with NIR-II emission and high brightness forin vivoapplications

Xuan Zhao, Fan Zhang and Zuhai Lei

Chem. Sci., 2022, 13, 11280
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Supramolecular engineering cascade regulates NIR-II J-aggregates to improve photodynamic therapy

Huizhe Wang, Huijia Liu, Wenqing Li, Shuai Li, Jiaqi Zhang, Jingzhe Zang, Li Liu and Peng Wang

Chem. Sci., 2024, 15, 11347
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Mitochondria-targeted NIR-II organic probes for imaging–guided photodynamic therapy

Hui Zhou, Yuquan Ji, Siyang Yu, Jianhang Zhao, Fei Yu, Zhen Wang, Jiaqi Yuan, Xingkun Wang, Yunyi Hua, Jiao Li, Jun Wang, Chao Yin and Quli Fan

Chem. Commun., 2026, 62, 6642
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Near-Infrared multifunctional theranostic agent with Wave-Like aggregates modulated by substituent position effect

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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 271, 120881
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Alkyl-aryl styryl-indole dyes as fluorescent imaging and theranostic probes targeting mitochondria

Dijana Pavlović Saftić, Marta Domínguez-Prieto, Nicoleta Moisoi, Gea Lukić, Lucija Lulić Horvat, Jelena Puzić, Sandra Sobočanec, Marija Pinterić, Ivo Piantanida and Federico Brucoli

European Journal of Medicinal Chemistry, 2025, 297, 117974
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Mitochondria targeted fluorogenic theranostic agents for cancer therapy

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Preparation of NIR-Responsive Gold Nanocages as Efficient Carrier for Controlling Release of EGCG in Anticancer Application

Weiran Gao, Xiangyi Fan, Yunlong Bi, Zipeng Zhou and Yajiang Yuan

Front. Chem., 2022, 10
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Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging

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Journal of Luminescence, 2023, 263, 120099
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Recent advances in mitochondria‐targeting theranostic agents

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Exploration, 2024, 4
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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Yishen Liu, Yang Li, Seyoung Koo, Yao Sun, Yixuan Liu, Xing Liu, Yanna Pan, Zhiyun Zhang, Mingxia Du, Siyu Lu, Xue Qiao, Jianfeng Gao, Xiaobo Wang, Zixin Deng, Xianli Meng, Yuling Xiao, Jong Seung Kim and Xuechuan Hong

Chem. Rev., 2022, 122, 209
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Recent progress of second near-infrared (NIR-II) fluorescence microscopy in bioimaging

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Front. Physiol., 2023, 14
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Bichromatic Imaging with Hemicyanine Fluorophores Enables Simultaneous Visualization of Non-alcoholic Fatty Liver Disease and Metastatic Intestinal Cancer

Weijia Xu, Senyao Liu, Zhaoming Chen, Fapu Wu, Wenwen Cao, Yang Tian and Hu Xiong

Anal. Chem., 2022, 94, 13556
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A Renal-Clearable PEGylated Semiconducting Oligomer for the NIR-II Fluorescence Imaging of Tumor

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ACS Appl. Bio Mater., 2022, 5, 4965
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Molecular Engineering of Activatable NIR-II Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Inflammatory Bowel Disease

Yi Liu, Shanchao Diao, Bankang Ruan, Ya Zhou, Mengya Yu, Guoqi Dong, Weiping Xu, Lulu Ning, Wen Zhou, Yuyan Jiang, Chen Xie, Quli Fan and Jiaguo Huang

ACS Nano, 2024, 18, 8437
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Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

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Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives

Manja Kubeil, Irma Martínez, Michael Bachmann, Klaus Kopka, Kellie Tuck and Holger Stephan

Pharmaceuticals, 2022, 15, 432
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In vivo deep brain multiphoton fluorescence imaging emitting at NIR‐I and NIR‐II and excited at NIR‐IV

Jincheng Zhong, Yingxian Zhang, Xinlin Chen, Shen Tong, Xiangquan Deng, Jie Huang, Zhenhui Li, Chi Zhang, Zhiang Gao, Jia Li, Ping Qiu and Ke Wang

Journal of Biophotonics, 2024, 17
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Advances in organic nano-architectures based on NIR-II small-molecule fluorophores for biomedical imaging and therapy

Hui Bian, Dandan Ma, Yi Nan, Myung Hwa Kim, Sehoon Kim, Xiaoqiang Chen, Xiaojun Peng and Juyoung Yoon

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Supramolecular photothermal agents mediated by black hole hosts

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NIR-II light in clinical oncology: opportunities and challenges

Zeyu Zhang, Yang Du, Xiaojing Shi, Kun Wang, Qiaojun Qu, Qian Liang, Xiaopeng Ma, Kunshan He, Chongwei Chi, Jianqiang Tang, Bo Liu, Jiafu Ji, Jun Wang, Jiahong Dong, Zhenhua Hu and Jie Tian

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Regulated cell death mechanisms in mitochondria-targeted phototherapy

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Journal of Controlled Release, 2025, 382, 113720
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NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors

Ruizhen Jia, Han Xu, Chenlu Wang, Lichao Su, Jinpeng Jing, Shuyu Xu, Yu Zhou, Wenjing Sun, Jibin Song, Xiaoyuan Chen and Hongmin Chen

J Nanobiotechnol, 2021, 19
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Mitochondria‐Targeting Small‐Molecule NIR‐II Fluorescent Probes for Imaging and Treatment of Tumor

Mingxun Li, Yibin Wu, Chunfeng He, Xinxin Li, Ji Tao, Chunrong Qu, Wen‐Hua Chen and Zhen Cheng

Advanced Therapeutics, 2023, 6
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Acidogenesis‐Propelled Coordination Transition in Light‐Triggered Fe‐Polyphenol Polymer for Reactive Oxygen Species‐Augmented Antitumor Therapy

Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang and Lu An

Advanced Science, 2025, 12
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Development of Mitochondria-Targeted Small-Molecule Dyes for Myocardial PET and Fluorescence Bimodal Imaging

Lingling Zheng, Zhiming Wang, Xiaoqing Zhang, Yujing Zhou, Aiyan Ji, Hongyue Lou, Xingdang Liu, Hao Chen and Zhen Cheng

J. Med. Chem., 2022, 65, 497
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Near-infrared II chalcogenonium salt chromophores: Recent advances in imaging, biosensing, and therapeutic applications

Yanni Wang, Bingtao Ren, Xiujin Chang, Jong Seung Kim, Weidong Pan, Xiaodong Zeng, Yuling Xiao and Xuechuan Hong

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NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy

Yeneng Dai, Zhiquan Sun, Honghai Zhao, Dashan Qi, Xiangyu Li, Diya Gao, Meixing Li, Quli Fan, Qingming Shen and Wei Huang

Biomaterials, 2021, 275, 120935
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Subcellular targeting strategies: Chemical structure-based design concepts for bioimaging and theranostics

Qihang Ding, Zhiyun Zhang, Mingle Li, Jing-Hui Zhu, Wenpei Fu, Mengrong He, Ying Bai, Zewei Zhang, Shiying Li, Lin Wang, Cheng Deng, Xuechuan Hong, Yuling Xiao and Jong Seung Kim

Cell Biomaterials, 2025, 1, 100001
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Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy

Jiake Gao, Hongfei Jiang, Pengwei Chen, Renshuai Zhang and Ning Liu

Bioorganic Chemistry, 2023, 136, 106554
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The Application of Nanoparticle‐Based Imaging and Phototherapy for Female Reproductive Organs Diseases

Lihua Luo, Huanli Zhou, Sijie Wang, Mei Pang, Junlei Zhang, Yilong Hu and Jian You

Small, 2023
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Anti-Inflammatory Salidroside Delivery from Chitin Hydrogels for NIR-II Image-Guided Therapy of Atopic Dermatitis

Shengnan He, Fang Xie, Wuyue Su, Haibin Luo, Deliang Chen, Jie Cai and Xuechuan Hong

JFB, 2023, 14, 150
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2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

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Bioactive Materials, 2022, 14, 76
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Novel diketopyrrolopyrrole NIR-II fluorophores and DDR inhibitors for in vivo chemo-photodynamic therapy of osteosarcoma

Xiaoding Cheng, Chong Zhang, Kun Shen, Huifan Liu, Caihong Bai, Qihang Ding, Mengting Guan, Junzhu Wu, Zhiquan Tian, Deliang Chen, Lin Cai, Xuechuan Hong and Yuling Xiao

Chemical Engineering Journal, 2022, 446, 136929
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Organic small molecule-based photothermal agents for cancer therapy: Design strategies from single-molecule optimization to synergistic enhancement

Zhonglong Ding, Yinhui Gu, Cheng Zheng, Yueqing Gu, Jing Yang, Dahong Li, Yanni Xu and Peng Wang

Coordination Chemistry Reviews, 2022, 464, 214564
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A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via Optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT/NF‐κB/NLRP3 pathways

Junjie Chen, Longqi Chen, Zunpan She, Fang Zeng and Shuizhu Wu

Aggregate, 2024, 5
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Novel Dibenzofulvene‐Based NIR‐II Emission Phototheranostic Agent with an 82.6% Photothermal Conversion Efficiency for Photothermal Therapy

Yan‐Zhao Liu, Xiao‐Yun Ran, Ding‐Heng Zhou, Hong Zhang, Yu‐Jin Chen, Ji‐Xuan Xu, Shan‐Yong Chen, Qing‐Quan Kong, Xiao‐Qi Yu and Kun Li

Adv Funct Materials, 2024, 34
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Self-assembled NIR-II Fluorophores with Ultralong Blood Circulation for Cancer Imaging and Image-guided Surgery

Yang Li, Jianfeng Gao, Shuping Wang, Mingxia Du, Xiaowen Hou, Tian Tian, Xue Qiao, Zhiquan Tian, Peter J. Stang, Shijun Li, Xuechuan Hong and Yuling Xiao

J. Med. Chem., 2022, 65, 2078
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Organic single molecule based nano-platform for NIR-II imaging and chemo-photothermal synergistic treatment of tumor

Tonghang Chang, Qing Qiu, Aiyan Ji, Chunrong Qu, Hao Chen and Zhen Cheng

Biomaterials, 2022, 287, 121670
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BOIMPY-Based NIR-II Fluorophore with High Brightness and Long Absorption beyond 1000 nm for In Vivo Bioimaging: Synergistic Steric Regulation Strategy

Senyao Liu, Weijia Xu, Xiaoxin Li, Dai-Wen Pang and Hu Xiong

ACS Nano, 2022, 16, 17424
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Sequential enzyme-activated macrotheranostic probe for selective tumor mitochondria targeting

Di Ma, Qingyu Zong, Yuchen Du, Fangzhou Yu, Xuan Xiao, Rong Sun, Yuan Guo, Xinhua Wei and Youyong Yuan

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Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy

Long He, Yi Li, Chonghua Zhang, Xingxing Zhang, Benhua Wang, Tianbing Ren and Lin Yuan

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The pyroptosis-related gene signature predicts prognosis and reveals characterization of the tumor immune microenvironment in acute myeloid leukemia

Tao Zhou, Kai Qian, Yun-Yun Li, Wen-Ke Cai, Sun-Jun Yin, Ping Wang and Gong-Hao He

Front. Pharmacol., 2022, 13
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Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Xiangdan Meng, Xuejiao Pang, Kai Zhang, Chenchen Gong, Junyan Yang, Haifeng Dong and Xueji Zhang

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Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, Wanxia Gong, Yuncong Yuan, Xiaofei Miao, Huili Ma, Xuechuan Hong, Wenbo Hu and Yuling Xiao

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Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging

Yishen Liu, Yuzhen Yuzhen, Tian Tian, Wumei Wang, Jinxia Nong, Xue Qiao, Fuchun Xu, Jianfeng Gao and Xuechuan Hong

Chinese Chemical Letters, 2021, 32, 3061
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A mitochondria-targeted molecular phototheranostic platform for NIR-II imaging-guided synergistic photothermal/photodynamic/immune therapy

Sha Yang, Gui-long Wu, Na Li, Minghui Wang, Peixian Wu, Yuxuan He, Wei Zhou, Hao Xiao, Xiaofeng Tan, Li Tang and Qinglai Yang

J Nanobiotechnol, 2022, 20
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NIR‐II Organic Nanotheranostics for Precision Oncotherapy

Hanming Dai, Xiaorui Wang, Jinjun Shao, Wenjun Wang, Xiaozhou Mou and Xiaochen Dong

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Recent progress of rare earth doped hydroxyapatite nanoparticles: Luminescence properties, synthesis and biomedical applications

Mengqin Gu, Wei Li, Li Jiang and Xiyu Li

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Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy

Yang Li, Jianfeng Gao, Shuping Wang, Shijun Li, Xiaowen Hou, Yanna Pan, Jialu Gao, Xue Qiao, Zhiquan Tian, Deliang Chen, Hai Deng, Zixin Deng, Xuechuan Hong and Yuling Xiao

Journal of Controlled Release, 2022, 342, 157
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Ultra‐Bright Near‐Infrared Sulfonate‐Indolizine Cyanine‐ and Squaraine‐Albumin Chaperones: Record Quantum Yields and Applications

William E. Meador, Karina Kapusta, Iyanuoluwani Owolabi, Shane A. Autry, Julia Saloni, Wojciech Kolodziejczyk, Nathan I. Hammer, Alex S. Flynt, Glake A. Hill and Jared H. Delcamp

ChemPhotoChem, 2022, 6
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Water-Soluble Donor–Acceptor–Donor-Based Fluorophore for High-Resolution NIR-II Fluorescence Imaging Applications

Kun He, Shangyu Chen, Yan Chen, Jiewei Li, Pengfei Sun, Xiaomei Lu, Quli Fan and Wei Huang

ACS Appl. Polym. Mater., 2021, 3, 3238
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Lysosomal activable Vorinostat carrier-prodrug self-assembling with BPQDs enables photothermal oncotherapy to reverse tumor thermotolerance and metastasis

Yingjie Yu, Bingkai Wang, Miao Sun, Yunchang Zhang, Lei Hou, Sizhen Wang, Tianheng Chen, Feng Yang and Zhiqiang Ma

International Journal of Pharmaceutics, 2022, 617, 121580
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Platelet Membrane Coated Cu9S8‐SNAP for Targeting NIR‐II Mild Photothermal Enhanced Chemodynamic/Gas Therapy of Triple‐Negative Breast Cancer

Danping Wu, Xiaoyi Chen, Shijie Yao, Yichen He, Gongning Chen, Xiaojuan Hu, Yang Chen, Zhenye Lv, Jing Yu, Ketao Jin, Yu Cai and Xiaozhou Mou

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NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications

Chonglu Li, Xiaofang Guan, Xian Zhang, Di Zhou, Subin Son, Yunjie Xu, Mengtian Deng, Zhenzhong Guo, Yao Sun and Jong Seung Kim

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Highly Twisted Conformation Thiopyrylium Photosensitizers for In Vivo Near Infrared‐II Imaging and Rapid Inactivation of Coronavirus

Yishen Liu, Meijia Gu, Qihang Ding, Zhiyun Zhang, Wanxia Gong, Yuncong Yuan, Xiaofei Miao, Huili Ma, Xuechuan Hong, Wenbo Hu and Yuling Xiao

Angew Chem Int Ed, 2023, 62
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Rigidity Bridging Flexibility to Harmonize Three Excited‐State Deactivation Pathways for NIR‐II‐Fluorescent‐Imaging‐Guided Phototherapy

Weijing Huang, Huocheng Yang, Zongxing Hu, Yifan Fan, Xiaofang Guan, Wenqi Feng, Zhihong Liu and Yao Sun

Adv Healthcare Materials, 2021, 10
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Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Xin Chen, Jieyan Li, Shubham Roy, Zia Ullah, Jingsi Gu, Haiyan Huang, Chen Yu, Xuejin Wang, Han Wang, Yinghe Zhang and Bing Guo

Adv Healthcare Materials, 2024, 13
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Second near-infrared (NIR-II) imaging: a novel diagnostic technique for brain diseases

Na Xie, Ya Hou, Shaohui Wang, Xiaopeng Ai, Jinrong Bai, Xianrong Lai, Yi Zhang, Xianli Meng and Xiaobo Wang

Reviews in the Neurosciences, 2022, 33, 467
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A near-infrared IIb fluorophore for in vivo imaging and image-guided therapy of ischemic stroke

Xue Qiao, Yang Li, Wumei Wang, Yuling Xiao, Tian Tian, Xiaobo Wang, Haibin Luo, Deliang Chen, Xianli Meng, Xiaodong Zeng and Xuechuan Hong

Dyes and Pigments, 2023, 212, 111123
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Novel NIR-II fluorescent probes for biliary atresia imaging

Xiaodong Zeng, Yuqin Liao, Xue Qiao, Ke Liang, Qiusi Luo, Mingbo Deng, Yishen Liu, Weijing Zhang, Xuechuan Hong and Yuling Xiao

Acta Pharmaceutica Sinica B, 2023, 13, 4578
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Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Yuling Xu, Chonglu Li, Shuai Lu, Zhizheng Wang, Shuang Liu, Xiujun Yu, Xiaopeng Li and Yao Sun

Nat Commun, 2022, 13
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A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy

Yishen Liu, Qianqian Li, Meijia Gu, Disheng Lu, Xiaoxing Xiong, Zhiyun Zhang, Yanna Pan, Yuqin Liao, Qihang Ding, Wanxia Gong, Dean Shuailin Chen, Mengting Guan, Junzhu Wu, Zhiquan Tian, Hai Deng, Lijuan Gu, Xuechuan Hong and Yuling Xiao

J. Med. Chem., 2022, 65, 2225
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Aggregation‐Induced Emission (AIE) Nanoparticles‐Assisted NIR‐II Fluorescence Imaging‐Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)

Xiaoxiao Fan, Qiming Xia, Yiyin Zhang, Yirun Li, Zhe Feng, Jing Zhou, Ji Qi, Ben Zhong Tang, Jun Qian and Hui Lin

Adv Healthcare Materials, 2021, 10
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Advanced second near-infrared fluorophores for bioapplications

Qian Bai, Qingchao Yang, Yihan Liu, Ao Li, Xue-Bo Yin and Shuqi Wu

Coordination Chemistry Reviews, 2026, 547, 217146
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Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye

Songtao Cai, Liuying Wu, Yuan Li, Soham Samanta, Jinying Wang, Bing Liu, Feihu Wu, Kaitao Lai, Yingchao Liu, Junle Qu and Zhigang Yang

Chinese Chemical Letters, 2024, 35, 108599
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Bioimaging with Upconversion Nanoparticles

Evan M. Mettenbrink, Wen Yang and Stefan Wilhelm

Advanced Photonics Research, 2022, 3
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Novel HER2-Targeted Peptide for NIR-II Imaging of Tumor

Rui Cao, Renda Li, Hui Shi, Hongguang Liu and Zhen Cheng

Mol. Pharmaceutics, 2023, 20, 1394
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Mitochondria- and nucleus-targeted fluorescent probe for chemometrics-enhanced detection of cysteine

Zhang-Feng Tang, Min Zhang, Feng-Rui Yang, Yao Chen, Tong Wang, Zeng-Ping Chen and Ru-Qin Yu

Talanta, 2025, 291, 127870
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Tracking tumor heterogeneity and progression with near‐infrared II fluorophores

Qi Xin, Huizhen Ma, Hao Wang and Xiao‐Dong Zhang

Exploration, 2023, 3
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High‐Efficiency Organic Semiconducting Small Molecule for Deep‐Tissue Phototheranostics: Single 1064 nm Laser Triggered NIR‐IIb Fluorescence Imaging Guided Type‐I Photodynamic/Photothermal Combination Therapy

Qi Wang, Jiawei Liu, Linqiang Yang, Ze Tao, Jianfeng Feng, Sheng Li, Xiaoyuan Wang, Liang Gao, Weihua Tang and Quli Fan

Adv Funct Materials, 2025, 35
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