Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

Li Liao, Yan Tang, Bo Li, Jing Tang, Hong Xu, Ke Zhao and Xiaochun Zhang

Biomedicine & Pharmacotherapy, 2023, 161, 114489
DOI: 10.1016/j.biopha.2023.114489

Yiqi Huoxue Recipe Delayed Intervertebral Disc Degeneration by Activating Autophagy

Feng Dai, Pengfei Yu, Zhenhan Yu, Hong Jiang, Zhijia Ma and Jintao Liu

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.705747

Lactic acid promotes nucleus pulposus cell senescence and corresponding intervertebral disc degeneration via interacting with Akt

Yuyao Zhang, Libangxi Liu, Yuhan Qi, Jinhui Lou, Yuxuan Chen, Chao Liu, Haiyin Li, Xian Chang, Zhilei Hu, Yueyang Li, Yang Zhang, Chencheng Feng, Yue Zhou, Yu Zhai and Changqing Li

Cell. Mol. Life Sci., 2024, 81
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Establishment of intervertebral disc degeneration models; A review of the currently used models

Najah Elmounedi and Hassib Keskes

Journal of Orthopaedics, 2024, 56, 50
DOI: 10.1016/j.jor.2024.05.020

Identification of chondrocyte subpopulations in osteoarthritis using single-cell sequencing analysis

Han Gao, Jiawei Di, Mingyu Yin, Tianwei He, Depeng Wu, Zihao Chen, Shangfu Li, Lei He and Limin Rong

Gene, 2023, 852, 147063
DOI: 10.1016/j.gene.2022.147063

Maslinic acid alleviates intervertebral disc degeneration by inhibiting the PI3K/AKT and NF-κB signaling pathways

Yichen Que, Chipiu Wong, Jincheng Qiu, Wenjie Gao, Youxi Lin, Hang Zhou, Bo Gao, Pengfei Li, Zhihuai Deng, Huihong Shi, Wenjun Hu, Song Liu, Yan Peng, Peiqiang Su, Caixia Xu, Anjing Liang, Xianjian Qiu and Dongsheng Huang

ABBS, 2024
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NF-κB signaling pathway in osteosarcoma: from signaling networks to targeted therapy

Juandi Xue, Xiao-ran Yang and Li Wang

Front. Oncol., 2025, 15
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Metabolomics-based screening and chemically identifying abundant stachydrine as quality characteristic of rare Leucosceptrum canum Smith honey

Sha Yan, Xuan Wang, Hongmu Zhao, Huanxian Lu, Wenli Tian, Liming Wu and Xiaofeng Xue

Journal of Food Composition and Analysis, 2022, 114, 104759
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Melatonin mitigates matrix stiffness-induced intervertebral disk degeneration by inhibiting reactive oxygen species and melatonin receptors mediated PI3K/AKT/NF-κB pathway

Zhi-hui Liang, Jia Song, Wen-ji Shangguan, Qiu-qi Zhang, Jiang Shao and Yue-hui Zhang

American Journal of Physiology-Cell Physiology, 2024, 327, C1236
DOI: 10.1152/ajpcell.00630.2023

IL‐17 in intervertebral disc degeneration: Mechanistic insights and therapeutic implications

Jing‐Hua Tan, Ze‐Peng Li, Lu‐Lu Liu, Hao Liu and Jing‐Bo Xue

Cell Biology International, 2022, 46, 535
DOI: 10.1002/cbin.11767

Pharmacological Insights and Therapeutic Applications of Leonurus in Neurological Disorders

Yuting Wang, Xiaxue Wu, Ruofei Wu, Xiaona Sun, Yue Kang and Yue Yu

JIR, 2025, Volume 18, 11437
DOI: 10.2147/JIR.S527517

Dried and Fermented Powders of Edible Algae (Neopyropia yezoensis) Attenuate Hepatic Steatosis in Obese Mice

Koji Nagao, Nao Inoue, Keisuke Tsuge, Akira Oikawa, Tomoko Kayashima and Teruyoshi Yanagita

Molecules, 2022, 27, 2640
DOI: 10.3390/molecules27092640

Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF‐κB Signaling Pathways

Zhiheng Liao, Deying Su, Hengyu Liu, Caixia Xu, Jinna Wu, Yuyu Chen, Weimin Guo, Shun Zhang, Zhuling Li, Xiaona Ke, Tingting Wang, Taifeng Zhou, Peiqiang Su and Xinfeng Li

Oxidative Medicine and Cellular Longevity, 2022, 2022
DOI: 10.1155/2022/8672969

Stachydrine Protects Against Cyclophosphamide‐Induced Premature Ovarian Insufficiency in Wistar Rats by Inhibiting Oxidative Stress and Apoptosis via the Activation of the Nrf2/HO‐1 Signalling Pathway

Cong Feng, Yue Jiang, Yuehui Zhang, Yu Liu and Lihong Zhang

Clin Exp Pharma Physio, 2025, 52
DOI: 10.1111/1440-1681.70052

Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway

Xi Zhu, Yingbiao Wu, Xiaogang Zhang, Wei Gu and Zhongping Ning

J Cardiothorac Surg, 2023, 18
DOI: 10.1186/s13019-023-02363-6

Arctigenin inhibits apoptosis, extracellular matrix degradation, and inflammation in human nucleus pulposus cells by up‐regulating miR‐483‐3p

Zhe Ji, Rui Guo, Zhigang Ma and Hongwei Li

Clinical Laboratory Analysis, 2022, 36
DOI: 10.1002/jcla.24508

Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1‐RAGE/TLR4‐NF‐κB/AKT pathway

Zhihui Hu, Mian Xiao, Hengxing Cai, Wei Li, Wei Fang and Xing Long