A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions

Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán and Gilles Gasser

Chem. Sci., 2023, 14, 7170
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G-quadruplex-driven molecular disassembly and type I-to-type II photophysical conversion of a heavy-atom-free photosensitizer for site-specific oxidative damage

Karolina Saczuk, Maria V. Cottini, Marta Dudek, Leszek M. Mazur, Dario Puchán Sánchez, Lucía López-Pacios, Ahmad Kassem, Katarzyna Matczyszyn, Juan J. Nogueira, Cyrille Monnereau, Lara Martínez-Fernández, Jan Jamroskovic, Clément Cabanetos and Marco Deiana

Nanoscale Horiz., 2025, 10, 1660
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Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Guang-Xi Xu, Eunice Chiu-Lam Mak and Kenneth Kam-Wing Lo

Inorg. Chem. Front., 2021, 8, 4553
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Cyclometalated complexes: promising metallodrugs in the battle against cancer

Andrés Amaya-Flórez, Jordi R.-Galindo, Elkin Sanchez-Yocue, Adrian Ruiz-Martinez, Juan S. Serrano-García, Adriana Romo-Pérez, Patricia Cano-Sanchez, Viviana Reyes-Marquez, Ronan Le Lagadec and David Morales-Morales

RSC Med. Chem., 2025
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Metal–coumarin derivatives as promising photosensitizers: unlocking their cancer phototherapy potential

Gloria Vigueras, Eduardo Izquierdo-García, Elena de la Torre-Rubio, Diego Abad-Montero, Maria Dolores Santana, Vicente Marchán and José Ruiz

Inorg. Chem. Front., 2025, 12, 4355
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Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth inCaenorhabditis elegans

Enrique Ortega, Francisco J. Ballester, Alba Hernández-García, Samanta Hernández-García, M. Alejandra Guerrero-Rubio, Delia Bautista, M. Dolores Santana, Fernando Gandía-Herrero and José Ruiz

Inorg. Chem. Front., 2021, 8, 141
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Exploring the potential of ruthenium(ii)–phosphine–mercapto complexes as new anticancer agents

Marcos V. Palmeira-Mello, Analu R. Costa, Leticia P. de Oliveira, Olivier Blacque, Gilles Gasser and Alzir A. Batista

Dalton Trans., 2024, 53, 10947
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A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

Gloria Vigueras, Lenka Markova, Vojtech Novohradsky, Alicia Marco, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, José Ruiz and Viktor Brabec

Inorg. Chem. Front., 2021, 8, 4696
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Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)–COUPY conjugates

Enrique Ortega-Forte, Anna Rovira, Pezhman Ashoo, Eduardo Izquierdo-García, Cormac Hally, Diego Abad-Montero, Mireia Jordà-Redondo, Gloria Vigueras, Alba Deyà, José Luis Hernández, Jorge Galino, Manel Bosch, Marta E. Alberto, Antonio Francés-Monerris, Santi Nonell, José Ruiz and Vicente Marchán

Inorg. Chem. Front., 2025, 12, 3367
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New cyclometalated Ru(ii) polypyridyl photosensitizers trigger oncosis in cancer cells by inducing damage to cellular membranes

Jakub Cervinka, Alba Hernández-García, Delia Bautista, Lenka Markova, Hana Kostrhunova, Jaroslav Malina, Jana Kasparkova, M. Dolores Santana, Viktor Brabec and José Ruiz

Inorg. Chem. Front., 2024, 11, 3855
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Combination of light and Ru(II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

Luca Conti, Eleonora Macedi, Claudia Giorgi, Barbara Valtancoli and Vieri Fusi

Coordination Chemistry Reviews, 2022, 469, 214656
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Steric hindrance, ligand ejection and associated photocytotoxic properties of ruthenium(II) polypyridyl complexes

Piedad Herrera-Ramírez, Sarah Alina Berger, Dana Josa, David Aguilà, Ana B. Caballero, Pere Fontova, Vanessa Soto-Cerrato, Manuel Martínez and Patrick Gamez

J Biol Inorg Chem, 2023, 28, 403
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Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy

Johannes Karges, Hui Chao and Gilles Gasser

J Biol Inorg Chem, 2020, 25, 1035
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Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková

Inorg. Chem., 2023, 62, 6474
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Cytotoxic Imidazolyl-Mesalazine Ester-Based Ru(II) Complexes Reduce Expression of Stemness Genes and Induce Differentiation of Oral Squamous Cell Carcinoma

Pragya Kumari, Subhashis Ghosh, Sourav Acharya, Paromita Mitra, Souryadip Roy, Shilpendu Ghosh, Moumita Maji, Sandeep Singh and Arindam Mukherjee

J. Med. Chem., 2023, 66, 14061
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Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells

Andrés Restrepo-Acevedo, María Isabel Murillo, Christophe Orvain, Chloé Thibaudeau, Sevda Recberlik, Lucas Verget, Virginia Gómez Vidales, Christian Gaiddon, Georg Mellitzer and Ronan Le Lagadec

Inorg. Chem., 2025, 64, 9684
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COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents

Enrique Ortega-Forte, Anna Rovira, Albert Gandioso, Joaquín Bonelli, Manel Bosch, José Ruiz and Vicente Marchán

J. Med. Chem., 2021, 64, 17209
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Targeting translation: a promising strategy for anticancer metallodrugs

Enrique Ortega, Gloria Vigueras, Francisco José Ballester and José Ruiz

Coordination Chemistry Reviews, 2021, 446, 214129
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Inhibition of NF-κB-Mediated Proinflammatory Transcription by Ru(II) Complexes of Anti-Angiogenic Ligands in Triple-Negative Breast Cancer

Ayan Chakraborty, Shilpendu Ghosh, Manas Pratim Chakraborty, Sujato Mukherjee, Shantanu Saha Roy, Rahul Das, Moulinath Acharya and Arindam Mukherjee

J. Med. Chem., 2024, 67, 5902
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Target based chemotherapeutic advancement of ruthenium complexes

Pragti, Bidyut Kumar Kundu and Suman Mukhopadhyay

Coordination Chemistry Reviews, 2021, 448, 214169
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A Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent

Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Jorge Follana-Berná, Pezhman Ashoo, Diego Abad-Montero, Neus Isidro, Marta López-Corrales, Adrián Hernández, Javier Ortiz, Eduardo Izquierdo-García, Manel Bosch, Josep Rocas, Ángela Sastre-Santos, José Ruiz and Vicente Marchán

ACS Appl. Mater. Interfaces, 2024, 16, 38916
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A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy†

Enrique Ortega, Cristina Pérez-Arnaiz, Venancio Rodríguez, Christoph Janiak, Natalia Busto, Begoña García and José Ruiz

European Journal of Medicinal Chemistry, 2021, 222, 113600
DOI: 10.1016/j.ejmech.2021.113600

A Novel Near‐IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates

Marta Martínez‐Alonso, Albert Gandioso, Chloé Thibaudeau, Xue Qin, Philippe Arnoux, Nurikamal Demeubayeva, Vincent Guérineau, Céline Frochot, Alain C. Jung, Christian Gaiddon and Gilles Gasser

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300203