Recent developments in the chemical biology of amyloid-β oligomer targeting

Yalin Wang, Jiefang Chen, Furong Gao, Ming Hu and Xiaohui Wang

Org. Biomol. Chem., 2023, 21, 4540
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Nanomaterial synthesis, an enabler of amyloidosis inhibition against human diseases

Nicholas Andrikopoulos, Yuhuan Li, Luca Cecchetto, Aparna Nandakumar, Tatiana Da Ros, Thomas P. Davis, Kelly Velonia and Pu Chun Ke

Nanoscale, 2020, 12, 14422
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Bifunctional nanodisc platforms for studies on self-assembly and amyloid fibrillation

Bikash R. Sahoo, Takahiro Watanabe-Nakayama, Saba Suladze, G. M. Anantharamaiah, Bernd Reif and Ayyalusamy Ramamoorthy

Chem. Commun., 2025
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Sizes of amyloid-β oligomers predicted using atomic force microscopy and two-point crosslinked dimers as standards

Chikara Harada, Atsuya Matsui, Yumi Irie, Ayumi Uchino, Ayaka Chikugo, Kotaro Fujii, Katsuma Hosoi, Akio Nakanishi, Yusuke Kageyama, Nobuyasu Naruse, Chihiro Tsukano, Kazuhiro Irie and Yutaka Mera

Chem. Commun., 2025, 61, 9123
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In vitroandin vivomodels for anti-amyloidosis nanomedicines

Aleksandr Kakinen, Ibrahim Javed, Thomas P. Davis and Pu Chun Ke

Nanoscale Horiz., 2021, 6, 95
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Quantification of protein aggregation rates and quenching effects of amylin–inhibitor complexes

Suparna Khatun, Anurag Singh, Debabrata Mandal, Amreesh Chandra and Amar Nath Gupta

Phys. Chem. Chem. Phys., 2019, 21, 20083
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High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease

Bikash R. Sahoo, Sarah J. Cox and Ayyalusamy Ramamoorthy

Chem. Commun., 2020, 56, 4627
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Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers

Han-Wen Chang, Ho-I. Ma, Yi-Shan Wu, Ming-Che Lee, Eric Chung-Yueh Yuan, Shing-Jong Huang, Yu-Sheng Cheng, Meng-Hsin Wu, Ling-Hsien Tu and Jerry Chun Chung Chan

Chem. Sci., 2022, 13, 8526
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Growing tool-kit of photosensitizers for clinical and non-clinical applications

Suman Das, Manisha Tiwari, Devanjan Mondal, Bikash Ranjan Sahoo and Dhermendra K. Tiwari

J. Mater. Chem. B, 2020, 8, 10897
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A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation

Bikash R. Sahoo, Takuya Genjo, Takahiro W. Nakayama, Andrea K. Stoddard, Toshio Ando, Kazuma Yasuhara, Carol A. Fierke and Ayyalusamy Ramamoorthy

Chem. Sci., 2019, 10, 3976
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Lipid nanodiscs spontaneously formed by an amphiphilic polymethacrylate derivative as an efficient nanocarrier for molecular delivery to intact cells

Jinyu Hao, Mika Ishihara, Gwénaël Rapenne and Kazuma Yasuhara

RSC Adv., 2024, 14, 6127
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Nanomaterials in Alzheimer’s disease treatment: a comprehensive review

Maryam Faiyaz, Mohd. Azhardin Ganayee, Salman Akhtar, Saravanan Krishnan, Bableen Flora, Deeksha Dogra, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Kavindra Kumar Kesari and Piyush Kumar Gupta

Front. Biosci. (Landmark Ed), 2021, 26
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Creation of supramolecular biomembrane by the bottom-up self-assembly: Where material science meets biophysics

Kazuma Yasuhara and Kenichi Morigaki

BIOPHYSICS, 2022, 19, n/a
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Exploring interactions between lipids and amyloid-forming proteins: A review on applying fluorescence and NMR techniques

Ziwei Chang, Jing Deng, Weijing Zhao and Jun Yang

Chemistry and Physics of Lipids, 2021, 236, 105062
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Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers

Bikash R. Sahoo, Christopher L. Souders, Takahiro Watanabe-Nakayama, Zhou Deng, Hunter Linton, Saba Suladze, Magdalena I. Ivanova, Bernd Reif, Toshio Ando, Christopher J. Martyniuk and Ayyalusamy Ramamoorthy

Journal of Molecular Biology, 2022, 434, 167385
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Time-Dependent Lipid Dynamics, Organization and Peptide-Lipid Interaction in Phospholipid Bilayers with Incorporated β-Amyloid Oligomers

Wei Qiang, Katelynne E. Doherty, Lukas M. Klees and Yuto Tobin-Miyaji

J. Phys. Chem. Lett., 2020, 11, 8329
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Fibrillation mechanism of glucagon in the presence of phospholipid bilayers as revealed by 13C solid-state NMR spectroscopy

Izumi Yamane, Ayano Momose, Hideki Fujita, Eri Yoshimoto, Akie Kikuchi-Kinoshita, Izuru Kawamura and Akira Naito

Chemistry and Physics of Lipids, 2019, 219, 36
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Influence of Lipid Compositions in the Events of Retinal Schiff Base of Bacteriorhodopsin Embedded in Covalently Circularized Nanodiscs: Thermal Isomerization, Photoisomerization, and Deprotonation

Hsin-Yu Huang, Ming-Lun Syue, I-Chia Chen, Tsyr-Yan Yu and Li-Kang Chu

J. Phys. Chem. B, 2019, 123, 9123
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Molecular insights into the primary nucleation of polymorphic amyloid β dimers in DOPC lipid bilayer membrane

Olga Press‐Sandler and Yifat Miller

Protein Science, 2022, 31
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Preventing the amyloid-beta peptides accumulation on the cell membrane by applying GHz electric fields: A molecular dynamic simulation

N. Salehi, A. Lohrasebi and A.K. Bordbar

Journal of Molecular Graphics and Modelling, 2023, 123, 108516
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Membrane Proteins in Nanodiscs: Methods and Applications

Jiaxu Guo, Qinghan Hou, Yulin Tan, Ruoheng Fu, Xuanwei Huang and Chan Cao

ChemMedChem, 2025, 20
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Inhibitory Activity of Insulin on Aβ Aggregation Is Restricted Due to Binding Selectivity and Specificity to Polymorphic Aβ States

Michal Baram and Yifat Miller

ACS Chem. Neurosci., 2020, 11, 445
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1,7,9,10‐Tetrasubstituted PMIs Accessible through Decarboxylative Bromination: Synthesis, Characterization, Photophysical Studies, and Hydrogen Evolution Catalysis

Daniel Costabel, Artem Skabeev, Afshin Nabiyan, Yusen Luo, Johannes B. Max, Ashwene Rajagopal, Daniel Kowalczyk, Benjamin Dietzek, Maria Wächtler, Helmar Görls, Dirk Ziegenbalg, Yulian Zagranyarski, Carsten Streb, Felix H. Schacher and Kalina Peneva

Chemistry A European J, 2021, 27, 4081
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Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution

Bikash R. Sahoo, Takuya Genjo, Kanhu C. Moharana and Ayyalusamy Ramamoorthy

J. Phys. Chem. B, 2019, 123, 4562
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An optimistic approach to nanotechnology in Alzheimer's disease management: An overview

Varsha Tiwari, Abhishek Tiwari, Ajay Sharma, Manish Kumar, Deepak Kaushik and Suresh Sagadevan

Journal of Drug Delivery Science and Technology, 2023, 86, 104722
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Molecular Targets Underlying the Neuroprotective Effects of Boswellic Acid: A Systematic Review

Faezeh Khaafi and Behjat Javadi

MRMC, 2023, 23, 1912
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The human islet amyloid polypeptide in protein misfolding disorders: Mechanisms of aggregation and interaction with biomembranes

Adam El Saghir, Gianluca Farrugia and Neville Vassallo

Chemistry and Physics of Lipids, 2021, 234, 105010
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Preparation of Allyl Alcohol Oligomers Using Dipicolinate Oxovanadium(IV) Coordination Compound

Kacper Pobłocki, Dagmara Jacewicz, Juliusz Walczak, Barbara Gawdzik, Karol Kramkowski, Joanna Drzeżdżon and Paweł Kowalczyk

Materials, 2022, 15, 695
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NMR-based site-resolved profiling of β-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril

Yiling Xiao, Isamu Matsuda, Masafumi Inoue, Tomoya Sasahara, Minako Hoshi and Yoshitaka Ishii

Journal of Biological Chemistry, 2020, 295, 458
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Functionalized Mesoporous Silicas Direct Structural Polymorphism of Amyloid-β Fibrils

Michael J. Lucas, Henry S. Pan, Eric J. Verbeke, Lauren J. Webb, David W. Taylor and Benjamin K. Keitz

Langmuir, 2020, 36, 7345
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Solid-State NMR Study to Probe the Effects of Divalent Metal Ions (Ca2+ and Mg2+) on the Magnetic Alignment of Polymer-Based Lipid Nanodiscs

Thirupathi Ravula, Xiaofeng Dai and Ayyalusamy Ramamoorthy

Langmuir, 2021, 37, 7780
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The monomers, oligomers, and fibrils of amyloid-β inhibit the activity of mitoBKCa channels by a membrane-mediated mechanism

Yevheniia Kravenska, Hanna Nieznanska, Krzysztof Nieznanski, Elena Lukyanetz, Adam Szewczyk and Piotr Koprowski

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2020, 1862, 183337
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Procyanidine resists the fibril formation of human islet amyloid polypeptide

Jufei Xu, Ting Zheng, Xiangyi Huang, Yanan Wang, Guowei Yin and Weihong Du

International Journal of Biological Macromolecules, 2021, 183, 1067
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The application of multifunctional nanomaterials in Alzheimer’s disease: A potential theranostics strategy

Yilan Xu, Manna Zhao, Dongming Zhou, Tingting Zheng and Heng Zhang

Biomedicine & Pharmacotherapy, 2021, 137, 111360
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Effect of packing density of lipid vesicles on the Aβ42 fibril polymorphism

Chae Eun Heo, Chae Ri Park and Hugh I. Kim

Chemistry and Physics of Lipids, 2021, 236, 105073
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SERF, a family of tiny highly conserved, highly charged proteins with enigmatic functions

Bikash R. Sahoo and James C. A. Bardwell

The FEBS Journal, 2023, 290, 4150
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The Membrane Axis of Alzheimer's Nanomedicine

Yuhuan Li, Huayuan Tang, Nicholas Andrikopoulos, Ibrahim Javed, Luca Cecchetto, Aparna Nandakumar, Aleksandr Kakinen, Thomas P. Davis, Feng Ding and Pu Chun Ke

Advanced NanoBiomed Research, 2021, 1
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New lipid membrane technologies for reconstitution, analysis, and utilization of ‘living’ membrane proteins

Kazuma Yasuhara and Kenichi Morigaki

BIOPHYSICS, 2020, 17, 125
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Aβ42 oligomers can seed the fibrillization of Aβ40 peptides

Yi‐Shan Wu, Shing‐Jong Huang, Meng‐Hsin Wu, Ling‐Hsien Tu, Ming‐Che Lee and Jerry Chun Chung Chan

J Chinese Chemical Soc, 2022, 69, 1318
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The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins

Carmelo Tempra, Carmelo La Rosa and Fabio Lolicato

Chemistry and Physics of Lipids, 2021, 236, 105061
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Molecular insights into the phase transition of lysozyme into amyloid nanostructures: Implications of therapeutic strategies in diverse pathological conditions

Sindhujit Roy, Venkat Ramanan Srinivasan, Subash Arunagiri, Nishant Mishra, Anubhuti Bhatia, Kiran P. Shejale, Kailash Prasad Prajapati, Karunakar Kar and Bibin Gnanadhason Anand

Advances in Colloid and Interface Science, 2024, 331, 103205
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Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3

Youjia Zhang, Liang Ge, Li Xu, Yongrui Liu, Jiarong Wang, Chongxu Liu, Hongxin Zhao, Lei Xing, Junfeng Wang and Bo Wu

IJMS, 2023, 24, 1125
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Structure Analysis of Amyloid Aggregates at Lipid Bilayers by Supercritical Angle Raman Microscopy

Valentin Dubois, Diana Serrano, Xiaotian Zhang and Stefan Seeger

Anal. Chem., 2020, 92, 4963
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

Michele F. Sciacca, Fabio Lolicato, Carmelo Tempra, Federica Scollo, Bikash R. Sahoo, Matthew D. Watson, Sara García-Viñuales, Danilo Milardi, Antonio Raudino, Jennifer C. Lee, Ayyalusamy Ramamoorthy and Carmelo La Rosa

ACS Chem. Neurosci., 2020, 11, 4336
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Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Bikash R. Sahoo, Pritam Kumar Panda, Wenguang Liang, Wei-Jen Tang, Rajeev Ahuja and Ayyalusamy Ramamoorthy

Journal of Molecular Biology, 2021, 433, 166993
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Probing the interactions between amyloidogenic proteins and bio-membranes

Liang Ma, Xi Li, Robert B. Petersen, Anlin Peng and Kun Huang

Biophysical Chemistry, 2023, 296, 106984
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Acetylation of Aβ40 Alters Aggregation in the Presence and Absence of Lipid Membranes

Albert W. Pilkington, Jane Schupp, Morgan Nyman, Stephen J. Valentine, David M. Smith and Justin Legleiter

ACS Chem. Neurosci., 2020, 11, 146
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Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane

Young-Ho Lee, Yuxi Lin, Sarah J. Cox, Misaki Kinoshita, Bikash R. Sahoo, Magdalena Ivanova and Ayyalusamy Ramamoorthy

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019, 1867, 529
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Resistance of nepetin and its analogs on the fibril formation of human islet amyloid polypeptide

Jufei Xu, Ting Zheng, Cong Zhao, Xiangyi Huang and Weihong Du

International Journal of Biological Macromolecules, 2021, 166, 435
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Ultrasmall Molybdenum Disulfide Quantum Dots Cage Alzheimer’s Amyloid Beta to Restore Membrane Fluidity

Yuhuan Li, Huayuan Tang, Houjuan Zhu, Aleksandr Kakinen, Di Wang, Nicholas Andrikopoulos, Yunxiang Sun, Aparna Nandakumar, Eunbi Kwak, Thomas P. Davis, David Tai Leong, Feng Ding and Pu Chun Ke

ACS Appl. Mater. Interfaces, 2021, 13, 29936
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Polymer Nanodiscs and Their Bioanalytical Potential

Michelle D. Farrelly, Lisandra L. Martin and San H. Thang

Chemistry A European J, 2021, 27, 12922
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Exploring the binding kinetics and behaviors of self-aggregated beta-amyloid oligomers to phase-separated lipid rafts with or without ganglioside-clusters

Thuong Pham and Kwan H. Cheng

Biophysical Chemistry, 2022, 290, 106874
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17O Solid-State NMR Spectroscopy of Lipid Membranes

Riqiang Fu and Ayyalusamy Ramamoorthy

J. Phys. Chem. B, 2024, 128, 3527
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Multisite interactions of prions with membranes and native nanodiscs

Michael Overduin, Holger Wille and David Westaway

Chemistry and Physics of Lipids, 2021, 236, 105063
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A novel polymer micelle as a targeted drug delivery system for 10-hydroxycamptothecin with high drug-loading properties and anti-tumor efficacy

Yuyan Guo, Tao Gao, Fang Fang, Shuang Sun, Dayu Yang, Yongji Li and Shaowa Lv

Biophysical Chemistry, 2021, 279, 106679
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Self‐Assembly of Rod‐Coil Bottlebrush Copolymers into Degradable Nanodiscs with a UV‐Triggered Self‐Immolation Process

Haoxiang Zeng, Xiaoli Liang, Derrick A. Roberts, Elizabeth R. Gillies and Markus Müllner

Angewandte Chemie, 2024, 136
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High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways

Takahiro Watanabe-Nakayama, Bikash R. Sahoo, Ayyalusamy Ramamoorthy and Kenjiro Ono

IJMS, 2020, 21, 4287
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Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers

Bikash Ranjan Sahoo, Michael E. Bekier, Zichen Liu, Vojc Kocman, Andrea K. Stoddard, G.M. Anantharamaiah, James Nowick, Carol A. Fierke, Yanzhuang Wang and Ayyalusamy Ramamoorthy

Journal of Molecular Biology, 2020, 432, 1020
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A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer’s disease related Aβ(1-42) peptide

Pablo Zambrano, Malgorzata Jemiola-Rzeminska, Diego Muñoz-Torrero, Mario Suwalsky and Kazimierz Strzalka

Biophysical Chemistry, 2023, 300, 107061
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A new preparation method of covalent annular nanodiscs based on MTGase

Yingkui Dong, Ming Li, Li Kang, Wanxue Wang, Zehua Li, Yizhuo Wang, Ziwei Wu, Chenchen Zhu, Lei Zhu, Xinwei Zheng, Dongming Qian, Han Dai, Bo Wu, Hongxin Zhao and Junfeng Wang

Archives of Biochemistry and Biophysics, 2024, 756, 109997
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The interplay between lipid and Aβ amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities

Sara García-Viñuales, Michele F.M. Sciacca, Valeria Lanza, Anna Maria Santoro, Giulia Grasso, Grazia R. Tundo, Diego Sbardella, Massimiliano Coletta, Giuseppe Grasso, Carmelo La Rosa and Danilo Milardi

Chemistry and Physics of Lipids, 2021, 236, 105072
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Particulate systems for improving therapeutic efficacy of pharmaceuticals against central nervous system-related diseases

Yung-Chih Kuo and Rajendiran Rajesh

Journal of the Taiwan Institute of Chemical Engineers, 2020, 114, 12
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Self‐Assembly of Rod‐Coil Bottlebrush Copolymers into Degradable Nanodiscs with a UV‐Triggered Self‐Immolation Process

Haoxiang Zeng, Xiaoli Liang, Derrick A. Roberts, Elizabeth R. Gillies and Markus Müllner

Angew Chem Int Ed, 2024, 63
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Flavones in pomelo peel resist fibril formation of human islet amyloid polypeptide

Cuiyun Gao, Zhiruo Wan, Yan Liu, Yuting Meng, Xu Chen, Xiaohan Tang, Lingyu Hang and Hailong Yuan

Chinese Herbal Medicines, 2025, 17, 166
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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxing Chen, Brianna Hnath, Birgit Strodel, Rakez Kayed, Sylvain Lesné, Guanghong Wei, Fabio Sterpone, Andrew J. Doig and Philippe Derreumaux

Chem. Rev., 2021, 121, 2545
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