Modular design of nanobody–drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent

Hai Huang, Tiantian Wu, Hongdong Shi, Yun Wu, Hongyi Yang, Kai Zhong, Yucai Wang and Yangzhong Liu

Chem. Commun., 2019, 55, 5175
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Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics

Syeda Warisul Fatima, Khalid Imtiyaz, Mohammad M. Alam Rizvi and Sunil K. Khare

RSC Adv., 2021, 11, 34613
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Active regulation of protein coronas for enhancing the in vivo biodistribution and metabolism of nanoparticles

Duo Jin, Manman Liu, Yajie Zhang, Wenxin Yu, Jiaji Yu, Ying Luo, Junjie Cheng and Yangzhong Liu

Inorg. Chem. Front., 2024, 11, 5741
DOI: 10.1039/D4QI01000K

Clustered nanobody–drug conjugates for targeted cancer therapy

Tiantian Wu, Manman Liu, Hai Huang, Yaping Sheng, Haihua Xiao and Yangzhong Liu

Chem. Commun., 2020, 56, 9344
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An Affibody-Cytotoxin Conjugate-Based Nanoagent for EGFR Targeting and Precise Therapy of Epidermal Squamous Cell Carcinoma

Xiaoyuan Yang, Xuelin Xia, Qingrong Li, Mengqiao Zhao, Wenhui Gao, Xiao-Xia Xia, Wei Huang and Deyue Yan

ACS Appl. Nano Mater., 2025, 8, 2826
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Light‐triggered dePEGylation with decreasing the diameter of hydroxyapatite nanocarriers for enhanced cellular uptake and tumor penetration

Xiaojing Li, Dongmei Xi, Zhen Zhang, Saran Long, Pengzhong Chen, Jianjun Du, Wen Sun, Jiangli Fan and Xiaojun Peng

Nano Select, 2021, 2, 1954
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Nanobody—A versatile tool for cancer diagnosis and therapeutics

Manman Liu, Li Li, Duo Jin and Yangzhong Liu

WIREs Nanomed Nanobiotechnol, 2021, 13
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Generation and Application of Fluorescent Anti-Human β2-Microglobulin VHHs via Amino Modification

Chundong Huang, Da Li, Jun Ren, Fangling Ji and Lingyun Jia

Molecules, 2019, 24, 2600
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Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy

Shuyang Sun, Ziqiang Ding, Xiaomei Yang, Xinyue Zhao, Minlong Zhao, Li Gao, Qu Chen, Shenxia Xie, Aiqun Liu, Shihua Yin, Zhiping Xu and Xiaoling Lu

IJN, 2021, Volume 16, 2337
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Paper Title “Hu7CG2: A Novel Humanized Anti-Epidermal Growth Factor Receptor (EGFR) Biparatopic Nanobody”

Jafar Sharifi, Mohammad Reza Khirehgesh, Bahman Akbari, Bijan Soleymani and Kamran Mansouri

Mol Biotechnol, 2021, 63, 525
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Transglutaminase in Foods and Biotechnology

Katja Vasić, Željko Knez and Maja Leitgeb

IJMS, 2023, 24, 12402
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Targeted nanobody complex enhanced photodynamic therapy for lung cancer by overcoming tumor microenvironment

Qing Zhang, Lian Wu, Shaozheng Liu, Qingjie Chen, Lingpeng Zeng, Xuezhong Chen and Qing Zhang

Cancer Cell Int, 2020, 20
DOI: 10.1186/s12935-020-01613-0

Radioiodinated Nanobody immunoPET probe for in vivo detection of CD147 in pan-cancer

Xiaokun Ma, Teli Liu, Rui Guo, Wenyuan Zhou, Yuan Yao, Dan Wen, Jinping Tao, Jinyu Zhu, Feng Wang, Hua Zhu and Zhi Yang

Eur J Nucl Med Mol Imaging, 2025, 52, 1406
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Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics

Duo Jin, Manman Liu, Meng Zhang, Wenxin Yu, Jiaji Yu, Aizong Shen, Junjie Cheng and Yangzhong Liu

Advanced Drug Delivery Reviews, 2023, 192, 114648
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Lipoic Acid Ligase A‐Mediated Ligation: Mechanism, Applications, and Emerging Innovations in Bioconjugation

Shunsuke Yamazaki and Yutaka Matsuda

ChemistrySelect, 2023, 8
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Trends in nanobody technology in industrialization

Yuhao Wu

Discover Nano, 2025, 20
DOI: 10.1186/s11671-025-04200-2

Nanobodies as efficient drug-carriers: Progress and trends in chemotherapy

Sandeep Surendra Panikar, Nehla Banu, Jesse Haramati, Susana del Toro-Arreola, Annie Riera Leal and Pedro Salas

Journal of Controlled Release, 2021, 334, 389
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Application of Lanthanide-Doped Upconversion Nanoparticles for Cancer Treatment: A Review

Yu-Qi Liu, Li-Ying Qin, Hong-Jiao Li, Yi-Xi Wang, Rui Zhang, Jia-Min Shi, Jin-Hua Wu, Gen-Xi Dong and Ping Zhou

Nanomedicine (Lond.), 2021, 16, 2207
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Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

Jing Sun, Chunfang Wei, Yanan Liu, Wenjie Xie, Mengmeng Xu, Hui Zhou and Jie Liu

Biomaterials, 2019, 197, 417
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A hypothetical dual pH-sensitive nanoparticle strategy for enhanced drug delivery in pancreatic ductal adenocarcinoma

Ryan Sasse

Medical Hypotheses, 2025, 198, 111634
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Interaction standards for biophysics: anti-lysozyme nanobodies

Holly L. Birchenough, Hilda D. Ruiz Nivia and Thomas A. Jowitt

Eur Biophys J, 2021, 50, 333
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Delivery of cisplatin and resiquimod in nanomicelles for the chemoimmunotherapy of ovarian cancer

Wen Yin and Sumin Qian

Cancer Nano, 2022, 13
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Aptamers and nanobodies as alternatives to antibodies for ligand-targeted drug delivery in cancer

Dhruv Sanjanwala and Vandana Patravale

Drug Discovery Today, 2023, 28, 103550
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Native conjugation between proteins and [60]fullerene derivatives using SpyTag as a reactive handle

Guangzhong Yin, Jingjing Wei, Yu Shao, Wen-Hao Wu, Lianjie Xu and Wen-Bin Zhang

Chinese Chemical Letters, 2021, 32, 353
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Nanobody-based drug delivery systems for cancer therapy

Lin Liu, Bin Tu, Yao Sun, Lingling Liao, Xiaoling Lu, Ergang Liu and Yongzhuo Huang

Journal of Controlled Release, 2025, 381, 113562
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Molecular and functional insight into anti-EGFR nanobody: Theranostic implications for malignancies

Rajan K. Tripathy and Abhay H. Pande

Life Sciences, 2024, 345, 122593
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Enhancing Tumor Immunotherapy by Multivalent Anti‐PD‐L1 Nanobody Assembled via Ferritin Nanocage

Manman Liu, Duo Jin, Wenxin Yu, Jiaji Yu, Kaiming Cao, Junjie Cheng, Xiaohu Zheng, Andrew Wang and Yangzhong Liu

Advanced Science, 2024, 11
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SnoopLigase Enables Highly Efficient Generation of C–C-Linked Bispecific Nanobodies Targeting TNF-α and IL-17A

Jiewen Chen, Chundong Huang, Wei Zhao, Jun Ren, Fangling Ji and Lingyun Jia

Bioconjugate Chem., 2022, 33, 1446
DOI: 10.1021/acs.bioconjchem.2c00143

Mesoporous selenium nanoparticles for therapeutic goals: a review

Fateme Davarani Asl, Marziyeh Mousazadeh, Mostafa Azimzadeh and Mohammad Reza Ghaani

J Nanopart Res, 2022, 24
DOI: 10.1007/s11051-022-05572-7

Angiogenic biomolecules specific nanobodies application in cancer imaging and therapy; review and updates

Alireza Shoari, Mehdi Tahmasebi, Farnaz Khodabakhsh, Reza Ahangari Cohan, Akbar Oghalaie and Mahdi Behdani

International Immunopharmacology, 2022, 105, 108585
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CPPs to the Test: Effects on Binding, Uptake and Biodistribution of a Tumor Targeting Nanobody

Estel Collado Camps, Sanne A. M. van Lith, Cathelijne Frielink, Jordi Lankhof, Ingrid Dijkgraaf, Martin Gotthardt and Roland Brock

Pharmaceuticals, 2021, 14, 602
DOI: 10.3390/ph14070602

Nanobody‐Ferritin Conjugate for Targeted Photodynamic Therapy

Manman Liu, Yang Zhu, Tiantian Wu, Junjie Cheng and Yangzhong Liu

Chemistry A European J, 2020, 26, 7442
DOI: 10.1002/chem.202000075

Engineered Nanobodies Elicit Durable and Robust Bi‐Therapeutic Efficacy Toward Virus and Tumors

Bo Jia, Xinquan Gu, Siyu Shen, Yangyi Liu, Ming Li, Zheng Wei, Yao Sun, Chao Ma, Fan Wang, Juanjuan Su, Hongjie Zhang, Jingjing Li, Wei Wei and Kai Liu

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202407787

Integrated strategies for efficient production of Streptomyces mobaraensis transglutaminase in Komagataella phaffii

Sahibzada Muhammad Aqeel, Al-Adeeb Abdulqader, Guocheng Du and Song Liu

International Journal of Biological Macromolecules, 2024, 273, 133113
DOI: 10.1016/j.ijbiomac.2024.133113

EGFR and anti-EGFR nanobodies: review and update

Jafar Sharifi, Mohammad Reza Khirehgesh, Fatemeh Safari and Bahman Akbari

Journal of Drug Targeting, 2021, 29, 387
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Contemporary approaches to site-selective protein modification

Emily A. Hoyt, Pedro M. S. D. Cal, Bruno L. Oliveira and Gonçalo J. L. Bernardes

Nat Rev Chem, 2019, 3, 147
DOI: 10.1038/s41570-019-0079-1

Novel development strategies and challenges for anti-Her2 antibody-drug conjugates

Xinling Zhang, Andrew C Huang, Fahai Chen, Hu Chen, Lele Li, Nana Kong, Wenting Luo and Jianmin Fang

Antibody Therapeutics, 2022, 5, 18
DOI: 10.1093/abt/tbac001

Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery

Thinzar M. Lwin, Robert M. Hoffman and Michael Bouvet

Biomolecules, 2021, 11, 311
DOI: 10.3390/biom11020311

Conjugation of oxaliplatin with PEGylated-nanobody for enhancing tumor targeting and prolonging circulation

Li Li, Yang Zhu, Manman Liu, Duo Jin, Lei Zhang, Junjie Cheng and Yangzhong Liu

Journal of Inorganic Biochemistry, 2021, 223, 111553
DOI: 10.1016/j.jinorgbio.2021.111553