Issue 1, 2021

Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy

Abstract

Compared to traditional drug delivery systems, DNA nanostructure-based drug delivery systems have several advantages including programmable sequences, precise size and shape, high drug payloads, excellent biocompatibility and biodegradability. To date, a wide range of chemotherapeutic drug–DNA hybrid nanostructures have been developed for anti-tumor therapy. In this review, the constructions of various DNA nanostructures for anticancer drug delivery are firstly summarized. Next, the anticancer drug loading methods for DNA nanostructures are presented. Then, the recent applications of chemotherapeutic drug–DNA hybrid nanostructures for drug delivery are highlighted. In the end, the challenges and opportunities of the chemotherapeutic drug–DNA hybrid nanostructure-based delivery system are discussed. The designs of drug–DNA hybrid systems, including the constructions of nanostructures and the strategies for drug loading, largely influence the efficiency of drug delivery. Recent studies have focused on the development of novel drug–DNA hybrid systems to acquire more precise and efficient therapy for various diseases. A systematic review of the design strategies of chemotherapeutic drug–DNA hybrid nanostructures will benefit the innovation and development of the chemotherapeutic drug-based chemotherapy in clinics.

Graphical abstract: Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy

Article information

Article type
Review Article
Submitted
30 Ապր 2020
Accepted
18 Օգս 2020
First published
19 Օգս 2020

Mater. Horiz., 2021,8, 78-101

Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy

X. Huang, N. T. Blum, J. Lin, J. Shi, C. Zhang and P. Huang, Mater. Horiz., 2021, 8, 78 DOI: 10.1039/D0MH00715C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements