Issue 46, 2020

Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

Abstract

With the ever-present need for novel asymmetric methodologies in organic synthesis to allow chemists to access enantiopure compounds, so too is there a need for new chiral ligands and organocatalysts to affect these transformations. Due to the unique properties of ferrocene and its derivatives, ferrocenyl compounds are unsurprisingly considered privileged structures in asymmetric catalysis. The versatility of the ferrocene moiety gives rise to a vast range of diverse ligand and catalyst motifs which are successful in broad ranges of mechanistically distinct reactions. This review details recent advances in the application of ferrocenyl mono-, bi- and tridentate-ligands and ferrocene-derived organocatalysts in asymmetric catalysis. Given the necessity for the development of new approaches to expand the scope of ferrocenyl ligands and catalysts, this review also illustrates the development of elegant and novel methodologies for the synthesis of ferrocenyl compounds.

Graphical abstract: Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

Associated articles

Article information

Article type
Review Article
Submitted
19 Սպտ 2020
Accepted
24 Հկտ 2020
First published
26 Հկտ 2020

Org. Biomol. Chem., 2020,18, 9329-9370

Recent developments in the synthesis and applications of chiral ferrocene ligands and organocatalysts in asymmetric catalysis

L. Cunningham, A. Benson and P. J. Guiry, Org. Biomol. Chem., 2020, 18, 9329 DOI: 10.1039/D0OB01933J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements