Silver-mediated oxidative functionalization of alkylsilanes

Abstract

A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported. This strategy encompasses a range of valuable C–Si transformations, including the direct conversions of a C–Si bond to C–OCF₃, C–OBz, C–OCOCF₃, C–SCF₃, C–SCN, and C–N₃ bonds. Among them, trifluoromethoxylation of alkylsilanes is reported for the first time. In addition, mechanistic studies indicate that this reaction may proceed through a radical mechanism.