Issue 66, 2024

Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides

Abstract

We describe a palladium-catalyzed Suzuki-type cross-coupling reaction of 2-pyridyl carbamoyl fluorides with boronic acids, which provides entry to medicinally relevant pyridyl amides. Mechanistic studies, including the synthesis and reactivity of carbamoyl Pd–F complexes, reveal the importance of both the fluoride electrophile and nitrogen directing group for aiding reactivity.

Graphical abstract: Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides

Supplementary files

Article information

Article type
Communication
Submitted
19 Մյս 2024
Accepted
18 Հլս 2024
First published
19 Հլս 2024

Chem. Commun., 2024,60, 8700-8703

Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides

M. Jabbarpoor, J. LeBlanc, Z. Chen, D. Cadwallader and C. M. Le, Chem. Commun., 2024, 60, 8700 DOI: 10.1039/D4CC02431A

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