Introduction to the themed collection on ‘Induced-Proximity Pharmacology’

Ingo V. Hartung, Lindsey I. James and Lyn H. Jones

RSC Med. Chem., 2025,16, 2311-2313

From themed collection: Induced-Proximity Pharmacology

Abstract

Ingo Hartung, Lindsey James and Lyn Jones introduce the RSC Medicinal Chemistry themed collection on ‘Induced-Proximity Pharmacology’.

Contents list

RSC Med. Chem., 2024,15, 2577-2584

Introduction to the themed collection in honour of Professor Christian Leumann

Marcel Hollenstein and Eugen Stulz

RSC Med. Chem., 2024,15, 3636-3638

From themed collection: Nucleic Acid Chemistry: celebrating Christian Leumann’s retirement

Abstract

Marcel Hollenstein and Eugen Stulz introduce the cross-journal themed collection celebrating Christian Leumann’s retirement.

Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches

Julien Hazemann, Thierry Kimmerlin, Roland Lange, Aengus Mac Sweeney, Geoffroy Bourquin, Daniel Ritz and Paul Czodrowski

RSC Med. Chem., 2024,15, 2146-2159

From themed collection: Highlights from Industry

Abstract

A pragmatic approach to the discovery of new SARS-COV-2 Mpro inhibitors by combining generative chemistry and computational chemistry approaches.

Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity

Hakan Aslan, Gioele Renzi, Andrea Angeli, Ilaria D'Agostino, Roberto Ronca, Maria Luisa Massardi, Camilla Tavani, Simone Carradori, Marta Ferraroni, Paolo Governa, Fabrizio Manetti, Fabrizio Carta and Claudiu T. Supuran

RSC Med. Chem., 2024,15, 1929-1941

Abstract

One-step synthesis and a chemical similarity-based screening provide new tumor-associated carbonic anhydrase (CA) inhibitors for anticancer application.