This study reveals how metal coordination alters albumin binding, influencing bioavailability and guiding rational drug design strategies.
The cytotoxicity profiles of two Au(III) chelate enantiomers were established in NCI-60 screens. Together with their differential binding to HSA, the 1S,2S enantiomer exhibits a more active molecular biology profile than the 1R,2R enantiomer.
Four titanium(IV) derivatives were synthesized, and two characterized by SC-XRD. These complexes have been found to exhibit higher activity for DNA/BSA binding as well as high potency for cytotoxicity against the MCF-7 and HT-29 cancer cell lines.
Investigation of photophysical properties and interaction with human serum albumin protein of ten metal-free porphyrinoid–azulene based systems as photosensitizers for application in photodynamic therapy.
A Zn(II) complex and a Cu(II) azametallacoronate with (E)−2−((2−(quinazolin−4−yl)hydrazono)methyl)phenol were evaluated for the interaction with calf−thymus DNA, photocleavage of plasmid DNA, antioxidant activity and affinity for bovine albumin.