Recent advances in smart responsive hydrogel microspheres for tissue regeneration: preparation, characteristics and applications

Zijian Wu, Guang Shi, Luhao Li, Zhenzhou Piao, Junwu Wang, Renxin Chen, Zhuowen Hao, Zheyuan Zhang, Zouwei Li, Yilong Huang and Jingfeng Li

Mater. Horiz., 2025
DOI: 10.1039/D5MH01020A

Recent Advances in Injectable Stimuli-Responsive Hydrogels for Biomedical Applications

Hanieh Khonakdar, Morteza Ehsani, Ghasem Naderi, Fatemeh Shokrolahi and Hossein Ali Khonakdar

J Polym Environ, 2025, 33, 3512
DOI: 10.1007/s10924-025-03620-6

Therapeutic Hydrogels: Properties and Biomedical Applications

Songtao Dong, Soohwan An, Qimanguli Saiding, Qian Chen, Bin Liu, Na Kong, Wei Chen and Wei Tao

Chem. Rev., 2025, 125, 8835
DOI: 10.1021/acs.chemrev.5c00182

Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives

He Liu and Ya Shen

Int Endodontic J, 2025, 58, 674
DOI: 10.1111/iej.14208

Hydrogel‐Transformable Probiotic Powder for Targeted Eradication of Helicobacter pylori with Enhanced Gastric Mucosal Repair and Microbiota Preservation

Yongkang Lai, Hanchun Shen, Shige Wang, Yongliang Ouyang, Xinyuan Zhang, Bin Hu, Xiaoyi Zhang, Guisheng Li, Lizhi Xu and Jiulong Zhao

Advanced Science, 2025, 12
DOI: 10.1002/advs.202500478

Research on the application of biomaterial-based responsive hydrogels in the tumor microenvironment

Wanrong Yue, Xiaoyu Zhu, Ming Wu, Wenyue Qiang, Yixin Yang, Ziyun Zhang, Youwei Wang, Yuanyin Teng and Mi Zhou

PeerJ, 2025, 13, e19609
DOI: 10.7717/peerj.19609

Reactive Oxygen Species-Responsive Polymer Drug Delivery System Targeted Oxidative Stressed Colon Cells to Ameliorate Colitis

Wo-Qi Cai, Wanqi Liang, Dong Li, Wenli Dai, Zhishu Li, Xinlin Wei, Lizeng Cheng, Bo-Bo Zhang and Qiongqiong Yang

ACS Nano, 2025, 19, 17287
DOI: 10.1021/acsnano.4c14373

Cerium Dioxide Nanoparticles‐Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy

Li Chen, Jianye Yang, Zhengwei Cai, Yanran Huang, Qinyang Zhang, Chengqiang Zhou, Juan Wang, Wei Huang, Wenguo Cui and Ning Hu

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202405069

Advanced Responsive Hydrogels for Diabetic Wound Healing: Design Principles, Controlled Drug Delivery, Therapeutic Strategies, and Application Prospects

Jiyuan Du, Caihong Xian, Xiaodan Liang, Shirou Fan, Liying Wang and Jun Wu

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70019

Smart Materials and Devices for Enhanced Delivery of Extracellular Vesicles

Yang You, Mengrui Liu, Na Yan, Dashuai Zhu, Xiao Cheng, Yilan Hu, Yuan Li, Zhen Qin, Zhixin Zhu and Ke Cheng

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202501081

Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring

Xinghan He, Yongyi Wei and Ke Xu

Gels, 2025, 11, 647
DOI: 10.3390/gels11080647

Engineering encapsulated living bacteria for advanced healthcare management

Ming Teng, Xiaomin Luo, Jiang Chang, Chen Yang, Xiaomeng Zhang, Liuying Li, Xudan Liu, Ruizhi Zhi, Xu Guo and Xinhua Liu

Biotechnology Advances, 2025, 83, 108640
DOI: 10.1016/j.biotechadv.2025.108640

4D printed hydrogels for precision delivery of bioactive molecules in cancer

Uxia Gato-Diaz, Angel Concheiro, Carmen Alvarez-Lorenzo and Barbara Blanco-Fernandez

Expert Opinion on Drug Delivery, 2025, 1
DOI: 10.1080/17425247.2025.2539959

A New Paradigm for Precision Drug Delivery in Inflammatory Bowel Disease: Effective Transfer, Enhanced Retention, and Pathology‐Targeting Treatment via Biomaterials and Engineered Platforms

Ruoyi Gan, Enqi Ni, Guanyue Li and Wei Chen

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70022

Polypyrrole-Modified Triple-Responsive Hydrogel Dressing Based on Bacterial Cellulose and Quaternary Ammonium Chitosan and Its Synergistic Antibacterial Mechanism

Xinru Wang, Jie Zhang, Jinyu Shan, Dong Yang, Jie Yang, Guangming Tian, Yunzhi Dang and Jianhua Ma

ACS Appl. Mater. Interfaces, 2025, 17, 50417
DOI: 10.1021/acsami.5c12061

Smart hydrogels for postoperative adhesion prevention: Mechanisms, material innovations, and clinical potential

Dechao Guo, Yiying Zhao, Xinxing Sun, Yue Zheng and Biaotong Huang

International Journal of Biological Macromolecules, 2025, 322, 146564
DOI: 10.1016/j.ijbiomac.2025.146564

Application and progress of smart hydrogels in regulating oxidative stress and improving the immune microenvironment in osteoarthritis

Wenyu Wang, Junjie Jiang, Hongli Yu and Yong Sun

Chemical Engineering Journal, 2025, 522, 167273
DOI: 10.1016/j.cej.2025.167273

Glutathione depletion-based pH-responsive injectable hydrogels for synergistic treatment of colon tumor

Xinyuan Zhang, Yu Li, Yanhui Zhang, Shige Wang, Jiulong Zhao and Tianjiao Wang

International Journal of Biological Macromolecules, 2025, 297, 139557
DOI: 10.1016/j.ijbiomac.2025.139557

A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration

Siya Wang, Yu Zhai, Minghan Liu, Zhuo Cheng, Jiayi Zhang, Haifeng Zhang, Haibing Wang, Yan Hu, Changqing Li and Zhong Luo

Acta Biomaterialia, 2025, 203, 229
DOI: 10.1016/j.actbio.2025.07.033

Soft–hard active–passive embedded structures: a review of smart structures with design and modeling guidelines

Adrian Ehrenhofer and Thomas Wallmersperger

Smart Mater. Struct., 2025, 34, 033005
DOI: 10.1088/1361-665X/adbdb3

An engineering-reinforced extracellular vesicle–integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury

Jian Cao, Xunqi Zhang, Jing Guo, Jiahe Wu, Lingmin Lin, Xurong Lin, Jiafu Mu, Tianchen Huang, Manning Zhu, Lan Ma, Weihang Zhou, Xinchi Jiang, Xuhua Wang, Shiqing Feng, Zhen Gu and Jian-Qing Gao

Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.ads3398

Advanced 3PM strategies in traditional Chinese medicine gels for wound healing integrating 3D/4D printing, network pharmacology and multiomics technologies

Shengjian Ni, Wenyang Zhao, Karthikeyan Elumalai and Palanirajan Vijayaraj Kumar

EPMA Journal, 2025, 16, 621
DOI: 10.1007/s13167-025-00414-7

Bacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds

Ying Luo, Xiaoli Jia, Xiaozhuo Wu, Ling Diao, Yawei Zhao, Xing Liu, Yi Peng, Wen Zhong, Malcolm Xing and Guozhong Lyu

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-03056-5

Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine

Tiansheng Wang and Didier Astruc

Coordination Chemistry Reviews, 2025, 524, 216300
DOI: 10.1016/j.ccr.2024.216300

Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis

Wanjun Liang, Rui Yang, Lijing Qin, Tongjuan Liang and Wei Chen

Macromolecular Bioscience, 2025, 25
DOI: 10.1002/mabi.202500016

From Bench to Bedside: Hydrogel Platforms Bridging Anti‐Adhesion Barriers, Tissue Regeneration, and Personalized Postoperative Recovery

Ting Wang, Hanchao Zhou, Jiangchuan He, Yunhe Zheng, Jinpeng Wen, Yu Huang, Kailai Liu, Yuchen Zhang and Ke Wang

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70021

Smart multifunctional Cu2O@RuO2 nanozyme for angiogenesis and osteogenesis in periodontitis

Yuyang Li, Faheem Muhammad, Xiwen Chen, Deao Gu, Wen Li, Jiayi Tang, Mingyue Cheng, Jiang Du, Shuwei Qiao, Yu Deng, Qing Yu, Hui Wei and Leiying Miao

Nano Today, 2025, 61, 102624
DOI: 10.1016/j.nantod.2024.102624

Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis

Ziyi Xu, Yue Wang, Shuoshun Li, Yuanhong Li, Lili Chang, Yang Yao and Qiang Peng

Biomaterials Advances, 2025, 175, 214326
DOI: 10.1016/j.bioadv.2025.214326

Microenvironment‐Responsive Piezoelectric Nanofibers Antagonize Chemotherapy‐Induced Peripheral Neuropathy

Jing Xu, Zhenwei Yang, Xuemin Cao, Jibin Liu, Yubo Yang, Jing Qi, Zhaozheng Ren, Siyuan Yin, Yuhan Liu, Yujuan Zhu, Lin Chen and Feng Wang

Adv Funct Materials, 2025
DOI: 10.1002/adfm.202510274

Baicalein based nano-delivery system restores mitochondrial homeostasis through PPAR signaling pathway to promote wound healing in diabetes

Danlei Qin, Weiting Hu, Yanqin Guo, Rui Cheng, Fengxiang Hao and Bin Zhao

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03427-6