A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction

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Chem. Sci., 2023, 14, 10800
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Selection and evolution of disulfide-rich peptides via cellular protein quality control

Xiaoting Meng, Chaoying Xu, Shihui Fan, Meng Dong, Jie Zhuang, Zengping Duan, Yibing Zhao and Chuanliu Wu

Chem. Sci., 2023, 14, 3668
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Directing the oxidative folding of disulfide-rich peptides for enhanced engineering and applications

Xueting Cheng and Chuanliu Wu

Chem. Sci., 2025, 16, 19012
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TROP2-targeted NIR-II fluorescence imaging for visualizing surgical margins and metastatic sentinel lymph nodes in breast cancers

Kang-Liang Lou, Jing-Wen Bai, Hong-Tan Liu, Lin-Ling Lin, Cheng-Xi Li, Yi-Yang Gao, Sheng-Jie Lin, Yi-Fei Pei, Xiao-Long Wei, Yi-Xin Chen, Yi-Yin Tang, Hong-Yu Chen, Zhi-Yao Li, Rong Guo, Shi-Cong Tang, Chuan-Liu Wu and Guo-Jun Zhang

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Artificial Intelligence in Molecular Optimization: Current Paradigms and Future Frontiers

Xin Xia, Yajie Zhang, Xiangxiang Zeng, Xingyi Zhang, Chunhou Zheng and Yansen Su

IJMS, 2025, 26, 4878
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Specifically targeted antimicrobial cyclic peptide to staphylococcal protein A for the treatment of S. aureus infection

Xiao-Ling Lei, Yong Li, Xue-Ting Cheng, Jie Zhuang, Fang Zhang, Xiao-Ting Xie, Lin-Fang Tan, Jin-Xuan Fan, Yuan-Di Zhao, Chuan-Liu Wu and Kai Cheng

Chemical Engineering Journal, 2025, 512, 162243
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Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Simon Hansen, Yingnan Zhang, Sunhee Hwang, Ahmad Nabhan, Wanqing Li, Jakob Fuhrmann, Yvonne Kschonsak, Lijuan Zhou, Aaron H. Nile, Xinxin Gao, Robert Piskol, Felipe de Sousa e Melo, Frederic J. de Sauvage and Rami N. Hannoush

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Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs

Shuaimin Lu, Shihui Fan, Shuling Xiao, Jinjing Li, Shilong Zhang, Yapei Wu, Chuilian Kong, Jie Zhuang, Hongtan Liu, Yibing Zhao and Chuanliu Wu

J. Am. Chem. Soc., 2023, 145, 1964
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Exploring Phage Peptide Scaffolds: Tyrosinase-Mediated Cyclization for Selective Generation of Bioactive Cyclic Peptides

Li-Wen Bai, Peng Cheng, Ting Dan, Hua Xiang, Xiao-Qin Yang, Yi-Fei Chen, Shu-Sen Li, Zheng-Hui Li, Jin-Ming Gao and Xinxiang Lei

J. Am. Chem. Soc., 2025, 147, 35090
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Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition

Chuanliu Wu

Acc. Chem. Res., 2025, 58, 1620
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Directed Evolution of Multicyclic Peptides Using Yeast Display for Sensitive and Selective Fluorescent Analysis of CD28 on the Cell Surface

Chaoying Xu, Xiaoting Meng, Ping Chai, Hongtan Liu, Zengping Duan, Yu-Hsuan Tsai and Chuanliu Wu

Anal. Chem., 2025, 97, 4031
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Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable α-Helices for Recognition and Activation of G Protein-Coupled Receptors

Shihui Fan, Jie Li, Jie Zhuang, Qingtong Zhou, Yiting Mai, Bingni Lin, Ming-Wei Wang and Chuanliu Wu

J. Am. Chem. Soc., 2025, 147, 4821
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Multicyclic Peptides Targeting PD-L1 for Radiotheranostics: From Discovery to Clinical Proof-of-Concept

Xueting Cheng, Shuo Jiang, Xingtong Peng, Pan Yang, Siqi Zhang, Chaoying Xu, Xin Gao, Shihui Fan, Hongtan Liu, Jie Zhuang, Xueyao Chen, Naixin Liang, Bingni Lin, Qingshuang Lu, Meirong Chen, Yibei Xiao, Zhaohui Zhu, Rui Wang, Kuan Hu and Chuanliu Wu

J. Am. Chem. Soc., 2025, 147, 35638
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Disulfide-Directed Multicyclic Peptides for Chimeric Antigen Receptors Targeting Solid Tumors

Xiaoting Meng, Keke Fu, Yawei Liu, Yuan Liu, Joe Z. Zhang, Xi Kang, Chuanliu Wu and Yu-Hsuan Tsai

J. Am. Chem. Soc., 2026, 148, 400
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D‐Peptide and D‐Protein Technology: Recent Advances, Challenges, and Opportunities**

Alexander J. Lander, Yi Jin and Louis Y. P. Luk

ChemBioChem, 2023, 24
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Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery

Junjie Liu, Xiangnan Sun, Jie Zhuang, Ziyan Liu, Chaoying Xu, Dalei Wu and Chuanliu Wu

Sci. China Chem., 2025, 68, 1434
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Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders

Zengping Duan, Chuilian Kong, Shihui Fan and Chuanliu Wu

Nat Commun, 2024, 15
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CD28 and ICOS in immune regulation: Structural insights and therapeutic targeting

Saurabh Upadhyay, Baljit Kaur and Moustafa T. Gabr

Bioorganic & Medicinal Chemistry Letters, 2025, 127, 130310
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Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders

Hongtan Liu, Lulu Song, Xiaoting Meng, Jinjing Li, Shihui Fan, Huilei Dong, Xiaoran Wang, Maolin Li, Haipeng Yu, Yu-Hsuan Tsai, Yizhen Yin and Chuanliu Wu

J. Am. Chem. Soc., 2025, 147, 24870
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Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery

Alexander J. Lander, Yifu Kong, Yi Jin, Chuanliu Wu and Louis Y. P. Luk

ACS Bio Med Chem Au, 2024, 4, 68
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De Novo Discovery of Cysteine Frameworks for Developing Multicyclic Peptide Libraries for Ligand Discovery

Jinjing Li, Hongtan Liu, Shuling Xiao, Shihui Fan, Xueting Cheng and Chuanliu Wu

J. Am. Chem. Soc., 2023, 145, 28264
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Comparative Analysis of Deep Learning‐Based Algorithms for Peptide Structure Prediction

Clément Sauvestre, Jean‐François Zagury and Florent Langenfeld

Proteins, 2026, 94, 675
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