Toward target 2035: EUbOPEN - a public–private partnership to enable & unlock biology in the open

Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J. Brown, Alex N. Bullock, Alessio Ciulli, Ivan Dikic, Kristina Edfeldt, Aled M. Edwards, Jonathan M. Elkins, Henner F. Farin, Edward A. Fon, Matthias Gstaiger, Judith Günther, Anna-Lena Gustavsson, Sandra Häberle, Laura Isigkeit, Kilian V. M. Huber, Andras Kotschy, Oliver Krämer, Andrew R. Leach, Brian D. Marsden, Hisanori Matsui, Daniel Merk, Florian Montel, Monique P. C. Mulder, Susanne Müller, Dafydd R. Owen, Ewgenij Proschak, Sandra Röhm, Alexandra Stolz, Michael Sundström, Frank von Delft, Timothy M. Willson, Cheryl H. Arrowsmith and Stefan Knapp

RSC Med. Chem., 2025, 16, 457
DOI: 10.1039/D4MD00735B

Innovative, combinatorial and high-throughput approaches to degrader synthesis

Rebecca Stevens, James D. F. Thompson, Julie C. L. Fournier, Glenn A. Burley, David J. Battersby and Afjal H. Miah

Chem. Soc. Rev., 2024, 53, 4838
DOI: 10.1039/D3CS01127E

A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation

Pau Nadal Rodríguez, Frederick Hartung, Marina Pedrola, Seemon Coomar, Alejandro Diaz-Moreno, Anna M. Hätälä, Katharina M. Rolfes, Ismael Sánchez-Vera, Joan Gil, Elies Molins, Antonio Viayna, Alexander Hanzl, Nicolas H. Thomä, Thomas Haarmann-Stemmann, F. Javier Luque, Rodolfo Lavilla and Ouldouz Ghashghaei

ACS Cent. Sci., 2025, 11, 629
DOI: 10.1021/acscentsci.5c00194

Function and mechanism of lactylation in health and diseases: a comprehensive review

Yiren Yang, Longxin Deng, Hanzhong Zhang, Jiatao Hu, Jinxin Li, Linhui Wang and Xinxin Gan

International Journal of Surgery, 2025, 111, 5387
DOI: 10.1097/JS9.0000000000002623

Molecular glue-mediated targeted protein degradation: A novel strategy in small-molecule drug development

Xueqiang Tan, Zuyi Huang, Hairun Pei, Zongchao Jia and Jimin Zheng

iScience, 2024, 27, 110712
DOI: 10.1016/j.isci.2024.110712

Phosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes

Rajaiah Pergu, Vedagopuram Sreekanth, Praveen Kokkonda, Sophia Lai, Praveen K. Tiwari, Sameek Singh, Junya Kawai, Santanu Singha, Wenzhi Tian, Vikram Thimaradka, Surached Siriwongsup, Kien Tran and Amit Choudhary

J. Am. Chem. Soc., 2025, 147, 25316
DOI: 10.1021/jacs.5c04275

Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for Tumor-Immune Proximity Induction

Benjamin P. M. Lake and Anthony F. Rullo

ACS Cent. Sci., 2023, 9, 2064
DOI: 10.1021/acscentsci.3c01052

Discovery of Molecular Glue Degraders via Isogenic Morphological Profiling

Amanda Ng, Fabian Offensperger, Jose A. Cisneros, Natalie S. Scholes, Monika Malik, Ludovica Villanti, Andrea Rukavina, Evandro Ferrada, J. Thomas Hannich, Anna Koren, Stefan Kubicek, Giulio Superti-Furga and Georg E. Winter

ACS Chem. Biol., 2023, 18, 2464
DOI: 10.1021/acschembio.3c00598

A chemical magnet: Approaches to guide precise protein localization

Saurav Kumar and Behnam Nabet

Bioorganic & Medicinal Chemistry, 2024, 102, 117672
DOI: 10.1016/j.bmc.2024.117672

Characterizing the Cooperative Effect of PROTAC Systems with End-Point Binding Free Energy Calculation

Kexin Xu, Zhe Wang, Sutong Xiang, Rongfan Tang, Qirui Deng, Jingxuan Ge, Zhiliang Jiang, Kaimo Yang, Tingjun Hou and Huiyong Sun

J. Chem. Inf. Model., 2024, 64, 7666
DOI: 10.1021/acs.jcim.4c01227

The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders

Alessio Ciulli, Suzanne O'Connor, Chun‐Wa Chung, Ingo V. Hartung, Andrea Testa, Danette L. Daniels and Laura H. Heitman

ChemMedChem, 2023, 18
DOI: 10.1002/cmdc.202300464

Modulating Phosphorylation by Proximity-Inducing Modalities for Cancer Therapy

Qiuyue Zhang, Jia Yu, Qidong You and Lei Wang

J. Med. Chem., 2024, 67, 21695
DOI: 10.1021/acs.jmedchem.4c02624

The Transcription Machinery and the Driving Force of the Transcriptional Molecular Condensate: The Role of Phosphates

Raúl Riera Aroche, Esli C. Sánchez Moreno, Yveth M. Ortiz García, Andrea C. Machado Sulbarán, Lizbeth Riera Leal, Luis R. Olivas Román and Annie Riera Leal

CIMB, 2025, 47, 571
DOI: 10.3390/cimb47070571

Harnessing molecular proximity for antiviral innovations: advances in proximity-inducing modalities against viral infections

Linan Wu, Shujing Xu, Yang Zhou, Dazhou Shi, Mei Wang, Meehyein Kim and Peng Zhan

Sci. China Chem., 2025
DOI: 10.1007/s11426-025-2658-0

Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling

Nickolas J. Serniuck, Eden Kapcan, Duane Moogk, Allyson E. Moore, Benjamin P.M. Lake, Galina Denisova, Joanne A. Hammill, Jonathan L. Bramson and Anthony F. Rullo

Molecular Therapy: Oncology, 2024, 32, 200842
DOI: 10.1016/j.omton.2024.200842

Opportunities for Therapeutic Modulation of O-GlcNAc

Steven S. Cheng, Alison C. Mody and Christina M. Woo

Chem. Rev., 2024, 124, 12918
DOI: 10.1021/acs.chemrev.4c00417

From Concepts to Inhibitors: A Blueprint for Targeting Protein–Protein Interactions

Seong Ho Hong, Thu Nguyen, Joseph F. Ongkingco, Alex Nazzaro and Paramjit S. Arora

Chem. Rev., 2025, 125, 6819
DOI: 10.1021/acs.chemrev.5c00046

Expanding the horizons of targeted protein degradation: A non-small molecule perspective

Xiaowei Huang, Fengbo Wu, Jing Ye, Lian Wang, Xiaoyun Wang, Xiang Li and Gu He

Acta Pharmaceutica Sinica B, 2024, 14, 2402
DOI: 10.1016/j.apsb.2024.01.010

Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs

Georg E. Winter

ACS Chem. Biol., 2024, 19, 2089
DOI: 10.1021/acschembio.4c00191