Molecular recognition between bacterial phosphorothioate DNA and sulfur-binding domain (SBD): competition between the water cage and chalcogen-hydrophobic packet

Jiayi Li, Haibo Wan, Haoqing Zhang, Xiao-Lei Wang, Guang Liu, Geng Wu, Xinyi He, Zixin Deng and Yi-Lei Zhao

Phys. Chem. Chem. Phys., 2022, 24, 9176
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Metal ion complexes of nucleoside phosphorothioates reflecting the ambivalent properties of lead(ii)

Astrid Sigel, Bert P. Operschall, Roland K. O. Sigel and Helmut Sigel

New J. Chem., 2018, 42, 7551
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Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost

Pradeep S. Pallan, Terry P. Lybrand, Mark K. Schlegel, Joel M. Harp, Hartmut Jahns, Muthiah Manoharan and Martin Egli

Biochemistry, 2020, 59, 4627
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Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer–Thrombin Complex

Martin Egli and Terry P. Lybrand

J. Am. Chem. Soc., 2019, 141, 4445
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Synthesis of Nucleotides Bearing the 2′‐O‐Trifluoromethyl Group and Their Application in RNA Analogs Preparation

Xuan Chen, Long Xie, Chenglong Zhang, Shen Tian, Zeyu Tang, Ming Xiang, Weiwei Tian, Patrick Lu and Xianbin Yang

Current Protocols, 2024, 4
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Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts

Kazuhiko Yamasaki, Yukie Akutsu, Tomoko Yamasaki, Makoto Miyagishi and Tomomi Kubota

Nucleic Acids Research, 2020, 48, 4551
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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

Jörg Duschmalé, Adrian Schäublin, Erik Funder, Steffen Schmidt, Łukasz J. Kiełpiński, Helle Nymark, Klaus Jensen, Troels Koch, Martina Duschmalé, Erich Koller, Marianne Ravn Møller, Simone Schadt, Christophe Husser, Andreas Brink, Sabine Sewing, Tanja Minz, Jesper Wengel, Konrad Bleicher and Meiling Li

Molecular Therapy - Nucleic Acids, 2022, 29, 176
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One Way Traffic: Base‐to‐Backbone Hole Transfer in Nucleoside Phosphorodithioate

Renata Kaczmarek, Samuel Ward, Dipra Debnath, Taisiya Jacobs, Alexander D. Stark, Dariusz Korczyński, Anil Kumar, Michael D. Sevilla, Sergey A. Denisov, Viacheslav Shcherbakov, Pascal Pernot, Mehran Mostafavi, Roman Dembinski and Amitava Adhikary

Chemistry A European J, 2020, 26, 9495
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Aptamer–Protein Interactions: From Regulation to Biomolecular Detection

Cailing Ji, Junyuan Wei, Lei Zhang, Xinru Hou, Jie Tan, Quan Yuan and Weihong Tan

Chem. Rev., 2023, 123, 12471
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Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

Rafal Dolot, Curtis H Lam, Malgorzata Sierant, Qiang Zhao, Feng-Wu Liu, Barbara Nawrot, Martin Egli and Xianbin Yang

Nucleic Acids Research, 2018, 46, 4819
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A Convenient Method for the Synthesis of 2′‐O‐Cyanoethylated Nucleotides and Their Application in the Solid‐Phase Synthesis of Related RNA Analogs

Xuan Chen, Long Xie, Chenglong Zhang, Shen Tian, Zeyu Tang, Weiwei Tian, Patrick Lu and Xianbin Yang

Current Protocols, 2023, 3
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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

Malwina Hyjek-Składanowska, Timothy A. Vickers, Agnieszka Napiórkowska, Brooke A. Anderson, Michael Tanowitz, Stanley T. Crooke, Xue-hai Liang, Punit P. Seth and Marcin Nowotny

J. Am. Chem. Soc., 2020, 142, 7456
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Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines

Mohan Liu, Yusi Wang, Yibing Zhang, Die Hu, Lin Tang, Bailing Zhou and Li Yang

Sig Transduct Target Ther, 2025, 10
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