Issue 9, 2023

Construction of a desirable hyperbolic microfluidic chip for ultrasensitive determination of PCT based on chemiluminescence

Abstract

Since procalcitonin (PCT) is a specific inflammation indicator of severe bacterial inflammation and fungal infection, it is of great significance to construct a sensitive and rapid microfluidic chip to detect PCT in clinical application. The design of micromixers using a lab-on-a-chip (LOC) device is the premise to realizing the adequate mixing of analytical samples and reagents and is an important measure to improve the accuracy and efficiency of determination. In this research study, we investigate the mixing characteristics of hyperbolic micromixers and explore the effects of different hyperbolic curvatures, different Reynolds numbers (Re) and different channel widths on the mixing performance of the micromixers. Then, an optimal micromixer was integrated into a microfluidic chip to fabricate a desirable hyperbolic microfluidic chip (DHMC) for the sensitive determination of inflammation marker PCT with a limit of detection (LOD) as low as 0.17 ng mL−1via a chemiluminescence signal, which can be used as a promising real-time platform for early clinical diagnosis.

Graphical abstract: Construction of a desirable hyperbolic microfluidic chip for ultrasensitive determination of PCT based on chemiluminescence

Supplementary files

Article information

Article type
Paper
Submitted
27 okt. 2022
Accepted
26 jan. 2023
First published
26 jan. 2023

J. Mater. Chem. B, 2023,11, 1978-1986

Construction of a desirable hyperbolic microfluidic chip for ultrasensitive determination of PCT based on chemiluminescence

B. Yin, W. Yue, A. S. M. M. F. Sohan, X. Wan, T. Zhou, L. Shi, C. Qian and X. Lin, J. Mater. Chem. B, 2023, 11, 1978 DOI: 10.1039/D2TB02338E

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