From gut to brain: formulation and transporter-guided approaches to maximise rutin central nervous system delivery

Shaobo Zhou, Halimatu Hassan, Jin Guo, Yan Xu, Pengxia Zhang, Linhong Yuan, Tao Zhou and Ruoli Chen

Nutritional Neuroscience, 2026, 1
DOI: 10.1080/1028415X.2026.2617363

Cow placenta extract ameliorates d-galactose-induced liver damage by regulating BAX/CASP3 and p53/p21/p16 pathways

Liuhong Shen, Lei Fan, Hao Luo, Weiyao Li, Suizhong Cao and Shumin Yu

Journal of Ethnopharmacology, 2024, 323, 117685
DOI: 10.1016/j.jep.2023.117685

Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging

Ying Liu, Minglv Fang, Xiaohui Tu, Xueying Mo, Lu Zhang, Binrui Yang, Feijie Wang, Young-Bum Kim, Cheng Huang, Liang Chen and Shengjie Fan

Nutrients, 2024, 16, 3305
DOI: 10.3390/nu16193305

A study on the anti-senescent effects of flavones derived from Prinsepia utilis Royle seed residue

Junxi Liu, Liping Qu, Feifei Wang, Zaoju Mei, Xinlang Wu, Bo Wang, Haiyang Liu and Li He

Journal of Ethnopharmacology, 2024, 328, 118021
DOI: 10.1016/j.jep.2024.118021

The therapeutic potential of plant-derived flavonoids in neurological disorders through modulation of brain insulin signaling

Isabella Supardi Parida, Halida Rahmania and Kiyotaka Nakagawa

FSTR, 2025, 31, 75
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Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens

Mengke Yan, Xin Cong, Hui Wang, Kun Qin, Yuhui Tang, Xiao Xu, Dan Wang, Shuiyuan Cheng, Yulan Liu and Huiling Zhu

Poultry Science, 2025, 104, 104620
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Diosgenin alleviates D-galactose-induced oxidative stress in rats’ brain and liver targeting aging and apoptotic marker genes

Ali H. El-Far, Mona M. Elghaity, Shymaa A. Mohamed, Ahmed E. Noreldin, Yaser H. A. Elewa, Soad Khalil Al Jaouni and Abdelwahab A. Alsenosy

Front. Mol. Biosci., 2024, 11
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Exploring the mechanisms of cow placental peptides in delaying liver aging based on mitochondrial energy metabolism

Zeru Zhang, Yuxin Luo, Hanwen Zhang, Zhi Zeng, Weijian Zheng, Yuquan Zhao, Yixin Huang and Liuhong Shen

Journal of Ethnopharmacology, 2025, 345, 119593
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Macrophage iron dyshomeostasis promotes aging‐related renal fibrosis

Lingzhi Wu, Hongchun Lin, Shaomin Li, Yuebo Huang, Yuxiang Sun, Shuangshuang Shu, Ting Luo, Tiantian Liang, Weiyan Lai, Jialing Rao, Zhaoyong Hu and Hui Peng

Aging Cell, 2024, 23
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Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

Min Kim, Seung-Cheol Jee and Jung-Suk Sung

Antioxidants, 2024, 13, 180
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Rutin targets AKT to inhibit ferroptosis in ventilator‐induced lung injury

Shengsong Chen, Zhonghao Li, Yuhong Xiao, Zhaobin Zhou, Qingyuan Zhan and Lingling Yu

Phytotherapy Research, 2024, 38, 3401
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Protective Effect of a Highly Enriched Nacre-Derived Neutral Polysaccharide Fraction on D-Galactose-Induced Pancreatic Dysfunction

Heng Zhang and Yasushi Hasegawa

Molecules, 2025, 30, 3555
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The multiple mechanisms and therapeutic significance of rutin in metabolic dysfunction-associated fatty liver disease (MAFLD)

Qianzhuo Wang, Yingjuan Zhang, Ruiling Lu, Qingwen Zhao and Yue Gao

Fitoterapia, 2024, 178, 106178
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Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway

Xin Zhou, Zhibin Wang, Yuting Wang, Guofeng Xu, Min Luo, Mengwei Zhang and Yuying Li

Front. Pharmacol., 2025, 16
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Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles

Badriyah S. Alotaibi, Amany Abdel-Rahman Mohamed, Yasmina M. Abd-Elhakim, Ahmed E. Noreldin, Moustafa Elhamouly, Tarek Khamis, Ali H. El-Far, Manal E. Alosaimi, Naief Dahran, Leena S. Alqahtani, Mario Nicotra, Mohamed El-Gamal and Alessandro Di Cerbo

Front. Pharmacol., 2024, 15
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Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

Mona H. Hafez, Heba E. Elshafaei, Hanan A. Edres, Asmaa F. Khafaga, Ahmed E. Noreldin and Kariman A. Esmail

Tissue and Cell, 2026, 98, 103208
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Liposome-Encapsulated Rutin Attenuates Cisplatin-Induced Ototoxicity via Suppression of P53-Associated Oxidative Injury

Bo Liu, Yaqin Tu, Xiangrui Li, Wenting Yu, Wenqing Zou, Wei Tang, Shimin Zong, Songwei Tan and Hongjun Xiao

Biomater Res, 2026, 30
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Pulmonary damage induction upon Acrylic amide exposure via activating miRNA-223–3p and miRNA-325–3p inflammasome/pyroptosis and fibrosis signaling pathway: New mechanistic approaches of A green-synthesized extract

Amirah Albaqami, Manal E. Alosaimi, Ibrahim Jafri, Amany Abdel-Rahman Mohamed, Yasmina M. Abd El-Hakim, Tarek Khamis, Sara T. Elazab, Ahmed E. Noreldin, Moustafa Elhamouly, Ali H. El-Far, Areej A. Eskandrani, Badriyah S. Alotaibi, Hanim M.abdelnour and Ayman A. Saleh

Toxicology, 2024, 506, 153869
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Molecular mechanisms of neuroprotective effect of rutin

Zhang Chunmei and Wang Shuai

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1599167

Towards Better and More Valid Zebrafish Models of Alzheimer's Disease: A Scientific Tribute to Prof. Mikhail I. Aghajanov

Maria M. Kotova, Adam Michael Stewart, Artem Grigoryan, Sanobar Shariff, Foad Mirzaei, Burhan Kantawala, Karen Dilbaryan, Murilo S. de Abreu, David S. Galstryan, Jiahao Cui, Longen Yang, Konstantin B. Yenkoyan and Allan V. Kalueff

Journal of Neurochemistry, 2025, 169
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Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging

Li Luo, Tao Yan, Le Yang and Minggao Zhao

Computational and Structural Biotechnology Journal, 2024, 23, 2230
DOI: 10.1016/j.csbj.2024.05.036

Rutin Attenuates Oxidative Stress Responses and Hepatocyte Metabolomics in β-Hydroxybutyric Acid-Induced Hepatocyte Injury in Calves

Kun Yang, Haixia Zhao, Min Gao, Honglian Hu and Dabiao Li

IJMS, 2025, 26, 5878
DOI: 10.3390/ijms26125878

Investigating the role of Purkinje fibers and synaptic connectivity in balance regulation through comprehensive ultrastructural and immunohistochemical analysis of the donkey's (Equus asinus) cerebellum

Samar M. Ez Elarab, Mohamed A.M. Alsafy, Samir A.A. El‐Gendy, Neveen E.R. El‐Bakary, Ahmed Elsayed Noreldin and Ahmed M. Rashwan

J Exp Zool Pt A, 2024, 341, 293
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