Uptake and release of perfluoroalkyl carboxylic acids (PFCAs) from macro and microplastics

Philip J. Brahana, Ahmed Al Harraq, Luis E. Saab, Ruby Roberg, Kaillat T. Valsaraj and Bhuvnesh Bharti

Environ. Sci.: Processes Impacts, 2023, 25, 1519
DOI: 10.1039/D3EM00209H

Gestational PFAS concentrations in association with maternal depression and perceived stress during pregnancy and postpartum in the ECHO cohort

Susanna D. Mitro, Wei Yang, Assiamira Ferrara, Monique M. Hedderson, Max Aung, Himal Suthar, Radhika S. Raghunathan, Yeyi Zhu, Alicia K. Peterson, Morgan Reynolds, Kurunthachalam Kannan, Emily Oken, Margaret R. Karagas, Alison E. Hipwell, Thomas G. O'Connor, Courtney Carignan, Carrie V. Breton, Theresa M. Bastain, Catherine Karr, Kristen Lyall and Lyndsay A. Avalos

Environmental Research, 2025, 286, 122997
DOI: 10.1016/j.envres.2025.122997

Mobilization of Per- and Polyfluoroalkyl Substances (PFAS) in Soils: A Review

Charbel Abou-Khalil, Dibyendu Sarkar, Pamela Braykaa and Michel C. Boufadel

Curr Pollution Rep, 2022, 8, 422
DOI: 10.1007/s40726-022-00241-8

Interpretable Machine Learning on Metabolomics Data Reveals Biomarkers for Parkinson’s Disease

J. Diana Zhang, Chonghua Xue, Vijaya B. Kolachalama and William A. Donald

ACS Cent. Sci., 2023, 9, 1035
DOI: 10.1021/acscentsci.2c01468

PFAS removal from reverse osmosis and nanofiltration brine by granular activated carbon: Thermodynamic insights into salinity effects

Jiefei Cao, Siyuan Feng, Alireza Arhami Dolatabad, Yue Zhi, Baolin Deng, Caihong Liu, Xueyan Lyu, Charlotte S.Q. Christensen, Joseph J. Pignatello, Pan Ni, Shihong Lin, Zongsu Wei and Feng Xiao

Water Research, 2025, 282, 123758
DOI: 10.1016/j.watres.2025.123758

Impact of Redox Imbalance and Mitochondrial Dysfunction on Neurotoxicity Induced by Perfluorooctanoic Acid in Male Wistar Albino Rats (Rattus norvegicus)

Lavanya Hongal and M. David

J of Applied Toxicology, 2025
DOI: 10.1002/jat.70009

Recent Advances in Perfluorocarbon-Based Delivery Systems for Cancer Theranostics

Yueying Yang, Yunhu Liu and Yanyan Jiang

Mol. Pharmaceutics, 2023, 20, 3254
DOI: 10.1021/acs.molpharmaceut.3c00116

The impact of early life exposure to individual and combined PFAS on learning, memory, and bioaccumulation in C. elegans

Seth D. Currie, Yuqing Ji, Qingguo Huang, Jia-Sheng Wang and Lili Tang

Environmental Pollution, 2024, 363, 125257
DOI: 10.1016/j.envpol.2024.125257

Multiple-challenge regional industrial transitions: The example of chemical regions

Maximilian Benner

Environmental Innovation and Societal Transitions, 2025, 55, 100971
DOI: 10.1016/j.eist.2025.100971

Cognitive impairment and dementia by pollutant exposure: a review

Liehai Hu and Dongmei Li

Environ Chem Lett, 2025, 23, 1801
DOI: 10.1007/s10311-025-01870-3

The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science

Francesca Spyrakis and Tommaso A. Dragani

Toxics, 2023, 11, 721
DOI: 10.3390/toxics11090721

Associations of exposure to perfluoroalkyl substances with serum uric acid change and hyperuricemia among Chinese women: Results from a longitudinal study

Yue Feng, Ming Fu, Xin Guan, Chenming Wang, Hua Meng, Yuhan Zhou, Meian He and Huan Guo

Chemosphere, 2022, 308, 136438
DOI: 10.1016/j.chemosphere.2022.136438

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Himal Suthar, Tomás Manea, Dominic Pak, Megan Woodbury, Stephanie M. Eick, Amber Cathey, Deborah J. Watkins, Rita S. Strakovsky, Brad A. Ryva, Subramaniam Pennathur, Lixia Zeng, David Weller, June-Soo Park, Sabrina Smith, Erin DeMicco, Amy Padula, Rebecca C. Fry, Bhramar Mukherjee, Andrea Aguiar, Sarah Dee Geiger, Shukhan Ng, Gredia Huerta-Montanez, Carmen Vélez-Vega, Zaira Rosario, Jose F. Cordero, Emily Zimmerman, Tracey J. Woodruff, Rachel Morello-Frosch, Susan L. Schantz, John D. Meeker, Akram N. Alshawabkeh and Max T. Aung

Environ. Sci. Technol., 2024, 58, 8264
DOI: 10.1021/acs.est.4c00094

Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations

Karla M. Ríos-Bonilla, Diana S. Aga, Jungeun Lee, Maria König, Weiping Qin, Judith R. Cristobal, Gunes Ekin Atilla-Gokcumen and Beate I. Escher

Environ. Sci. Technol., 2024
DOI: 10.1021/acs.est.4c06017

Perfluoroalkyl and polyfluoroalkyl substances crossing the blood-joint barrier: Their occurrence and distribution in synovial fluid

Huiying Guo, Zifeng Wu, Guiwang Shen, Zhiyu Huang, Zhengang Zha, Xiaofei Zheng, Xiaojun Luo, Bixian Mai, Jinshao Ye and Jieruo Li

Journal of Hazardous Materials, 2025, 492, 138189
DOI: 10.1016/j.jhazmat.2025.138189

Prenatal exposure to PFAS and the association with neurobehavioral and social development during childhood

Trisha Saha, M. Corinaud J. Gbemavo, Linda Booij, Tye E. Arbuckle, Jillian Ashley-Martin, Mandy Fisher, Gina Muckle, Bruce Lanphear, Elizabeth Asztalos, Jean Séguin and Maryse F. Bouchard

International Journal of Hygiene and Environmental Health, 2025, 263, 114469
DOI: 10.1016/j.ijheh.2024.114469

Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity

Kelly E. Carstens, Theresa Freudenrich, Kathleen Wallace, Seline Choo, Amy Carpenter, Marci Smeltz, Matthew S. Clifton, W. Matthew Henderson, Ann M. Richard, Grace Patlewicz, Barbara A. Wetmore, Katie Paul Friedman and Timothy Shafer

Chem. Res. Toxicol., 2023, 36, 402
DOI: 10.1021/acs.chemrestox.2c00344

The sources and bioaccumulation of per- and polyfluoroalkyl substances in animal-derived foods and the potential risk of dietary intake

Yudong Xing, Yan Zhou, Xin Zhang, Xia Lin, Jiaoyang Li, Peng Liu, Hian Kee Lee and Zhenzhen Huang

Science of The Total Environment, 2023, 905, 167313
DOI: 10.1016/j.scitotenv.2023.167313

Per- and polyfluoroalkyl substances (PFAS) exposure in plasma and their blood–brain barrier transmission efficiency–A pilot study

Meng-Yi Xie, Zhi-Ying Lin, Xiang-Fei Sun, Jing-Jing Feng, Lei Mai, Chen-Chou Wu, Guang-Long Huang, Po Wang, Ya-Wei Liu, Liang-Ying Liu and Eddy Y. Zeng

Environment International, 2024, 187, 108719
DOI: 10.1016/j.envint.2024.108719

Per- and Polyfluoroalkyl Substances in Potential Drinking Water Sources Globally: Distributions, Monitoring Trends, and Risk Assessment

Yangyuan Zhou, Yu Chang, Dawei Zhang and Weiying Li

Water, 2025, 17, 3280
DOI: 10.3390/w17223280

First insight into the sex-dependent accumulation, tissue distribution and potential toxicities of 2-ethylhexyl diphenyl phosphate and its metabolites in adult zebrafish

Rongyan Yang, Yi Yang, Liping Yang, Hao Chen, Wenjue Zhong and Lingyan Zhu

Journal of Hazardous Materials, 2023, 452, 131299
DOI: 10.1016/j.jhazmat.2023.131299

Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Danielle Qiu Yun Jiang and Tai Liang Guo

Toxics, 2024, 12, 39
DOI: 10.3390/toxics12010039

Liquid Crystal Monomers Released from LCD Displays Accumulate in Endangered Marine Cetaceans Triggering Health Concerns

Danyang Tao, Chengzhang Li, Yajing Sun, Yuefei Ruan, Qianqian Jin, Jiaji Sun, Yichun Lu, Brian C. W. Kot, Paul K. S. Lam, Fengchang Wu, Jia He, John P. Giesy, Kurunthachalam Kannan, Bo Liang, Wenhua Liu, Lin Zhang, Yunsong Mu, Kenneth M. Y. Leung and Yuhe He

Environ. Sci. Technol., 2026, 60, 7437
DOI: 10.1021/acs.est.5c17767

Towards a sustainable rice husk ash-derived solid-phase extraction: Perfluoroalkyl substances as probe contaminants of waters

Petra Bianchini, Francesca Merlo, Mirko Prato, Silvia Dante, Andrea Serra, Guido Premoli, Antonella Profumo and Andrea Speltini

Journal of Chromatography Open, 2024, 6, 100165
DOI: 10.1016/j.jcoa.2024.100165

Sex specificity in associations between exposure to a mixture of per and poly-fluoroalkyl substances and anxiety among US adults

Xiaoguo Hua, Rui Hu, Cai Chen, Jiangjie Sun, Xiqiu Feng and Xiujun Zhang

J Expo Sci Environ Epidemiol, 2025, 35, 578
DOI: 10.1038/s41370-024-00741-3

The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia

Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan and Tatjana Rundek

Alzheimer's & Dementia, 2025, 21
DOI: 10.1002/alz.70226

Perfluorooctanoic acid disrupts thyroid hormone biosynthesis by altering glycosylation of Na+/I− symporter in larval zebrafish

Zhenzhen Cai, Guangdi Zhou, Xiaogang Yu, Yatao Du, Qiuhong Man and Weiye Charles Wang

Ecotoxicology and Environmental Safety, 2025, 297, 118249
DOI: 10.1016/j.ecoenv.2025.118249

Highly Sensitive Turn-On Detection of Perfluorooctanoic Acid by a Tb(III)-Based Coordination Polymer

Enting Xu, Chanreingam Long, Yuchen Qiao, Zhonghang Chen, Xuemei Yang and Peng Ren

Inorg. Chem., 2025, 64, 19697
DOI: 10.1021/acs.inorgchem.5c03097

Impacts of Environmental Pollution on Brain Tumorigenesis

Cristina Pagano, Giovanna Navarra, Laura Coppola, Beatrice Savarese, Giorgio Avilia, Antonella Giarra, Giovanni Pagano, Alessandra Marano, Marco Trifuoggi, Maurizio Bifulco and Chiara Laezza

IJMS, 2023, 24, 5045
DOI: 10.3390/ijms24055045

Separation of per- and polyfluorinated alkyl substances (PFAS) by means of anion exchange chromatography and study of their retention behavior

Jumana Khoury and Andreas Seubert

Journal of Chromatography A, 2025, 1758, 466192
DOI: 10.1016/j.chroma.2025.466192

Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort

Xin-xin Gao, Qian-lin Zuo, Xi-hang Fu, Ling-ling Song, Man-qiu Cen and Jing Wu

Environmental Research, 2023, 236, 116812
DOI: 10.1016/j.envres.2023.116812

Perfluorooctane Sulfonate (PFOS) Negatively Impacts Prey Capture Capabilities in Larval Zebrafish

Josiah D. Zoodsma, Chanita Boonkanon, Logan Running, Rehman Basharat, G. Ekin Atilla-Gokcumen, Diana S. Aga and Howard I. Sirotkin

Environmental Toxicology and Chemistry, 2023, 43, 847
DOI: 10.1002/etc.5819

Stereoselective Bioconcentration and Neurotoxicity of Perfluoroethylcyclohexane Sulfonate in Marine Medaka

Qi Wang, Yuefei Ruan, Yetong Shao, Linjie Jin, Naiyu Xie, Meng Yan, Lianguo Chen, Daniel Schlenk, Kenneth M. Y. Leung and Paul K. S. Lam

Environ. Sci. Technol., 2024, 58, 12933
DOI: 10.1021/acs.est.4c03571

Umbilical Cord Serum Long Chain Perfluorinated Carboxylic Acids Associated with Decreased Neurodevelopment in Toddlers: Findings from Smbcs Study

Boya Zhang, Zheng Wang, Jiming Zhang, Yiming Dai, Lei Zhang, Jianqiu Guo, Xiaojuan Qi, Xiuli Chang, Chunhua Wu and Zhijun ZHOU

SSRN Journal, 2022
DOI: 10.2139/ssrn.4192385

Network toxicology and immune-metabolic dysregulation: linking per- and polyfluoroalkyl substances exposure to osteoarthritis pathogenesis

Qian Zhang, Wenqi Zhang, Zhuchen Liu, Chunyu Luo, Ning Han, Weixin Cai and Jiaxing Liu

Toxicology Research, 2025, 14
DOI: 10.1093/toxres/tfaf077

Assessing construction and demolition wood-derived biochar for in-situ per- and polyfluoroalkyl substance (PFAS) removal from landfill leachate

Allison Cerlanek, Yalan Liu, Nicole Robey, Alina S. Timshina, John A. Bowden and Timothy G. Townsend

Waste Management, 2024, 174, 382
DOI: 10.1016/j.wasman.2023.12.017

Observational suspected adverse drug reaction profiles of fluoro-pharmaceuticals and potential mimicry of per- and polyfluoroalkyl substances (PFAS) in the United Kingdom

Banurja Balasubramaniam, Alan M. Jones and Sarah Nanzigu

PLoS One, 2025, 20, e0331286
DOI: 10.1371/journal.pone.0331286

RETRACTED: Association between per- and polyfluoroalkyl substances (PFAS) and depression in U.S. adults: A cross-sectional study of NHANES from 2005 to 2018

Wensen Yi, Lihui Xuan, Hesham M.H. Zakaly, Vladimir Markovic, Justyna Miszczyk, Hua Guan, Ping-Kun Zhou and Ruixue Huang

Environmental Research, 2023, 238, 117188
DOI: 10.1016/j.envres.2023.117188

Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations

Martin L. Pall

Brain Sciences, 2024, 14, 454
DOI: 10.3390/brainsci14050454

Effective removal of perfluorooctanoic acid from water using PVA@UiO-66-NH2/GO composite materials via adsorption

Vu Van Thang, Nguyen Tran Duy Nguyen, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi, Yasser Vasseghian and Sang-Woo Joo

Journal of Environmental Management, 2024, 368, 122248
DOI: 10.1016/j.jenvman.2024.122248

Poly- and per-fluoroalkyl substances toxicity on skeletal and cognitive well-being: a comprehensive review

Vikas C. Roy, Rajni Bala and Sakshi Mehta

Journal of Environmental Science and Health, Part C, 2025, 43, 159
DOI: 10.1080/26896583.2025.2460884

Exposure to perfluoroalkyl and polyfluoroalkyl substances and pediatric obesity: a systematic review and meta-analysis

Brianna Frangione, Sapriya Birk, Tarek Benzouak, Laura A. Rodriguez-Villamizar, Fatima Karim, Rose Dugandzic and Paul J. Villeneuve

Int J Obes, 2024, 48, 131
DOI: 10.1038/s41366-023-01401-6

Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort

Carly V. Goodman, Christine Till, Rivka Green, Jana El-Sabbagh, Tye E. Arbuckle, Richard Hornung, Bruce Lanphear, Jean R. Seguin, Linda Booij, Mandy Fisher, Gina Muckle, Maryse F. Bouchard and Jillian Ashley-Martin

Neurotoxicology and Teratology, 2023, 98, 107181
DOI: 10.1016/j.ntt.2023.107181

Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study

Boya Zhang, Zheng Wang, Jiming Zhang, Yiming Dai, Jiayun Ding, Jianqiu Guo, Xiaojuan Qi, Chunhua Wu and Zhijun Zhou

Environment International, 2024, 187, 108720
DOI: 10.1016/j.envint.2024.108720

Environmental occurance, human exposure, and metabolism of per- and polyfluoroalkyl substances—a review

Yifei Cao, Yuru Huang, Ying Ma, Jun Nie, Chao Hu, Yingshu Chen, Juntao Xu and Liping Lu

Environ. Res. Commun., 2025, 7, 052001
DOI: 10.1088/2515-7620/add0fa

Metabolic Perturbations Associated with an Exposure Mixture of Per- and Polyfluoroalkyl Substances in the Atlanta African American Maternal-Child Cohort

Donghai Liang, Kaitlin R. Taibl, Anne L. Dunlop, Dana Boyd Barr, P. Barry Ryan, Todd Everson, Anke Huels, Youran Tan, Parinya Panuwet, Kurunthachalam Kannan, Carmen Marsit, Dean P. Jones and Stephanie M. Eick

Environ. Sci. Technol., 2023, 57, 16206
DOI: 10.1021/acs.est.3c04561

Carbon-chain length determines the binding affinity and inhibitory strength of per- and polyfluoroalkyl substances on human and rat steroid 5α-reductase 1 activity

Rong Cui, Lei Ye, Xinyi Qiao, Shaowei Wang, Ke Zheng, Jin Yang, Ren-shan Ge, Han Lin and Yiyan Wang

Chemico-Biological Interactions, 2024, 394, 110987
DOI: 10.1016/j.cbi.2024.110987

Fluorine-Free Hydrophobic Polymer Brushes for Self-Healing Coatings

Annemieke van Dam, Sidharam P. Pujari, Maarten M. J. Smulders and Han Zuilhof

ACS Appl. Nano Mater., 2024, 7, 19737
DOI: 10.1021/acsanm.4c03988

Fluorescence Turn-on Detection of Perfluorooctanoic Acid (PFOA) by Perylene Diimide-Based Metal–Organic Framework

Rana Dalapati, Matthew Hunter, Mostakim SK, Xiaomei Yang and Ling Zang

ACS Appl. Mater. Interfaces, 2024, 16, 32344
DOI: 10.1021/acsami.4c03389

Prenatal exposure to per- and polyfluoroalkyl substances and child behavioral problems

Jeong Weon Choi, Jiwon Oh, Deborah H. Bennett, Antonia M. Calafat, Rebecca J. Schmidt and Hyeong-Moo Shin

Environmental Research, 2024, 251, 118511
DOI: 10.1016/j.envres.2024.118511

Occurrence, spatial distribution, and risk assessment of per- and polyfluoroalkyl substances in soil and groundwater of a petrochemical industrial park in China

Qitao Lei, Lin Niu, Zhi Tang, Yali Shi, Xiaoli Zhao and Yaqi Cai

Environmental Pollution, 2025, 385, 127064
DOI: 10.1016/j.envpol.2025.127064

Novel Insights into the Distribution and Effects of Perfluorooctanesulfonic acid (PFOS) in the Nervous System of a Frog Tadpole Model by Mass Spectrometry Imaging

Rikke Poulsen, Emma M. Field, Angela M. Jackson, Haley Kuecks-Winger, Anita A. Thambirajah, David R. Goodlett, Caren C. Helbing and Helena Pětrošová

Environ. Sci. Technol., 2026, 60, 3121
DOI: 10.1021/acs.est.5c17483

Mechanistic insights into PFAS derivatives-induced coronary heart disease and atherosclerotic renal artery stenosis via integrated network toxicology and molecular modeling

Jinxuan Chai, Yan Wang, Cheng Zhang, Yuelu Wang, Ao Xue and Wei Jie

Toxicology Research, 2026, 15
DOI: 10.1093/toxres/tfaf190

Exploring the impact of PFAS exposure and sleep duration on kidney stone formation in the U.S. population

Jianbai Chen, Zhiming Zhang, Gongquan Xu, Qisheng Tang, Zhiyong Nie, Jianxin Qiu and Xiaoping Gao

Front. Public Health, 2025, 13
DOI: 10.3389/fpubh.2025.1606191

Per- and polyfluoroalkyl substances and sleep health in U.S. adults, NHANES 2005–2014

Pengfei Guo, Zhihao Jin, Giselle Bellia, Jiajun Luo, Kosuke Inoue, Krystal J. Godri Pollitt, Nicole C. Deziel and Zeyan Liew

Environmental Research, 2023, 237, 117092
DOI: 10.1016/j.envres.2023.117092

Differential regulations of neural activity and survival in primary cortical neurons by PFOA or PFHpA

Moon Yi Ko, Heejin Park, Sun-Hwa Chon, Yong-Bum Kim, Sin-Woo Cha, Byoung-Seok Lee, Sung-Ae Hyun and Minhan Ka

Chemosphere, 2024, 352, 141379
DOI: 10.1016/j.chemosphere.2024.141379

Efficient analysis of metabolites of industrial additives in cerebrospinal fluids

Ruihe Jin, Jun Shi, Jing Yang, Ge Yin, Chunjie Xia, Xiongwei Wang, Min Liu and Yan Wu

Environ Chem Lett, 2024, 22, 997
DOI: 10.1007/s10311-024-01705-7

Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish

Roxanne Bérubé, Matthew K LeFauve, Aicha Khalaf, Darya Aminioroomi and Christopher D Kassotis

Environmental Toxicology and Chemistry, 2025, 44, 1923
DOI: 10.1093/etojnl/vgaf099

Prenatal exposure to per- and polyfluoroalkyl substances and childhood executive function and behavioral difficulties at age 7: evidence from the Shanghai birth cohort study

Xiaoqing He, Ruisi Wu, Wen Jiang, Ying Tian, Jun Zhang and Yun Huang

Environment International, 2025, 202, 109687
DOI: 10.1016/j.envint.2025.109687

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Xing Zhang, Jodi A. Flaws, Michael J. Spinella and Joseph Irudayaraj

Toxics, 2022, 11, 32
DOI: 10.3390/toxics11010032

Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions

Bhagyashree Bharal, Chanda Ruchitha, Paarth Kumar, Rukmani Pandey, Mahesh Rachamalla, Som Niyogi, Ravi Naidu and Ravinder K. Kaundal

Science of The Total Environment, 2024, 955, 176941
DOI: 10.1016/j.scitotenv.2024.176941

Relationship between PFAS and attention-deficit/hyperactivity disorder or autism spectrum disorder: Epidemiological and experimental evidence

Keyue Wu, Aoxue Tang, Xing Zhang, Shun Zhou, Nana Wu, Junyan Tao, Yun Chen, Guanghong Yang, Hao Zhou and Mingdan You

Ecotoxicology and Environmental Safety, 2025, 302, 118519
DOI: 10.1016/j.ecoenv.2025.118519

Piezo-Catalytic Degradation of PFASs: Emerging Trends, Mechanistic Insights, and Future Directions

Dhananjoy Mondal and Indrajit Chakraborty

Langmuir, 2026, 42, 2337
DOI: 10.1021/acs.langmuir.5c04205

Environmental pollutant-induced cholinergic disruption: Advances and perspectives in mechanistic insights, target heterogeneity, and neurotoxic synergy

Wei Li, Ke Gao and Liping Lu

Ecotoxicology and Environmental Safety, 2025, 308, 119470
DOI: 10.1016/j.ecoenv.2025.119470

Assessment of PFAS contamination in agricultural soils: Non-target identification of precursors, fluorine mass balance and microcosm studies

Joel Fabregat-Palau, Jonathan Zweigle, Dominik Renner, Christian Zwiener and Peter Grathwohl

Journal of Hazardous Materials, 2025, 490, 137798
DOI: 10.1016/j.jhazmat.2025.137798

Life Cycle Assessment of PFAS Removal from Landfill Leachate at the Laboratory Scale

Federico Bedogni, Francesco Arfelli, Matteo Picchietti, Massimo Facchini, Luca Ciacci, Daniele Cespi and Fabrizio Passarini

Environments, 2026, 13, 35
DOI: 10.3390/environments13010035

PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies

Sandra India-Aldana, Meizhen Yao, Vishal Midya, Elena Colicino, Leda Chatzi, Jaime Chu, Chris Gennings, Dean P. Jones, Ruth J. F. Loos, Veronica W. Setiawan, Mathew Ryan Smith, Ryan W. Walker, Dinesh Barupal, Douglas I. Walker and Damaskini Valvi

Curr Pollution Rep, 2023, 9, 510
DOI: 10.1007/s40726-023-00269-4

Associations between per- and polyfluoroalkyl substances exposure and renal function as well as poor prognosis in chronic kidney disease patients

Jiayin Wang, Tianyun Gao, Xiaohua Li and Ling Pan

Renal Failure, 2025, 47
DOI: 10.1080/0886022X.2025.2520903

Developing an interpretable machine learning predictive model of chronic obstructive pulmonary disease by serum PFAS concentration

Xiaomei Shao, Ling Zhang, Yuting Wang, Youmei Ying and Xueqin Chen

Front. Public Health, 2025, 13
DOI: 10.3389/fpubh.2025.1602566

Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons

Shichen Wu, Junkai Xie, Han Zhao, Xihui Zhao, Oscar F. Sánchez, Jean-Christophe Rochet, Jennifer L. Freeman and Chongli Yuan

Environment International, 2024, 190, 108914
DOI: 10.1016/j.envint.2024.108914

Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins

Shiwen Li, Jesse A. Goodrich, Jiawen Carmen Chen, Elizabeth Costello, Emily Beglarian, Jiawen Liao, Tanya L. Alderete, Damaskini Valvi, Brittney O. Baumert, Sarah Rock, Sandrah P. Eckel, Rob McConnell, Frank D. Gilliland, Zhanghua Chen, David V. Conti, Lida Chatzi and Max Aung

Environmental Advances, 2024, 17, 100585
DOI: 10.1016/j.envadv.2024.100585

Impact of Textile-Derived Micro- and Nanoplastics on Brain Health: An Emerging Environmental Risk

Mina Bayattork, Muntajin Rahman, Md Imran Hossain, Yi Zhang, Abu Naser Md Ahsanul Haque, Bonglee Kim and Maryam Naebe

Environ. Sci. Technol., 2026, 60, 2863
DOI: 10.1021/acs.est.5c10338

Electrosorption-Driven Remediation of PFAS-Contaminated Water Using a MXene Nanosheet-PEDOT:PSS Adsorbent

Bishwash Shrestha, Mohammadamin Ezazi, Sungbaek Seo, Uk Sim, Duck Hyun Lee and Gibum Kwon

ACS Appl. Eng. Mater., 2024, 2, 368
DOI: 10.1021/acsaenm.3c00686

PFASs in Cerebrospinal Fluids and Blood–CSF Barrier Permeability in Patients with Cognitive Impairment

Xiaowen Hong, Lin Tao, Liyan Guo, Lin Luo, Jia Lv, Ruonan Li, Jiayue Hu, Chang Gao, Hua Wang, De-Xiang Xu, Zhao-Zhao Cheng, Bi-Xian Mai, Qiqiang Tang and Yichao Huang

Environ. Sci. Technol., 2024, 58, 5129
DOI: 10.1021/acs.est.3c10511

Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review

Pietro Martano, Samira Mahdi, Tong Zhou, Yasmin Barazandegan, Rebecca Iha, Hannah Do, Joel Burken, Paul Nam, Qingbo Yang and Ruipu Mu

Toxics, 2025, 13, 658
DOI: 10.3390/toxics13080658

Impact of Salinity and Temperature on Removal of PFAS Species from Water by Aeration in the Absence of Additional Surfactants: A Novel Application of Green Chemistry Using Adsorptive Bubble Fractionation

Anthony L. Morrison, Vladimir Strezov, Robert K. Niven, Mark P. Taylor, Scott P. Wilson, Jianlong Wang, David J. Burns and Peter J. C. Murphy

Ind. Eng. Chem. Res., 2023, 62, 5635
DOI: 10.1021/acs.iecr.3c00150

Impact of prenatal exposure to per- and polyfluoroalkyl substances on developmental delays in 4-year-old children: The Japan Environment and Children’s study

Mariko Itoh, Sumitaka Kobayashi, Hiroyoshi Iwata, Yu Ait Bamai, Rahel Mesfin Ketema, Takeshi Yamaguchi, Keiko Yamazaki, Naomi Tamura, Maki Tojo, Satoshi Suyama, Sachiko Itoh, Chihiro Miyashita, Yasuaki Saijo, Yoshiya Ito, Shoji F. Nakayama, Michihiro Kamijima and Reiko Kishi

Environment International, 2025, 198, 109434
DOI: 10.1016/j.envint.2025.109434

The Influence of Adiposity Levels on the Relation between Perfluoroalkyl Substances and High Depressive Symptom Scores in Czech Adults

Geraldo Neto, Martin Bobak, Juan P. Gonzalez-Rivas and Jana Klanova

Toxics, 2023, 11, 946
DOI: 10.3390/toxics11110946

Occurrence and biomagnification of perfluoroalkyl substances (PFAS) in Lake Michigan fishes

Daniele A. Miranda, Alison M. Zachritz, Heather D. Whitehead, Shannon R. Cressman, Graham F. Peaslee and Gary A. Lamberti

Science of The Total Environment, 2023, 895, 164903
DOI: 10.1016/j.scitotenv.2023.164903

Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: The Japan Environment and Children’s Study

Yonghang Lai, Shoji F. Nakayama, Yukiko Nishihama and Tomohiko Isobe

Ecotoxicology and Environmental Safety, 2025, 294, 118107
DOI: 10.1016/j.ecoenv.2025.118107

Malic Acid Improves Behavioral, Biochemical, and Molecular Disturbances in the Hypothalamus of Stressed Rats

Khaled M. M. Koriem and Hatem A. K. Tharwat

J. Integr. Neurosci., 2023, 22
DOI: 10.31083/j.jin2204098

Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish

Yatao Du, Qin Li, Guangdi Zhou, Zhenzhen Cai, Qiuhong Man and Weiye Charles Wang

Science of The Total Environment, 2024, 917, 170408
DOI: 10.1016/j.scitotenv.2024.170408

Deriving Membrane–Water and Protein–Water Partition Coefficients from In Vitro Experiments for Per- and Polyfluoroalkyl Substances (PFAS)

Ruiwen Chen, Derek Muensterman, Jennifer Field and Carla Ng

Environ. Sci. Technol., 2025, 59, 82
DOI: 10.1021/acs.est.4c06734

Toward sustainable PFAS elimination: Engineering TiO2 photocatalysts for complete mineralization and defluorination

Zakariyya Uba Zango, Khalid Hassan Ibnaouf, Abdurrashid Haruna, Muhammad Abubakar Lawal, Ismael A. Wadi, Moez A. Ibrahem, Fatima Bukola Shittu and Haruna Adamu

Journal of Science: Advanced Materials and Devices, 2025, 10, 101041
DOI: 10.1016/j.jsamd.2025.101041

Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish

Eun Ki Min, Hyojin Lee, Eun Ji Sung, Seong Woo Seo, Myungha Song, Seungjun Wang, Seong Soon Kim, Myung Ae Bae, Tae-Young Kim, Sangkyu Lee and Ki-Tae Kim

Journal of Hazardous Materials, 2023, 457, 131714
DOI: 10.1016/j.jhazmat.2023.131714

Identification of the mechanisms underlying per- and polyfluoroalkyl substance-induced hippocampal neurotoxicity as determined by network pharmacology and molecular docking analyses

Shirui Li, Zhihui Gao, Meihan Zhong, Haoran Bi and Jianan Li

Toxicology Research, 2023, 12, 1126
DOI: 10.1093/toxres/tfad104

Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review

Shenpan Li, Shuangjian Qin, Huixian Zeng, Weichun Chou, Anna Oudin, Katja M. Kanninen, Pasi Jalava, Guanghui Dong and Xiaowen Zeng

Eco-Environment & Health, 2024, 3, 476
DOI: 10.1016/j.eehl.2024.08.002

Prenatal Exposure to Legacy and Alternative Per- and Polyfluoroalkyl Substances and Neuropsychological Development Trajectories over the First 3 Years of Life

Qing-Qing Li, Jinbo Huang, Dan Cai, Wei-Chun Chou, Mohammed Zeeshan, Chu Chu, Yang Zhou, Lizi Lin, Hui-Min Ma, Cuilan Tang, Minli Kong, Yanqi Xie, Guang-Hui Dong and Xiao-Wen Zeng

Environ. Sci. Technol., 2023, 57, 3746
DOI: 10.1021/acs.est.2c07807

Sex, age, and species differences of perfluorooctanoic acid modeled by flow- versus permeability-limited physiologically-based pharmacokinetic models

Go-Wun Choi, Dong Wook Kang, Ju Hee Kim, Seok-jin Cho, Yong-Bok Lee, In-Ho Kwon and Hea-Young Cho

Toxicology, 2024, 505, 153806
DOI: 10.1016/j.tox.2024.153806

Differences in Toxicokinetics and Maternal Transfer between Lipophilic and Proteinophilic Halogenated Organic Pollutants in Laying Hens

Xiao-Jun Luo, Qun-Jie Feng, Chu-Hong Zhu, Xi Chen, Peng-Peng Chen, Yan-Hong Zeng and Bi-Xian Mai

Environ. Health, 2024, 2, 712
DOI: 10.1021/envhealth.4c00053

ATF4 participates in perfluorooctane sulfonate-induced neurotoxicity by regulating ferroptosis

Fangling Zhu, Nan Wang, Yichao Xu, Xiaohua Su, Ziliang Deng, Yongdui Ruan, Daifan Lin, Yun Chen, Zhuoni Kuang, Guanlin Chen, Chengcheng Yu, Xiaoxuan Ling and Linhua Liu

Ecotoxicology and Environmental Safety, 2025, 299, 118303
DOI: 10.1016/j.ecoenv.2025.118303

PFAS: exploration of neurotoxicity and environmental impact

Mrunal Nannaware, Neelaambhigai Mayilswamy and Balasubramanian Kandasubramanian

Environ Sci Pollut Res, 2024, 31, 12815
DOI: 10.1007/s11356-024-32082-x

Dual H–O Bond Relaxation Reveals Hydration–Aggregation Dynamics of PFAS at Aqueous Interfaces: Many-Body Cooperativity

Hengxin Fang, Yue Shen, Yong Zhou, Sanmei Wang, Chunyang Nie, Nan Guan, Chang Q. Sun and Biao Wang

J. Phys. Chem. Lett., 2025, 16, 11009
DOI: 10.1021/acs.jpclett.5c02877

Elucidating the Mechanism of PFOA Regulation of Biofilms in Aquatic Systems at Gene and Metabolic Levels

Yixia Yang, Qi Li, Yunxing Xiao, Yifan Shen, Yumiao Zhang, Weizhen Zhang, Ningfei Lei, Xiangjun Pei and Yanhua Xie

Environ. Sci. Technol., 2025, 59, 24931
DOI: 10.1021/acs.est.5c06467

Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach

Courtney C. Carignan, Rachel A. Bauer, Andrew Patterson, Thep Phomsopha, Eric Redman, Heather M. Stapleton and Christopher P. Higgins

Environ. Sci. Technol., 2023, 57, 7950
DOI: 10.1021/acs.est.2c09852

Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system

Maria Carolina Peixoto-Rodrigues, José Raphael Monteiro-Neto, Timea Teglas, Michal Toborek, Natalia Soares Quinete, Rachel Ann Hauser-Davis and Daniel Adesse

Journal of Hazardous Materials, 2025, 485, 136832
DOI: 10.1016/j.jhazmat.2024.136832

Environmental occurrence of perfluorooctanesulfonic acid from sulfluramid-based ant bait usage and its ecotoxicological risks

Yago Guida, Robson Rolland Monticelli Barizon, Fábio Kummrow, Dhoone Menezes-Sousa, Márcia Regina Assalin, Maria Aparecida Rosa, Ricardo Antônio Almeida Pazianotto and José Tadeu de Oliveira Lana

Environmental Research, 2025, 279, 121851
DOI: 10.1016/j.envres.2025.121851

Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid models

Ziyu Ji, Liqun Chen and Dong Ming

Toxicology, 2026, 522, 154408
DOI: 10.1016/j.tox.2026.154408

Predicting depression using serum perfluoroalkyl and polyfluoroalkyl substances levels via interpretable machine learning

Hui Jin, Yang Wen, Shuai Luo, Cong Wang, Yi-Hao Liu, Yi-Yue Yang, Lie Zhou, Yun-Fei Mu, Xiaoyun Zhang and Mao-sheng Ran

Journal of Affective Disorders, 2025, 391, 119976
DOI: 10.1016/j.jad.2025.119976

Emerging eco-friendly technologies for remediation of Per- and poly-fluoroalkyl substances (PFAS) in water and wastewater: A pathway to environmental sustainability

Timothy Prince Chidike Ezeorba, Emmanuel Sunday Okeke, Chidiebele Emmanuel Nwankwo, Stephen Chijioke Emencheta, Adebisi Esther Enochoghene, Veronica Chisom Okeke and Vincent E.O. Ozougwu

Chemosphere, 2024, 364, 143168
DOI: 10.1016/j.chemosphere.2024.143168

Study on the Molecular Mechanism of Interaction Between Perfluoroalkyl Acids and PPAR by Molecular Docking

Renli Wei, Huiping Xiao, Jie Fu, Yin Luo and Pengfei Wang

Toxics, 2026, 14, 67
DOI: 10.3390/toxics14010067

Structural Insights into PFAS-β-Lactoglobulin-Binding Mechanism Mediating PFAS Toxicity

Shalja Verma, Anika Singh, Randhal S. Ramirez Orozco, Lela Vukovic, Mahesh Narayan and Pravindra Kumar

Biochemistry, 2026, 65, 532
DOI: 10.1021/acs.biochem.5c00606

Sustainable Remediation Strategies and Technologies of Per- and Polyfluoroalkyl Substances (PFAS)-Contaminated Soils: A Critical Review

Rosario Napoli, Filippo Fazzino, Federico G. A. Vagliasindi and Pietro P. Falciglia

Sustainability, 2025, 17, 6635
DOI: 10.3390/su17146635

Research on the Neurotoxic Effects of ‘Forever Chemicals’ Is Just Emerging

Gina Shaw

Neurology Today, 2024, 24
DOI: 10.1097/01.NT.0001007280.76489.e5

Porous Styrene Functionalized β-Cyclodextrin Beads for Organic Contaminant Removal from Wastewater

Emma F. Shapiro, Zhi-Wei Lin, Gray H. Harlan, Disraëli Noami Marie-Theresse Kusmus, Clare L. McGillis, William R. Dichtel and Aaron I. Packman

ACS EST Eng., 2026
DOI: 10.1021/acsestengg.5c01037

A mini-review on the health risks associated with sodium p-perfluorous nonenoxybenzene sulfonate exposure

Shi Qi Xu and De Xin Dang

Reviews on Environmental Health, 2025, 40, 652
DOI: 10.1515/reveh-2025-0055

Absorption and Tissue Distribution of Environmental Pollutant HFPO-DA, and Its Effect on Hepatic Lipid Metabolism Reprogramming in Mice

Jie Peng, Wei Jiang, Zi Long, Yueying Cui, Guizhen Zhu, Rui Liu, Deqin Kong, Weihua Yu, Yuliang Li and Chunxu Hai

Toxics, 2025, 13, 850
DOI: 10.3390/toxics13100850

Insights into PFAS environmental fate through computational chemistry: A review

Bruno Bezerra de Souza and Jay Meegoda

Science of The Total Environment, 2024, 926, 171738
DOI: 10.1016/j.scitotenv.2024.171738

Porous Pillar[5]arene-Based Polymers for Efficient Removal of Perfluorinated Pollutants from Aqueous Phases

Shujie Lin, Ziliang Zhang, Zihan Fang, Di Gao, Longming Chen, Chengyang Tian, Junyi Chen and Qingbin Meng

ACS Appl. Polym. Mater., 2024, 6, 13300
DOI: 10.1021/acsapm.4c02628

Decreased levels of perfluoroalkyl substances in patients receiving hemodialysis treatment

Jih-Kai Huang, Yun-Shiuan Chuang, Ping-Hsun Wu, Chi-Jung Tai, Jye-Ru Lin, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Chi Hsu, Ming-Tsang Wu, Samira Salihovic and Yi-Ting Lin

Science of The Total Environment, 2023, 896, 165184
DOI: 10.1016/j.scitotenv.2023.165184

A State-of-the-Science Review of Interactions of Per- and Polyfluoroalkyl Substances (PFAS) with Renal Transporters in Health and Disease: Implications for Population Variability in PFAS Toxicokinetics

Shan Niu, Yuexin Cao, Ruiwen Chen, Megha Bedi, Alison P. Sanders, Alan Ducatman and Carla Ng

Environ Health Perspect, 2023, 131
DOI: 10.1289/EHP11885

Poly- and perfluoroalkyl substances (PFASs) in amphibians and reptiles – exposure and health effects

Slawomir Gonkowski and Valeria Ochoa-Herrera

Aquatic Toxicology, 2024, 270, 106907
DOI: 10.1016/j.aquatox.2024.106907

The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)

Megan E. Solan and Ramon Lavado

J of Applied Toxicology, 2022, 42, 1298
DOI: 10.1002/jat.4270

Predicting Exposure to Perfluorinated Alkyl Substances (PFAS) among US Infants

Andrea B. Kirk, Kelsey Marie Plasse, Karli C. Kirk, Clyde F. Martin and Gamze Ozsoy

IJERPH, 2022, 19, 8402
DOI: 10.3390/ijerph19148402

Correlation analysis between per-fluoroalkyl and poly-fluoroalkyl substances exposure and depressive symptoms in adults: NHANES 2005–2018

Xiaoyi Sun, Xupu Yang, Yizhe Zhang, Yi Liu, Fang Xiao, Huicai Guo and Xuehui Liu

Science of The Total Environment, 2024, 906, 167639
DOI: 10.1016/j.scitotenv.2023.167639

Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models

Renee Owen, Gabriel de Macedo, Jana Nerlich, Ilka Scharkin, Kristina Bartmann, Jonas Döbler, Beatrice Engelmann, Ulrike E Rolle-Kampczyk, David Leuthold, Sebastian Gutsfeld, Nicole Schweiger and Tamara Tal

Toxicological Sciences, 2025, 207, 449
DOI: 10.1093/toxsci/kfaf101

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants

Min Li, Yuanlin Ma, Wenli Cheng, Luyun Zhang, Cheng Zhou, Wenji Zhang and Wenjuan Zhang

Front. Public Health, 2023, 11
DOI: 10.3389/fpubh.2023.1136454

Exposure to environmentally relevant concentration of sodium p-perfluorous nonenoxybenzene sulfonate is associated with aberrant barbering behavior in diabetic mice

De Xin Dang and Shaoyong Xu

Ecotoxicology and Environmental Safety, 2026, 311, 119906
DOI: 10.1016/j.ecoenv.2026.119906

Per- and Polyfluoroalkyl Substances (PFAS) Affect Female Reproductive Health: Epidemiological Evidence and Underlying Mechanisms

Rui Qu, Jingxuan Wang, Xiaojie Li, Yan Zhang, Tailang Yin and Pan Yang

Toxics, 2024, 12, 678
DOI: 10.3390/toxics12090678

Metabolome informs about the chemical exposome and links to brain health

Matej Orešič, Naama Karu, Haoqi Nina Zhao, Arthur Moseley, Thomas Hankemeier, David S. Wishart, Pieter C. Dorrestein, Oliver Fiehn, Tuulia Hyötyläinen and Rima Kaddurah Daouk

Environment International, 2025, 203, 109741
DOI: 10.1016/j.envint.2025.109741

Biological pathways of per- and polyfluoroalkyl substances (PFAS): A critical review of cellular and molecular toxicity mechanisms

McKenna Dunmyer, Jack Welchert, Christopher I. Olivares and Vasiliki Karanikola

Journal of Hazardous Materials, 2026, 505, 141480
DOI: 10.1016/j.jhazmat.2026.141480

Evaluation and validation of methodologies for the extraction of per- and polyfluoroalkyl substances (PFASs) in serum of birds and mammals

Drew Szabo, Jaye Marchiandi, Mark P. Green, Raoul A. Mulder and Bradley O. Clarke

Anal Bioanal Chem, 2022, 414, 3017
DOI: 10.1007/s00216-022-03962-3

Nanomaterial-enhanced membranes for PFAS remediation: Mechanistic insights, technology performance, and pathways to scalable implementation

Junkai Wang, Umma Habiba, M.S. Reza, I.M.R. Fattah, Ali Altaee and T.M.I. Mahlia

Journal of Water Process Engineering, 2026, 81, 109341
DOI: 10.1016/j.jwpe.2025.109341

Impact of per- and polyfluorinated alkyl substances (PFAS) on the marine environment: Raising awareness, challenges, legislation, and mitigation approaches under the One Health concept

Lada Lukić Bilela, Inga Matijošytė, Jokūbas Krutkevičius, Diogo A.M. Alexandrino, Ivo Safarik, Juris Burlakovs, Susana P. Gaudêncio and Maria F. Carvalho

Marine Pollution Bulletin, 2023, 194, 115309
DOI: 10.1016/j.marpolbul.2023.115309

Environmental behaviors, biotransformation, and toxicological risks of PFPiAs: A comprehensive review of an emerging PFAS

Xihua Wang, Qinya lv, Y. Jun Xu, Rongbing Fu, Yueqing Xie, Chaomeng Dai, Nianqing Zhou, Yaqiang Wei, Xuming Ji, Boyang Mao, Shunqing Jia and Zejun Liu

Science of The Total Environment, 2025, 996, 180119
DOI: 10.1016/j.scitotenv.2025.180119

Exposure to PFOA, PFOS, and PFHxS induces Alzheimer's disease-like neuropathology in cerebral organoids

Shiya Lu, Xizhi Zhu, Pinli Zeng, Linxia Hu, Yan Huang, Xinhua Guo, Qiqi Chen, Yantang Wang, Li Lai, Aiqin Xue, Yanli Wang, Zhiqiu Wang, Wenbo Song, Qian Liu, Guohui Bian, Jiayuan Li, Qian Bu and Xiaobo Cen

Environmental Pollution, 2024, 363, 125098
DOI: 10.1016/j.envpol.2024.125098

A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior

Hannah M. Starnes, Kylie D. Rock, Thomas W. Jackson and Scott M. Belcher

Front. Toxicol., 2022, 4
DOI: 10.3389/ftox.2022.881584

Association between PFAS exposure and attention processing in adolescent boys: a pilot study

Sharlene D. Newman and Yanyu Xiong

Front. Cognit., 2025, 4
DOI: 10.3389/fcogn.2025.1606956

Bile acids and apical sodium-dependent bile acid transporter impact per- and polyfluoroalkyl substances absorption: Evidence from in vivo and cross-sectional studies

Yiran Liang, Jing Zhan, Xiao Liu, Shumin Liang, Ruosi Li, Yinchuan Lv, Jingjing He and Jiaying Liu

Journal of Hazardous Materials, 2025, 499, 140138
DOI: 10.1016/j.jhazmat.2025.140138

Occurrence of per- and polyfluorinated substances, microplastics, pharmaceuticals and personal care products as emerging contaminants in landfill leachate: A review

Mojtaba Nouri Goukeh, Dennis Ssekimpi, Benhur K. Asefaw and Zhiming Zhang

Total Environment Engineering, 2025, 3, 100019
DOI: 10.1016/j.teengi.2025.100019

PFAS contamination and its rising toll on food security: A hidden global threat

Chinemerem Ruth Ohoro and Veronica M. Ngole-Jeme

Food Control, 2026, 180, 111611
DOI: 10.1016/j.foodcont.2025.111611

Prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopmental trajectories in the first two years of life

Bingjie Wu, Zhichao Yuan, Shiyang Li, Wen Jiang, Yun Huang, Shengju Yin, Liu Liu and Jun Zhang

Environment International, 2026, 207, 110011
DOI: 10.1016/j.envint.2025.110011

A genomic framework for evaluating the impact of per- and polyfluoroalkyl substances on bone health

Sixuan Liu, Senlin Luo, Xiaokun Zhao, Yinhuai Wang, Yi Peng, Jiachen Liu and Haiqing He

Environ Sci Eur, 2026, 38
DOI: 10.1186/s12302-025-01303-6

Effects of PFOA and emerging alternatives at environmental concentrations on murine- and human-derived microglia: A comparative study

Keyue Wu, Shun Zhou, Aoxue Tang, Junyan Tao, Yun Chen, Hao Zhou and Mingdan You

Environmental Research, 2026, 294, 123876
DOI: 10.1016/j.envres.2026.123876

PFASs in Soil: How They Threaten Human Health through Multiple Pathways and Whether They Are Receiving Adequate Concern

Yingna Xing, Qi Li, Xin Chen, Bin Huang, Lei Ji, Qiang Zhang, Xiaowen Fu, Tianyuan Li and Jianing Wang

J. Agric. Food Chem., 2023, 71, 1259
DOI: 10.1021/acs.jafc.2c06283

Prenatal Exposure to Perfluoroalkyl Substances and Cognitive and Neurobehavioral Development in Children at 6 Years of Age

Zhenzhen Xie, Hong Liang, Maohua Miao, Ziliang Wang, Yao Chen, Lan Yang, Yan Zhou, Wencheng Cao and Wei Yuan

Environ. Sci. Technol., 2023, 57, 8213
DOI: 10.1021/acs.est.2c06535

Neurodevelopmental toxicity and mechanism of chlorinated polyfluoroalkyl ether sulfonate alternative F-53B in pubertal male rats

Lu Sun, Yao Chen, Junyan Chen, Guanghua Mao, Weiwei Feng and Xiangyang Wu

Arch Toxicol, 2025, 99, 3787
DOI: 10.1007/s00204-025-04093-1

Managing PFAS in Sewage Sludge: Exposure Pathways, Impacts, and Treatment Innovations

Luoana Florentina Pascu, Valentina Andreea Petre, Ioana Antonia Cimpean, Iuliana Paun, Florinela Pirvu and Florentina Laura Chiriac

JoX, 2025, 15, 135
DOI: 10.3390/jox15040135

Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory

Nicolas van Larebeke, Bianca Cox, Sylvie Remy, Stefan Voorspoels, Elly Den Hond, Ann Colles, Martine Leermakers, Greet Schoeters and Veerle Verheyen

Environ Health, 2025, 24
DOI: 10.1186/s12940-025-01188-1

The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery

Hiroshi Komura, Reiko Watanabe and Kenji Mizuguchi

Pharmaceutics, 2023, 15, 2619
DOI: 10.3390/pharmaceutics15112619

Investigating the Mechanism of Neurotoxic Effects of PFAS in Differentiated Neuronal Cells through Transcriptomics and Lipidomics Analysis

Logan Running, Judith R. Cristobal, Charikleia Karageorgiou, Michelle Camdzic, John Michael N. Aguilar, Omer Gokcumen, Diana S. Aga and G. Ekin Atilla-Gokcumen

ACS Chem. Neurosci., 2024, 15, 4568
DOI: 10.1021/acschemneuro.4c00652

Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives

Jiawen Liu, Yanling Xie, Meihui Zhu, Zhiqiu Wang, Yan Huang, Xiaobo Cen and Qian Bu

Cell Biol Toxicol, 2026
DOI: 10.1007/s10565-026-10161-8

Identification of potential mechanisms of cognitive dysfunction induced by environmentally relevant PFAS mixture in male rats

Bing Li, Yinan Xu, Xueyan Guo, Meihui Wang, Xiaoyuan Li, Zhe Chen, Zhiwen Wei, Dong Ma and Keming Yun

Environment International, 2026, 208, 110093
DOI: 10.1016/j.envint.2026.110093

Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)

Sebastian Gutsfeld, Leah Wehmas, Ifeoluwa Omoyeni, Nicole Schweiger, David Leuthold, Paul Michaelis, Xia Meng Howey, Shaza Gaballah, Nadia Herold, Carolina Vogs, Carmen Wood, Luísa Bertotto, Gi-Mick Wu, Nils Klüver, Wibke Busch, Stefan Scholz, Jana Schor and Tamara Tal

Environ Health Perspect, 2024, 132
DOI: 10.1289/EHP13667

PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies

Andrea Rodríguez-Carrillo, Sylvie Remy, Gudrun Koppen, Natasha Wauters, Carmen Freire, Alicia Olivas-Martínez, Tessa Schillemans, Agneta Åkesson, Anteneh Desalegn, Nina Iszatt, Elly den Hond, Veerle Verheyen, Lucia Fábelová, Lubica Palkovicova Murinova, Susana Pedraza-Díaz, Argelia Castaño, José Vicente García-Lario, Bianca Cox, Eva Govarts, Kirsten Baken, Manuel Tena-Sempere, Nicolás Olea, Greet Schoeters and Mariana F. Fernández

Environmental Pollution, 2023, 335, 122214
DOI: 10.1016/j.envpol.2023.122214

Perfluorooctanoic acid and perfluorooctane sulfonate promote osteoclastogenesis in vitro through the activation of hemichannels

Sijia Yang, Mengyuan Chen, Di Yang, Furong Deng and Xinbiao Guo

Arch Toxicol, 2026, 100, 1109
DOI: 10.1007/s00204-025-04265-z

Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances

Meng-Yi Xie, Xiang-Fei Sun, Chen-Chou Wu, Guang-Long Huang, Po Wang, Zhi-Ying Lin, Ya-Wei Liu, Liang-Ying Liu and Eddy Y. Zeng

Journal of Hazardous Materials, 2023, 441, 129819
DOI: 10.1016/j.jhazmat.2022.129819

Associations of perfluoroalkyl substances with metabolic-associated fatty liver disease and non-alcoholic fatty liver disease: NHANES 2017–2018

Yuxiao Zhang, Min Zhang, Shanjiamei Jiang, Heng Hu, Xinzhi Wang, Fan Yu, Yue’e Huang and Yali Liang

Cancer Causes Control, 2024, 35, 1271
DOI: 10.1007/s10552-024-01865-5

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

Josephine M. Brown-Leung and Jason R. Cannon

Chem. Res. Toxicol., 2022, 35, 1312
DOI: 10.1021/acs.chemrestox.2c00072

Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review

Himal Suthar, Roselyn B. Tanghal, Lida Chatzi, Jesse A. Goodrich, Rachel Morello-Frosch and Max Aung

Curr Envir Health Rpt, 2024, 11, 404
DOI: 10.1007/s40572-024-00451-w

Behavioral outcomes and exposure to perfluoroalkyl substances among children aged 6–13 years: The TEDDY child study

Paolo Girardi, Alice Lupo, Libera Ylenia Mastromatteo and Sara Scrimin

Environmental Research, 2023, 231, 116049
DOI: 10.1016/j.envres.2023.116049

Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life

Huai-Yu Zhuchen, Jie-Yu Wang, Xiao-Shan Liu and Yan-Wei Shi

Toxics, 2023, 11, 571
DOI: 10.3390/toxics11070571

A review of the occurrence and distribution of Per- and polyfluoroalkyl substances (PFAS) in human organs and fetal tissues

Jose L. Domingo

Environmental Research, 2025, 272, 121181
DOI: 10.1016/j.envres.2025.121181

Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers

Ruo-yu Li, Jun Wu, Wan Xiao, Yang Zhou, Ke Liang, Jia-ying Bao, Zhi-yuan Yao, Chao Zhang and Yu-hui Wan

Ecotoxicology and Environmental Safety, 2025, 302, 118548
DOI: 10.1016/j.ecoenv.2025.118548

Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice: Insights into epigenetic mechanisms and pathway-specific responses

Mia Sands, Xing Zhang, Arnon gal, Mary Laws, Michael Spinella, Zeynep-Madak Erdogan and Joseph Irudayaraj

Environment International, 2024, 185, 108556
DOI: 10.1016/j.envint.2024.108556

Number of Carbons Is a Critical Parameter for Accumulation of Per- and Polyfluoroalkyl Substances in the Human Brain

Marina Suzuki, Sandra Nilsson, Claire E. Shepherd, Ian Zammit, Eurwin Suryana, Nicole Mueller, Glenda Halliday, Xianyu Wang, Christos Symeonides, Sarah Dunlop and Jochen F. Mueller

Environ. Sci. Technol., 2025, 59, 3366
DOI: 10.1021/acs.est.4c09458

Toxicokinetic Profiling and Developmental Toxicity of Long-Chain Per- and Polyfluoroalkyl Substances in Zebrafish

Paul G. Kraus, Youn-Jeong Choi, Linda S. Lee and Jennifer L. Freeman

Environ. Sci. Technol., 2025, 59, 25623
DOI: 10.1021/acs.est.5c10194

Species Difference? Bovine, Trout, and Human Plasma Protein Binding of Per- and Polyfluoroalkyl Substances

Weiping Qin, Beate I. Escher, Julia Huchthausen, Qiuguo Fu and Luise Henneberger

Environ. Sci. Technol., 2024, 58, 9954
DOI: 10.1021/acs.est.3c10824

Concentrations of 45 Per- and Polyfluoroalkyl Substances in North American River Otters (Lontra canadensis) from West Virginia, USA

Zhong-Min Li, Anna Roos, Thomas L. Serfass, Conner Lee and Kurunthachalam Kannan

Environ. Sci. Technol., 2024, 58, 2089
DOI: 10.1021/acs.est.3c09467

Impact of per- and polyfluoroalkyl substances on diabetic kidney disease

Siyuan Song, Liji Huang, Xiqiao Zhou, Yuan Han and Jiangyi Yu

Front. Endocrinol., 2025, 16
DOI: 10.3389/fendo.2025.1594897

Early F-53B Exposure Induces Autism Spectrum Disorder-like Hypomyelination and Oligodendrocytes-Derived Exosomal Protein-Dependent Axonal Energy Imbalance

Shen-Pan Li, Jing Zhang, Wen-Hui Zhao, Su-Qin Tan, Hua-Lian Chen, Xing-Yu Chen, Qiong Zhang, Dan Cai, Guang-Hui Dong and Xiao-Wen Zeng

Environ. Sci. Technol., 2026, 60, 5363
DOI: 10.1021/acs.est.5c16736

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

Lisa Truong, Yvonne Rericha, Preethi Thunga, Skylar Marvel, Dylan Wallis, Michael T. Simonich, Jennifer A. Field, Dunping Cao, David M. Reif and Robyn L. Tanguay

Journal of Hazardous Materials, 2022, 431, 128615
DOI: 10.1016/j.jhazmat.2022.128615

Prenatal perfluoroalkyl substances exposure and neurodevelopment in toddlers: Findings from SMBCS

Boya Zhang, Zheng Wang, Jiming Zhang, Yiming Dai, Chao Feng, Yuanjie Lin, Lei Zhang, Jianqiu Guo, Xiaojuan Qi, Xiuli Chang, Dasheng Lu, Chunhua Wu and Zhijun Zhou

Chemosphere, 2023, 313, 137587
DOI: 10.1016/j.chemosphere.2022.137587

A comparative review of the toxicity mechanisms of perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS) in fish

Mark Kreychman, Emma Ivantsova, Austin Lu, Joseph H. Bisesi and Christopher J. Martyniuk

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2024, 279, 109874
DOI: 10.1016/j.cbpc.2024.109874

Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications

Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli and Francesco Dondero

JoX, 2024, 14, 1771
DOI: 10.3390/jox14040094