Synthesis of dihydropyrimidinones via urea-based multicomponent reactions

Anirban Mandal, Prasanjit Ghosh and Sajal Das

Org. Biomol. Chem., 2025, 23, 5064
DOI: 10.1039/D5OB00180C

Clay based heterogeneous catalysts for carbon–nitrogen bond formation: a review

P. Vinoth Kumar and G. Madhumitha

RSC Adv., 2024, 14, 4810
DOI: 10.1039/D3RA06358E

Synthesis of a series of Cd(ii) furan-2-thiocarobxylates: unprecedented coordination geometry of a Cd(ii) complex exhibiting catalytic efficiency for the synthesis of 3,4-dihydropyrimidine-2(1H)-one derivatives

Krishna Kumar, Akash Shrivastav, Sakshi, Angshuman Roy Choudhury and Subrato Bhattacharya

New J. Chem., 2024, 48, 12654
DOI: 10.1039/D3NJ04083F

Application of magnetic materials bearing Brønsted acid sites – based on the modification of amorphous carbon with ionic liquids as catalysts for synthesis of dihydropyrimidinone derivatives via the Biginelli reaction

Thai-Phien Huynh Dang, Thach Ngoc Pham, Phuong Hoang Tran and Hai Truong Nguyen

Mater. Adv., 2025, 6, 3314
DOI: 10.1039/D5MA00045A

Green synthesis of new adamantane-containing dihydropyrimidine derivatives as potential anticancer agents

Adeleh Moshtaghi Zonouz, Mina Abkar Aras, Nahideh Jafari, Zahra Rezaei and Hamed Hamishehkar

RSC Adv., 2025, 15, 7949
DOI: 10.1039/D5RA00284B

Efficient Green Synthesis of Imidazo[2,1-b]thiazol-5-yl-2,4-dihydropyrano[2,3-c]pyrazole Derivatives Using HPA-Montmorillonite-KSF

Pragati Kushwaha, Ayush Bhardwaj, Rashi Rashi, Danish Khan and Maneesh Kumar Gupta

Synlett, 2025, 36, 2323
DOI: 10.1055/a-2577-2065

Green and sustainable synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones via the Biginelli reaction using L-arabinose as a renewable catalyst under solvent-free conditions

Priya C. Saroj, Sai Srinivas Ponugoti, Shivangi Sawant and Shreerang V. Joshi

Synthetic Communications, 2025, 55, 152
DOI: 10.1080/00397911.2024.2435463

Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2,3-dihydro quinazoline and dihydropyrimidinones derivatives

Nastaran Ghanbari and Hossein Ghafuri

Heliyon, 2023, 9, e20978
DOI: 10.1016/j.heliyon.2023.e20978

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari and Rambabu Gundla

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202405463

Synthesis, Spectral Characterization, and Antimicrobial Activity of Novel Biginelli-Type Compounds Containing Sulfaguanidine

M. A. Bhat, A. M. Naglah, A. A. Khan, M. A. Al-Omar, F. S. Aleanizy, E. K. Eltayb and F. Y. Alqahtani

Russ J Gen Chem, 2023, 93, 931
DOI: 10.1134/S1070363223040217

2,6‐Pyridinedicarboxylic Acid (PDCA) Catalyzed Improved Synthetic Approach for 1‐Amidoalkyl Naphthols, Dihydropyrimidin‐2(1H)‐ones and Bis‐indoles

Chinnasamy Govindhan and Panneer Selvam Nagarajan

ChemistrySelect, 2021, 6, 8716
DOI: 10.1002/slct.202102445

Osthole: A Coumarin with Dual Roles in Biology and Chemistry

Min Lv, Haixia Ding and Hui Xu

Biology, 2025, 14, 588
DOI: 10.3390/biology14060588

Medicinal perspective of a promising scaffold – dihydropyrimidinones: A review

Bhavesh H. Sarvaiya, Palak I. Vaja, Niraj A. Paghdar and Satish M. Ghelani

Journal of Heterocyclic Chem, 2024, 61, 1325
DOI: 10.1002/jhet.4855

Morpholinum Sulphate Salt Immobilized Onto Magnetic NPs Catalyzed Sonication Green Synthesis of Dihydropyrimidinones

Hourieh-Sadat Oboudatian, Mohsen Moradian and Hossein Naeimi

J Clust Sci, 2023, 34, 297
DOI: 10.1007/s10876-021-02214-1

Unprecedented one-pot synthesis of 3,4-dihydropyrimidine-2-(1 h )-ones catalyzed by hydrazine sulfate through Biginelli reaction, ADMET property, molecular docking studies and their antibacterial activity on Bacillus brevis and E. coli

Brijesh, Divya Singh, Anjana Pandey and Ashutosh Pandey

Synthetic Communications, 2024, 54, 1771
DOI: 10.1080/00397911.2024.2405931

Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives and Their Therapeutic Properties

Maria Marinescu

Molecules, 2021, 26, 6022
DOI: 10.3390/molecules26196022

Structural and electronic investigation of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs): Correlations between spectroscopic and molecular docking features upon salmon sperm DNA

Laís A. Schmoeller, Felipe Wodtke, Daniel Pietezak, Daiani C. Leite, Julio C. da Rocha, Fernando R. Xavier and Rogério A. Gariani

Journal of Molecular Structure, 2022, 1266, 133546
DOI: 10.1016/j.molstruc.2022.133546

One pot green synthesis of Biginelli reaction catalysed by bio-waste metal-free super acid lignin sulphonate

Vinayak Chaudhari, Amrut Patil, Sharad Patil, Gokul P. Borse and Vikas Patil

Materials Today: Proceedings, 2024
DOI: 10.1016/j.matpr.2024.05.022

Design, Synthesis, and Fungicidal Evaluation of Novel 1,3-Benzodioxole-Pyrimidine Derivatives as Potential Succinate Dehydrogenase Inhibitors

Yue Sun, Zihui Yang, Qingsong Liu, Xuebao Sun, Linlin Chen, Lu Sun and Wen Gu

J. Agric. Food Chem., 2022, 70, 7360
DOI: 10.1021/acs.jafc.2c00734

Sulfonated Melamine–Formaldehyde Resin as a Robust Catalyst for Biginelli Reactions: Synthesis of 3, 4-Dihydropyrimidinones

Dariush Khalili and Fatemeh Rezaei

Iran J Sci, 2025, 49, 943
DOI: 10.1007/s40995-025-01795-0

SbPh 3 : An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli Reaction

Anamika Khaskel, Santosh Kumari Bajiya, Suman Lata, Rakesh Kumar Sharma and Shatabdi Basu

Organic Preparations and Procedures International, 2023, 55, 525
DOI: 10.1080/00304948.2023.2190711

Dihydropyrimidinones as potent anticancer agents: Insight into the structure–activity relationship

Tanya Prasad, Aastha Mahapatra, Tripti Sharma, Chita R. Sahoo and Rabindra Nath Padhy

Archiv der Pharmazie, 2023, 356
DOI: 10.1002/ardp.202200664

1,3-Bis(carboxymethyl)imidazolium Chloride as a Sustainable, Recyclable, and Metal-Free Ionic Catalyst for the Biginelli Multicomponent Reaction in Neat Condition

Prabhakara Madivalappa Davanagere and Barnali Maiti

ACS Omega, 2021, 6, 26035
DOI: 10.1021/acsomega.1c02976

Sintesis Etil 4-(3,5-dimetil-4-fenoksifenil)-6-metil-2-okso-1,2,3,4-tetrahidropirimidin-5-Karboksilat dan Uji Aktivitas Sitotoksik Terhadap Sel T47D

Fariha Mufidah Maulina, Ahmad Fauzi, Muhammad Reza Ramadhan and Wafiq Kholifatul Hakimah

JPS, 2025, 716
DOI: 10.36490/journal-jps.com.v8i2.772

Wound healing properties of Biginelli scaffolds in Tilapia gill cell line: an in vitro analysis and computational approaches

Noorudeen Paringamalai, Syed Tajudeen Syed Ameen, Abdul Matheen Ibrahim, Gani Taju, Seepoo Abdul Majeed, Azeez Sait Sahul Hameed, Sivaraj Mithra, Predhanekar Mohamed Imran and Attar Kubaib

In Vitro Cell.Dev.Biol.-Animal, 2025
DOI: 10.1007/s11626-025-01062-x

Ficus benghalensisleaf extract in biosynthesis of Fe3O4for Fe3O4@Ag‐S‐CH2‐COOH: A novel catalyst for synthesis of new 3,4‐dihydropyrimidin‐2(1H)‐ones and their anticancer evaluation

Rutikesh Gurav, Akshay Gurav, Sunita Salunkhe‐Gawali, Sushilkumar Jadhav, Prafulla Choudhari, Sandeep Sankpal and Shankar Hangirgekar

Applied Organom Chemis, 2022, 36
DOI: 10.1002/aoc.6547

Agar Supported NiO NPs: A Sustainable Approach for synthesis of 3,4‑dihydropyrimidin‑2 (1H)‑Ones in Aqueous Hydrotropic Media

Suraj R. Attar, Aboli C. Sapkal, Nilam S. Dhane and Santosh B. Kamble

Catal Lett, 2024, 154, 1160
DOI: 10.1007/s10562-023-04375-2

Osthole: Synthesis, Structural Modifications, and Biological Properties

Zili Ren, Min Lv and Hui Xu

MRMC, 2022, 22, 2124
DOI: 10.2174/1389557522666220214101231

Chlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action

Emilija Milović, Ivana Z. Matić, Nina Petrović, Ivana Pašić, Tatjana Stanojković, Miloš R. Petrović, Goran A. Bogdanović, Ferda Ari and Nenad Janković

Bioorganic Chemistry, 2024, 153, 107907
DOI: 10.1016/j.bioorg.2024.107907

An effective, recyclable, bi-functionalized ionic liquid catalyzed solvent, metal, base free one-pot multicomponent reaction

Karthikeyan Parasuraman, Sakthinarayanan Jayaraman, Uthayanila Selvarasu, Venkatesan Kasi and Ramasamy ShanmugaPriya

Monatsh Chem, 2025, 156, 329
DOI: 10.1007/s00706-025-03297-6

Heterocyclic Scaffolds Bearing –N=N- Moiety: Recent Advances in the Synthesis of Heterocyclic Azo-Dispersive Dyes

Leila Zare Fekri, Mohaddeseh Kadivar-Kalmarzi and Rajender S. Varma

Polycyclic Aromatic Compounds, 2025, 45, 926
DOI: 10.1080/10406638.2024.2426631