Constructing a green oleaginous yeast cell factory for sustainable production of the plant-derived diterpenoid sclareol

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Green Chem., 2024, 26, 5202
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Reprogramming the metabolism of oleaginous yeast for sustainably biosynthesizing the anticarcinogen precursor germacrene A

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Green Chem., 2023, 25, 7988
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Construction and optimization of efficient glucose–xylose co-fermenting yeast Yarrowia lipolytica for green and sustainable succinic acid production from lignocellulosic biomass

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Green Chem., 2025, 27, 450
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Production of plant volatile terpenoids (rose oil) by yeast cell factories

Rongsheng Li, Kou Wang, Dong Wang, Liping Xu, Yusong Shi, Zhubo Dai and Xueli Zhang

Green Chem., 2021, 23, 5088
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The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics

Rachel S. Heath, Rebecca E. Ruscoe and Nicholas J. Turner

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Biosynthesis of α-bisabolene from low-cost renewable feedstocks by peroxisome engineering and systems metabolic engineering of the yeast Yarrowia lipolytica

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Green Chem., 2023, 25, 8145
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Disease resistance conferred by components of essential chrysanthemum oil and the epigenetic regulation of OsTPS1

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Sci. China Life Sci., 2023, 66, 1108
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Advances in Metabolic Engineering Paving the Way for the Efficient Biosynthesis of Terpenes in Yeasts

Wenjuan Li, Liuwei Cui, Jie Mai, Tian-Qiong Shi, Lu Lin, Zhi-Gang Zhang, Rodrigo Ledesma-Amaro, Weiliang Dong and Xiao-Jun Ji

J. Agric. Food Chem., 2022, 70, 9246
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Editorial: Exploring the insect microbiome: The potential future role in biotechnology industry

Yongjun Wei and Hongjie Li

Front. Microbiol., 2022, 13
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Construction and Optimization of Nonclassical Isoprenoid Biosynthetic Pathways in Yeast Peroxisomes for (+)-Valencene Production

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J. Agric. Food Chem., 2023, 71, 11124
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Reconstructing Candida glycerinogenes Metabolism to Efficiently Synthesize (−)-α-Bisabolol

Xueqing Du, Hong Zong, Xinyao Lu and Bin Zhuge

J. Agric. Food Chem., 2025, 73, 8990
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Engineering of Yarrowia lipolytica for terpenoid production

Jonathan Asmund Arnesen and Irina Borodina

Metabolic Engineering Communications, 2022, 15, e00213
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Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

Hui Jiang and Xi Wang

Biotechnology Advances, 2023, 65, 108151
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Release Control of Biologically Active Substances from Simulation Model of Silicone Liners

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Advanced Strategies for the Synthesis of Terpenoids in Yarrowia lipolytica

Zi-Jia Li, Yu-Zhou Wang, Ling-Ru Wang, Tian-Qiong Shi, Xiao-Man Sun and He Huang

J. Agric. Food Chem., 2021, 69, 2367
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Multiple Strategies Enhance 7-Dehydrocholesterol Production from Kitchen Waste by Engineered Yarrowia lipolytica

Tianyu Dong, Xiao Zhou, Zheng-Jie Hou, Yujie Shu, Mingdong Yao, Zhi-Hua Liu, Jing-Sheng Cheng, Wenhai Xiao and Ying Wang

J. Agric. Food Chem., 2025, 73, 693
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An updated comprehensive review of the therapeutic properties of Chamomile ( Matricaria chamomilla L.)

Wasim Akram, Sakeel Ahmed, Mohd Rihan, Swamita Arora, Mohammad Khalid, Sameer Ahmad, Faraz Ahmad, Shafiul Haque and Rahul Vashishth

International Journal of Food Properties, 2024, 27, 133
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Combination of microbial and chemical synthesis for the sustainable production of β‐elemene, a promising plant‐extracted anticancer compound

Wenjuan Li, Jie Mai, Lu Lin, Zhi‐Gang Zhang, Rodrigo Ledesma‐Amaro, Weiliang Dong and Xiao‐Jun Ji

Biotech & Bioengineering, 2023, 120, 3612
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Chamomile waste: A comprehensive insight on phytochemical and safety profile, extraction techniques and potential application

Nela Drača, Krunoslav Aladić, Marija Banožić, Drago Šubarić, Stela Jokić and Ivana Nemet

Biocatalysis and Agricultural Biotechnology, 2025, 63, 103468
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YALIcloneNHEJ: An Efficient Modular Cloning Toolkit for NHEJ Integration of Multigene Pathway and Terpenoid Production in Yarrowia lipolytica

Ya-Wen Li, Cai-Ling Yang, Qi Shen, Qian-Qian Peng, Qi Guo, Zhi-Kui Nie, Xiao-Man Sun, Tian-Qiong Shi, Xiao-Jun Ji and He Huang

Front. Bioeng. Biotechnol., 2022, 9
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Progress in the Metabolic Engineering of Yarrowia lipolytica for the Synthesis of Terpenes

Shun-Cheng Liu, Longxing Xu, Yuejia Sun, Lijie Yuan, Hong Xu, Xiaoming Song and Liangdan Sun

BioDesign Research, 2024, 6, 0051
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Reprograming the Carbon Metabolism of Yeast for Hyperproducing Mevalonate, a Building Precursor of the Terpenoid Backbone

Ge Zhang, Yurui Ma, Meina Huang, Kaizhi Jia, Ting Ma, Zongjie Dai and Qinhong Wang

J. Agric. Food Chem., 2025, 73, 606
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Identification and characterization of fatty acid desaturases in Schizochytrium sp. HX-308

Yu-Lei Jia, Yu-Zhou Wang, Fang-Tong Nong, Wang Ma, Peng-Wei Huang and Xiao-Man Sun

Algal Research, 2022, 67, 102861
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Engineering Yarrowia lipolytica to produce fuels and chemicals from xylose: A review

Tao Sun, Yizi Yu, Kaifeng Wang, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

Bioresource Technology, 2021, 337, 125484
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Engineering Plant Sesquiterpene Synthesis into Yeasts: A Review

Jie Mai, Wenjuan Li, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

J. Agric. Food Chem., 2021, 69, 9498
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Mining novel gene targets for improving tolerance to furfural and acetic acid in Yarrowia lipolytica using whole-genome CRISPRi library

Lixia Fang, Yaru Chen, Qianxi He, Luxin Wang, Qiyang Duan, Congcong Huang, Hao Song and Yingxiu Cao

Bioresource Technology, 2024, 403, 130764
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Engineering Saccharomyces cerevisiae for enhanced (–)-α-bisabolol production

Yinkun Jiang, Lu Xia, Song Gao, Ning Li, Shiqin Yu and Jingwen Zhou

Synthetic and Systems Biotechnology, 2023, 8, 187
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Genetic engineering of yeast, filamentous fungi and bacteria for terpene production and applications in food industry

Zijian Liang, Hang Zhi, Zhongxiang Fang and Pangzhen Zhang

Food Research International, 2021, 147, 110487
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Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi and Jin Hou

Biotechnol Biofuels, 2022, 15
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Advances in synthesizing plant-derived isoflavones and their precursors with multiple pharmacological activities using engineered yeasts

Wenhui Niu, Jingxian Zhang, Lingbo Qu, Xiao-Jun Ji and Yongjun Wei

Microb Cell Fact, 2025, 24
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Metabolic engineering of the oleaginous yeast Yarrowia lipolytica PO1f for production of erythritol from glycerol

Sujit Sadashiv Jagtap, Ashwini Ashok Bedekar, Vijay Singh, Yong-Su Jin and Christopher V. Rao

Biotechnol Biofuels, 2021, 14
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Engineering yeast for high-level production of β-farnesene from sole methanol

Jingjing Li, Jiaoqi Gao, Min Ye, Peng Cai, Wei Yu, Xiaoxin Zhai and Yongjin J. Zhou

Metabolic Engineering, 2024, 85, 194
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Engineering Yarrowia lipolytica for Efficient Synthesis of Geranylgeraniol

Kaifeng Wang, Mingxue Yin, Mei-Li Sun, Quanyu Zhao, Rodrigo Ledesma-Amaro, Xiao-Jun Ji and Lu Lin

J. Agric. Food Chem., 2024, 72, 20568
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Systematic metabolic engineering of Yarrowia lipolytica for efficient production of phytohormone abscisic acid

Mei-Li Sun, Ziyun Zou, Lu Lin, Rodrigo Ledesma-Amaro, Kaifeng Wang and Xiao-Jun Ji

Synthetic and Systems Biotechnology, 2025, 10, 165
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Combination of a Push–Pull–Block Strategy with a Heterologous Xylose Assimilation Pathway toward Lipid Overproduction from Lignocellulose in Yarrowia lipolytica

Tao Sun, Yizi Yu, Lexin Wang, Yichun Qi, Tian Xu, Zhe Wang, Lu Lin, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

ACS Synth. Biol., 2023, 12, 761
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Research advances in probiotic fermentation of Chinese herbal medicines

Xiaoling Zhang, Qin Miao, Chengxue Pan, Jia Yin, Leli Wang, Lingbo Qu, Yulong Yin and Yongjun Wei

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Production of High Levels of 3S,3′S-Astaxanthin in Yarrowia lipolytica via Iterative Metabolic Engineering

Hang-Zhi Zhu, Shan Jiang, Jun-Jie Wu, Xue-Rong Zhou, Peng-Yang Liu, Feng-Hong Huang and Xia Wan

J. Agric. Food Chem., 2022, 70, 2673
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Engineering the Lipid and Fatty Acid Metabolism in Yarrowia lipolytica for Sustainable Production of High Oleic Oils

Kaifeng Wang, Tian-Qiong Shi, Jinpeng Wang, Ping Wei, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

ACS Synth. Biol., 2022, 11, 1542
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Combining Metabolic Engineering and Lipid Droplet Storage Engineering for Improved α-Bisabolene Production in Yarrowia Lipolytica

Zhihui Lu, Yaping Wang, Zhuo Li, Yahui Zhang, Sicheng He, Ziyuan Zhang, Susanna Leong, Adison Wong, Cui-ying Zhang and Aiqun Yu

J. Agric. Food Chem., 2023, 71, 11534
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Advances in microbial bioconversion of methanol

Peng Cai, Xiaoyan Wu, Linfeng Xie, Yiwei Shen, Linhui Gao and Yongjin Zhou

Sci. Sin.-Chim, 2024, 54, 2199
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Engineering the oleaginous yeast Yarrowia lipolytica for β‐farnesene overproduction

Tianqiong Shi, Yawen Li, Li Zhu, Yangyang Tong, Junjie Yang, Yunming Fang, Meng Wang, Jieze Zhang, Yu Jiang and Sheng Yang

Biotechnology Journal, 2021, 16
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Engineering Yarrowia lipolytica to Produce Itaconic Acid From Waste Cooking Oil

Lanxin Rong, Lin Miao, Shuhui Wang, Yaping Wang, Shiqi Liu, Zhihui Lu, Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Krithi Pushpanathan, Adison Wong and Aiqun Yu

Front. Bioeng. Biotechnol., 2022, 10
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Advances in Metabolic Engineering for the Accumulation of Astaxanthin Biosynthesis

Bingxin Yu, Tianyue Ma, Maryam Nawaz, Hailong Chen and Heng Zheng

Mol Biotechnol, 2024
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Enhancing Precursor Supply and Engineering Efflux Systems to Improve Abscisic Acid Production and Secretion in Yarrowia lipolytica

Mei-Li Sun, Yun Xu, Lu Lin, Jian Gao, Rodrigo Ledesma-Amaro, Kaifeng Wang and Xiao-Jun Ji

J. Agric. Food Chem., 2025, 73, 6050
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Editorial: Engineering Yeast to Produce Plant Natural Products

Yongjun Wei, Boyang Ji, Rodrigo Ledesma-Amaro, Tao Chen and Xiao-Jun Ji

Front. Bioeng. Biotechnol., 2021, 9
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Engineering Yarrowia lipolytica to Enhance the Production of Malonic Acid via Malonyl‐CoA Pathway at High Titer

Qun Yang, Mengzhen Tian, Ping Dong, Yunying Zhao and Yu Deng

Advanced Science, 2025, 12
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Engineering the oleaginous yeast Candida tropicalis for α-humulene overproduction

Lihua Zhang, Haiquan Yang, Yuanyuan Xia, Wei Shen, Liming Liu, Qi Li and Xianzhong Chen

Biotechnol Biofuels, 2022, 15
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Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies

Tang-Lei Zhang, Hong-Wei Yu and Li-Dan Ye

ACS Synth. Biol., 2023, 12, 639
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Harnessing Yarrowia lipolytica Peroxisomes as a Subcellular Factory for α-Humulene Overproduction

Qi Guo, Tian-Qiong Shi, Qian-Qian Peng, Xiao-Man Sun, Xiao-Jun Ji and He Huang

J. Agric. Food Chem., 2021, 69, 13831
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(−)-α-Bisabolol Production in Engineered Escherichia coli Expressing a Novel (−)-α-Bisabolol Synthase from the Globe Artichoke Cynara cardunculus var. Scolymus

Hyun Seung Lim, Seong Keun Kim, Seung-Gyun Woo, Tae Hyun Kim, Soo-Jin Yeom, Wonshik Yong, Yoon-Joo Ko, Soo-Jung Kim, Seung-Goo Lee and Dae-Hee Lee

J. Agric. Food Chem., 2021, 69, 8492
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Iterative gene integration mediated by 26S rDNA and non-homologous end joining for the efficient production of lycopene in Yarrowia lipolytica

Zhen Luo, Jiang-Ting Shi, Xin-Liang Chen, Jun Chen, Feng Liu, Liu-Jing Wei and Qiang Hua

Bioresour. Bioprocess., 2023, 10
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Combining orthogonal plant and non-plant fatty acid biosynthesis pathways for efficient production of microbial oil enriched in nervonic acid in Yarrowia lipolytica

Kaifeng Wang, Lu Lin, Ping Wei, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

Bioresource Technology, 2023, 378, 129012
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Metabolic Engineering of Yarrowia lipolytica for Efficient Production of Terpenoids

Jingnan Wang, Zhixiao Lei, Weixu Ma, Wenqi Ma, Yujia Jiang, Wankui Jiang, Yidong Wan, Fengxue Xin, Wenming Zhang and Min Jiang

Ind. Eng. Chem. Res., 2024, 63, 14469
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Biotransformation of (−)-α-Bisabolol by Absidia coerulea

Jisu Park, Fubo Han and Ik-Soo Lee

Molecules, 2022, 27, 881
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Reprogramming the fatty acid metabolism of Yarrowia lipolytica to produce the customized omega-6 polyunsaturated fatty acids

Jinpeng Wang, Xiao Yu, Kaifeng Wang, Lu Lin, Hu-Hu Liu, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

Bioresource Technology, 2023, 383, 129231
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Building Yarrowia lipolytica Cell Factories for Advanced Biomanufacturing: Challenges and Solutions

Mei-Li Sun, Xiaoxia Gao, Lu Lin, Jing Yang, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

J. Agric. Food Chem., 2024, 72, 94
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Leveraging Stress Tolerance Property to Enhance Succinic Acid Production and Cell Metabolic Activity of Yarrowia lipolytica

Meng-Lin Sun, Donglai Fang, Duwen Zeng, Zhen-Zhi Wang, Cong-Cong Huang, Lin Zhang, Ya-Chao Fan, Sha Liao, Yingxiu Cao, Kai Li, Xin-Qing Zhao and Feng-Wu Bai

ACS Sustainable Chem. Eng., 2025, 13, 5210
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Engineering Yarrowia lipolytica for Sustainable Production of the Pomegranate Seed Oil-Derived Punicic Acid

Kaifeng Wang, Yueyue Zhou, Lizhen Cao, Lu Lin, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

J. Agric. Food Chem., 2024, 72, 3088
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Optimizing multicopy chromosomal integration for stable high-performing strains

Fei Du, Zijia Li, Xin Li, Duoduo Zhang, Feng Zhang, Zixu Zhang, Yingshuang Xu, Jin Tang, Yongqian Li, Xingxu Huang, Yang Gu, Xiaoman Sun and He Huang

Nat Chem Biol, 2024, 20, 1670
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Genetic Engineering of Yarrowia lipolytica for 1,8-cineole production: A sustainable approach

Krutika Bhoir, Gunjan Prakash and Annamma Odaneth

Enzyme and Microbial Technology, 2025, 189, 110659
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Elevating biotransamiantion of pineapple peel-derived furfural into furfurylamine by recombinant Escherichia coli carrying pyruvate decarboxylase and mutant ω-transaminase with low loading of amine donor

Yuting Liu, Yu-Cai He and Cuiluan Ma

Food Bioscience, 2024, 62, 105164
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Advancing Yarrowia lipolytica as a superior biomanufacturing platform by tuning gene expression using promoter engineering

Mei-Li Sun, Tian-Qiong Shi, Lu Lin, Rodrigo Ledesma-Amaro and Xiao-Jun Ji

Bioresource Technology, 2022, 347, 126717
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Dual cytoplasmic‐peroxisomal engineering for high‐yield production of sesquiterpene α‐humulene in Yarrowia lipolytica

Qi Guo, Ya‐Wen Li, Fang Yan, Ke Li, Yue‐Tong Wang, Chao Ye, Tian‐Qiong Shi and He Huang

Biotech & Bioengineering, 2022, 119, 2819
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Advances in synthetic biology tools paving the way for the biomanufacturing of unusual fatty acids using the Yarrowia lipolytica chassis

Kaifeng Wang, Tian-Qiong Shi, Lu Lin, Ping Wei, Rodrigo Ledesma-Amaro, Xiao-Jun Ji and He Huang

Biotechnology Advances, 2022, 59, 107984
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Metabolic engineering of Yarrowia lipolytica for terpenoids production: advances and perspectives

Ge Zhang, Huan Wang, Ze Zhang, Kevin J. Verstrepen, Qinhong Wang and Zongjie Dai

Critical Reviews in Biotechnology, 2021, 1
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Dynamic regulation combined with systematic metabolic engineering for high-level palmitoleic acid accumulation in oleaginous yeast

Yufan Zhou, Mei-Li Sun, Lu Lin, Rodrigo Ledesma-Amaro, Kaifeng Wang, Xiao-Jun Ji and He Huang

Metabolic Engineering, 2025, 89, 33
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