An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use

Pratibha Mistry, Elizabeth F. McInnes, Carol Beevers, Douglas Wolf, Richard A. Currie, Rejin Salimraj and Paul Parsons

Toxicology Letters, 2021, 351, 18
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Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis

Kristina Jochum, Andrea Miccoli, Cornelia Sommersdorf, Oliver Poetz, Albert Braeuning, Tewes Tralau and Philip Marx-Stoelting

Arch Toxicol, 2024, 98, 3641
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A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies

J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit and Frank D Sistare

Toxicological Sciences, 2022, 188, 4
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Structuring expert review using AOPs: Enabling robust weight-of-evidence assessments for carcinogenicity under ICH S1B(R1)

Susanne A. Stalford, Alex N. Cayley, Adrian Fowkes, Antonio Anax F. de Oliveira, Ioannis Xanthis and Christopher G. Barber

Computational Toxicology, 2024, 31, 100320
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Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens

Monika Batke, Fatemeh Moradi Afrapoli, Rupert Kellner, James F. Rathman, Chihae Yang, Mark T. D. Cronin and Sylvia E. Escher

Front. Toxicol., 2021, 3
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Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Daniel Desaulniers, Paule Vasseur, Abigail Jacobs, M. Cecilia Aguila, Norman Ertych and Miriam N. Jacobs

IJMS, 2021, 22, 10969
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An evolution of risk assessment for potential carcinogens in food: Scientific session proceedings

G. Craig Llewellyn, Marisa O. Rihner and Paul R. Hanlon

Regulatory Toxicology and Pharmacology, 2021, 126, 105047
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Review article: do stimulant laxatives damage the gut? A critical analysis of current knowledge

Peter Whorwell, Robert Lange and Carmelo Scarpignato

Therap Adv Gastroenterol, 2024, 17
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Retrospective analysis of carcinogenicity assessments within FDA-notified GRAS determinations

Khatera Rahmani, Yen-Ching Wu, Neil R. Buck, Alexandria Lau and Paul R. Hanlon

Hum Exp Toxicol, 2024, 43
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The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation

Tomoya Yamada, Samuel M. Cohen and Brian G. Lake

Critical Reviews in Toxicology, 2025, 55, 549
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Rethinking agrochemical safety assessment: A perspective

Fiona Sewell, Dick Lewis, Jyotigna Mehta, Claire Terry and Ian Kimber

Regulatory Toxicology and Pharmacology, 2021, 127, 105068
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Leveraging toxicogenomics in a weight of evidence approach to demonstrate a CAR-mediated mode of action for cyclobutrifluram-related mouse liver tumors

Fang Zhang, Caleb C Lord, Aniko Kende, David E Cowie, Liam B Doonan, Kathryn A Bailey, Elizabeth F McInnes and Angela Hofstra

Toxicological Sciences, 2025
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A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals

Mirjam Luijten, Raffaella Corvi, Jyotigna Mehta, Marco Corvaro, Nathalie Delrue, Susan Felter, Bodo Haas, Nicola J. Hewitt, Gina Hilton, Thomas Holmes, Miriam N. Jacobs, Abigail Jacobs, Franz Lamplmair, Dick Lewis, Federica Madia, Irene Manou, Stephanie Melching-Kollmuss, Frederic Schorsch, Katrin Schütte, Fiona Sewell, Christian Strupp, Jan Willem van der Laan, Douglas C. Wolf, Gerrit Wolterink, Ruud Woutersen, Zvonimir Zvonar, Harm Heusinkveld and Hedwig Braakhuis

Regulatory Toxicology and Pharmacology, 2020, 118, 104789
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Empirical comparison of genotoxic potency estimations: the in vitro DNA-damage ToxTracker endpoints versus the in vivo micronucleus assay

John W Wills, Elias Halkes-Wellstead, Huw D Summers, Paul Rees and George E Johnson

Mutagenesis, 2021, 36, 311
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Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays

Gina M. Hilton, Catherine Adcock, Gregory Akerman, James Baldassari, Michael Battalora, Warren Casey, Amy J. Clippinger, Rhian Cope, Amber Goetz, A. Wallace Hayes, Sabitha Papineni, Richard C. Peffer, Deborah Ramsingh, Brandy Williamson Riffle, Mitscheli Sanches da Rocha, Natalia Ryan, Edward Scollon, Nicolo Visconti, Douglas C. Wolf, Zhongyu Yan and Anna Lowit

Regulatory Toxicology and Pharmacology, 2022, 131, 105160
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The 2-year rodent bioassay in drug and chemical carcinogenesis testing: Sensitivity, according to the framework of carcinogenic action

Jose D. Suarez-Torres, Fausto A. Jimenez-Orozco and Carlos E. Ciangherotti

Toxicology Mechanisms and Methods, 2020, 30, 462
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Bruce Nathan Ames - Paradigm shifts inside the cancer research revolution

Carr J. Smith, Thomas A. Perfetti, Sir Colin Berry, Douglas E. Brash, James Bus, Edward Calabrese, Roger A. Clemens, John R. Jack Fowle, Helmut Greim, James T. MacGregor, Robert Maronpot, Peter Pressman, Errol Zeiger and A. Wallace Hayes

Mutation Research/Reviews in Mutation Research, 2021, 787, 108363
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Towards achieving a modern science-based paradigm for agrochemical carcinogenicity assessment

Gina M. Hilton, Raffaella Corvi, Mirjam Luijten, Jyotigna Mehta and Douglas C. Wolf

Regulatory Toxicology and Pharmacology, 2023, 137, 105301
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Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop

Susan P. Felter, Virunya S. Bhat, Philip A. Botham, David A. Bussard, Warren Casey, A. Wallace Hayes, Gina M. Hilton, Kelly A. Magurany, Ursula G. Sauer and Edward V. Ohanian

Critical Reviews in Toxicology, 2021, 51, 653
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Drug excipients, food additives, and cosmetic ingredients probably not carcinogenic to humans reveal a functional specificity for the 2‐year rodent bioassay

Jose D. Suarez‐Torres, Fausto A. Jimenez‐Orozco and Carlos E. Ciangherotti

J of Applied Toxicology, 2020, 40, 1113
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Applicability of Scrape Loading-Dye Transfer Assay for Non-Genotoxic Carcinogen Testing

Iva Sovadinová, Brad L. Upham, James E. Trosko and Pavel Babica

IJMS, 2021, 22, 8977
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Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data

Jakob Menz, Mario E. Götz, Ulrike Gündel, Rainer Gürtler, Kristin Herrmann, Stefanie Hessel-Pras, Carsten Kneuer, Franziska Kolrep, Dana Nitzsche, Ulrike Pabel, Benjamin Sachse, Sebastian Schmeisser, David M. Schumacher, Tanja Schwerdtle, Tewes Tralau, Sebastian Zellmer and Bernd Schäfer

Arch Toxicol, 2023, 97, 2303
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The GRAS provision - The FEMA GRAS program and the safety and regulation of flavors in the United States

John B. Hallagan, Richard L. Hall and Joanna Drake

Food and Chemical Toxicology, 2020, 138, 111236
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Quantification of cancer driver mutations in human breast and lung DNA using targeted, error‐corrected CarcSeq

Kelly L. Harris, Vijay Walia, Binsheng Gong, Karen L. McKim, Meagan B. Myers, Joshua Xu and Barbara L. Parsons

Environ and Mol Mutagen, 2020, 61, 872
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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

Miriam N. Jacobs, Annamaria Colacci, Raffaella Corvi, Monica Vaccari, M. Cecilia Aguila, Marco Corvaro, Nathalie Delrue, Daniel Desaulniers, Norman Ertych, Abigail Jacobs, Mirjam Luijten, Federica Madia, Akiyoshi Nishikawa, Kumiko Ogawa, Kiyomi Ohmori, Martin Paparella, Anoop Kumar Sharma and Paule Vasseur

Arch Toxicol, 2020, 94, 2899
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In silico approaches in carcinogenicity hazard assessment: case study of pregabalin, a nongenotoxic mouse carcinogen

Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley and Raymond R. Tice

Front. Toxicol., 2023, 5
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An examination of the linear no-threshold hypothesis of cancer risk assessment: Introduction to a series of reviews documenting the lack of biological plausibility of LNT

R. Golden, J. Bus and E. Calabrese

Chemico-Biological Interactions, 2019, 301, 2
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Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Tomoya Yamada, Samuel M. Cohen and Brian G. Lake

Critical Reviews in Toxicology, 2021, 51, 373
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Ethics and Controversies in Animal Subjects Research and Impact on Clinical Decision-Making

Michael Balls and Jarrod Bailey

Anesthesiology Clinics, 2024, 42, 593
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Application of transcriptomic and microRNA profiling in the evaluation of potential liver carcinogens

Vicky Nicolaidou and Costas Koufaris

Toxicol Ind Health, 2020, 36, 386
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Letter to the Editors regarding “10% body weight (gain) change as criterion for the maximum tolerated dose: A critical analysis”

Sir Colin L. Berry, Samuel M. Cohen, J. Christopher Corton, Joao Lauro Viana de Camargo, Gerhard Eisenbrand, Shoji Fukushima, Helmut Greim, Klaus Weber, Ivonne M.C.M. Rietjens and Christian Strupp

Regulatory Toxicology and Pharmacology, 2023, 139, 105362
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New approach methodologies in human regulatory toxicology – Not if, but how and when!

Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch and Tewes Tralau

Environment International, 2023, 178, 108082
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