Issue 34, 2021

CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

Abstract

CpxM(III)-catalyzed enantioselective C–H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C–H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in CpxM(III)-catalyzed enantioselective C–H functionalization reactions through migratory insertion of metal–carbenes/nitrenes by employing chiral CpxM(III) complexes or achiral CpxM(III) complexes combined with chiral carboxylic acids.

Graphical abstract: CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

Article information

Article type
Review Article
Submitted
27 lip 2021
Accepted
28 srp 2021
First published
28 srp 2021

Org. Biomol. Chem., 2021,19, 7264-7275

CpxM(III)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes

C. Pan, S. Yin, Q. Gu and S. You, Org. Biomol. Chem., 2021, 19, 7264 DOI: 10.1039/D1OB01248G

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