Issue 26, 2021

Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles

Abstract

The stereocontrolled formation of medium-sized carbocycles is a major goal in modern organic chemistry due to their widespread occurrence in natural products and pharmaceutically active ingredients. One approach consists in the use of cycloaddition reactions which notably results in high selectivities and atom-economy. To this end, cyclopropanes are ideal substrates since they can provide readily functionalized three- or five-carbon synthons. Herein we report advances made in cycloaddition reactions of cyclopropanes towards the synthesis of medium-sized carbocycles via transition metal catalysis or Lewis acid catalysis.

Graphical abstract: Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles

Article information

Article type
Review Article
Submitted
29 tra 2021
Accepted
05 lip 2021
First published
07 lip 2021

Org. Biomol. Chem., 2021,19, 5702-5724

Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles

J. Caillé and R. Robiette, Org. Biomol. Chem., 2021, 19, 5702 DOI: 10.1039/D1OB00838B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements