A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities

Sabuj Kanti Das; Snehasis Mishra; Krishnendu Manna; Utpal Kayal; Supratim Mahapatra; Krishna Das Saha; Sasanka Dalapati; G. P. Das; Amany A. Mostafa; Asim Bhaumik

doi:10.1039/C8CC07289B

A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities†

Sabuj Kanti Das,

^a Snehasis Mishra,^b Krishnendu Manna,^b Utpal Kayal,^a Supratim Mahapatra,^b Krishna Das Saha,^b Sasanka Dalapati,^c G. P. Das,^a Amany A. Mostafa^d and Asim Bhaumik

*^a

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* Corresponding authors

^a Department of Materials Science, Indian Association for the Cultivation of Science Jadavpur, Kolkata – 700 032, India
E-mail: msab@iacs.res.in

^b Cancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata – 700032, India

^c Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Howrah – 711103, India

^d Department of Ceramic, Nanomedicine & Tissue Engineering Laboratory, National Research Centre, El Bohouth St., Dokki, Cairo – 12622, Egypt

Abstract

We report a new highly crystalline 2D π-conjugated hexagonal mesoporous covalent organic framework material, TrzCOF, through the solvothermal polycondensation of 1,3,5-tri(4-formylbiphenyl) benzene [Ph₇(CHO)₃, TFBPB] with 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and it displayed excellent anticancer activity for human colorectal carcinoma HCT-116 cells.

This article is part of the themed collection: 20th Anniversary of the CRSI: Celebrating Indian Chemistry in ChemComm

Chemical Communications

A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities†

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