Issue 52, 2018

Rapid synthesis of polysubstituted phenanthridines from simple aliphatic/aromatic nitriles and iodo arenes via Pd(ii) catalyzed domino C–C/C–C/C–N bond formation

Abstract

An efficient and straightforward method has been developed for the synthesis of polysubstituted phenanthridines from simple aryl iodides and alkyl/aryl nitriles via the palladium-catalyzed nucleophilic addition of aryl iodides to nitriles followed by cascade formation of C–C and C–N bonds viz. in situ generated imine directed sequential two fold C–H activation.

Graphical abstract: Rapid synthesis of polysubstituted phenanthridines from simple aliphatic/aromatic nitriles and iodo arenes via Pd(ii) catalyzed domino C–C/C–C/C–N bond formation

Supplementary files

Article information

Article type
Communication
Submitted
03 svi 2018
Accepted
01 lip 2018
First published
05 lip 2018

Chem. Commun., 2018,54, 7207-7210

Rapid synthesis of polysubstituted phenanthridines from simple aliphatic/aromatic nitriles and iodo arenes via Pd(II) catalyzed domino C–C/C–C/C–N bond formation

Y. Jaiswal, Y. Kumar, J. Pal, R. Subramanian and A. Kumar, Chem. Commun., 2018, 54, 7207 DOI: 10.1039/C8CC03556C

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