Issue 28, 2016

Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells

Abstract

A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg2+ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhibits high selectivity and sensitivity up to 1.14 ppb. PYJO4 coated test strips can be used to detect mercury ions in contaminated water.

Graphical abstract: Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
07 lip 2016
Accepted
17 lip 2016
First published
17 lip 2016

J. Mater. Chem. B, 2016,4, 4934-4940

Pyrano[3,2-c]julolidin-2-ones: a novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells

A. K. Jha, S. Umar, R. K. Arya, D. Datta and A. Goel, J. Mater. Chem. B, 2016, 4, 4934 DOI: 10.1039/C6TB01413E

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