Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

Qinhui Wan; Xia-Die Wu; Zhong-Wei Hou; Yongmin Ma; Lei Wang

doi:10.1039/D4CC01335B

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Organophotoelectrocatalytic C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds†

Qinhui Wan,^a Xia-Die Wu,^a Zhong-Wei Hou,*^a Yongmin Ma^a and Lei Wang

*^ab

Author affiliations

* Corresponding authors

^a Advanced Research Institute and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang, P. R. China
E-mail: zhongwei.hou@tzc.edu.cn, leiwang88@hotmail.com

^b College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, Zhejiang, P. R. China

Abstract

An organophotoelectrocatalytic method for the C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds through dehydrogenation cross-coupling has been developed. The C(sp²)–H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.

This article is part of the themed collection: Electrochemically driven catalytic organic transformations

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Article information

DOI: https://doi.org/10.1039/D4CC01335B
Article type: Communication
Submitted: 23 ožu 2024
Accepted: 25 tra 2024
First published: 26 tra 2024

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Chem. Commun., 2024,60, 5502-5505

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Organophotoelectrocatalytic C(sp²)–H alkylation of heteroarenes with unactivated C(sp³)–H compounds

Q. Wan, X. Wu, Z. Hou, Y. Ma and L. Wang, Chem. Commun., 2024, 60, 5502 DOI: 10.1039/D4CC01335B

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