Issue 27, 2023

Nanozyme-based guanidinium peptides mediate surface reactive oxygen species for multidrug resistant bacterial infection management

Abstract

Nanozymes are effective novel antibacterial agents. However, they still have some shortcomings such as low catalytic efficiency, poor specificity, and non-negligible toxic side effects. Here, we synthesized iridium oxide nanozymes (IrOx NPs) by a one-pot hydrothermal method and used guanidinium peptide-betaine (SNLP/BS-12) to modify the surface of IrOx NPs (SBI NPs) to obtain a high-efficiency and low-toxicity antibacterial agent. In vitro experiments showed that SBI NPs with SNLP/BS12 could enhance IrOx NPs to target bacteria, mediate bacterial surface catalysis and reduce the cytotoxicity of IrOx NPs to mammalian cells. Importantly, SBI NPs were able to effectively alleviate MRSA acute lung infection and effectively promote diabetic wound healing. Accordingly, iridium oxide nanozymes functionalized with guanidinium peptides are expected to be an effective antibiotic candidate in the postantibiotic era.

Graphical abstract: Nanozyme-based guanidinium peptides mediate surface reactive oxygen species for multidrug resistant bacterial infection management

Supplementary files

Article information

Article type
Paper
Submitted
15 svi 2023
Accepted
31 svi 2023
First published
05 lip 2023

J. Mater. Chem. B, 2023,11, 6393-6403

Nanozyme-based guanidinium peptides mediate surface reactive oxygen species for multidrug resistant bacterial infection management

X. Zhu, Q. Sun, J. Chen, C. Liang, L. Chen, Y. Qi, H. Luo, L. Chen and J. Chen, J. Mater. Chem. B, 2023, 11, 6393 DOI: 10.1039/D3TB01104F

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