Issue 43, 2022

pH-Responsive nanomicelles for breast cancer near-infrared fluorescence imaging and chemo/photothermal therapy

Abstract

Chemotherapy, despite being the most common and effective cancer treatment, can cause several toxic adverse effects. Multimodal combined antitumor therapy, which accounts for the deficiency of monotherapy, has become an effective strategy for clinical cancer treatment. In this study, we describe the development of pH-sensitive Cy7-PEG-CA-DOX micelles with antitumor activity for controlled drug release, tumor imaging, and their synergy with photothermal therapy (PTT) and chemotherapy. The cyanine dye Cy7 was used as a near infrared (NIR) fluorophore and photosensitizer, and polyethylene glycol (PEG) served as a biocompatible carrier. The anticancer drug doxorubicin (DOX) was loaded onto PEG via aconitic anhydride bonds to increase pH sensitivity. Cy7-PEG-CA-DOX molecules initiated self-assembly to form nanomicelles (∼64.21 ± 0.49 nm) in aqueous solution. In vitro the DOX release rate reached 78% after 48 h at pH 5.5 due to the amide bond between DOX and aconitic anhydride becoming readily broken at low pH. Moreover, intracellular uptake images showed that Cy7-PEG-CA-DOX micelles effectively released DOX in 4T1 tumor cells. In vivo fluorescence imaging revealed that Cy7-PEG-CA-DOX micelles aggregated at tumor sites with optimal tumor imaging properties. More importantly, Cy7-PEG-CA-DOX micelles facilitated the favorable anti-breast cancer properties elicited by PTT and chemotherapy in vivo. This study provides a novel platform for constructing responsive multifunctional anticancer nanoparticles, which have significant potential applicability in controlled drug release and synergistic cancer therapy.

Graphical abstract: pH-Responsive nanomicelles for breast cancer near-infrared fluorescence imaging and chemo/photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
06 ruj 2022
Accepted
08 lis 2022
First published
11 lis 2022

J. Mater. Chem. C, 2022,10, 16283-16293

pH-Responsive nanomicelles for breast cancer near-infrared fluorescence imaging and chemo/photothermal therapy

J. Xu, X. Yang, X. Tang and M. Zhao, J. Mater. Chem. C, 2022, 10, 16283 DOI: 10.1039/D2TC03749A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements