Issue 8, 2022

Enantioselective catalytic Povarov reactions

Abstract

Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in the last ten years, since the first example was published in 1996. The use of chiral Lewis and Brønsted acids and dual strategies based on their combination with catalysts acting by hydrogen bond formation, as well as covalent aminocatalysis, are reviewed. More recent variations such as the nitroso Povarov reaction and interrupted Povarov reactions as a route to chiral scaffolds other than tetrahydroquinolines are also discussed.

Graphical abstract: Enantioselective catalytic Povarov reactions

Article information

Article type
Review Article
Submitted
19 stu 2021
Accepted
21 pro 2021
First published
21 pro 2021

Org. Biomol. Chem., 2022,20, 1550-1581

Enantioselective catalytic Povarov reactions

J. Clerigué, M. T. Ramos and J. C. Menéndez, Org. Biomol. Chem., 2022, 20, 1550 DOI: 10.1039/D1OB02270A

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