Issue 75, 2022

Recent advances in transition metal-mediated trifluoromethylation reactions

Abstract

Fluorine compounds are known for their abundance in more than 20% of pharmaceutical and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and pharmacokinetic properties of organofluorides. Consequently, the last decade has seen enormous growth in the incorporation of a trifluoromethyl group into organic motifs. With due significance, this review aims to provide a complete picture of the transition metal-mediated construction of C(sp3, sp2, and sp)–CF3 bonds via C–H/X bond functionalization or addition processes in both aliphatic and aromatic hydrocarbons. Diversified reagents ranging from radical and electrophilic to nucleophilic trifluoromethylating agents and their respective mechanisms have been further deliberated in this comprehensive overview. The comprehensive coverage on this topic is expected to make this review unique and beneficial for further future applications enriching the community towards further improvements in the field of trifluoromethylation reactions, in turn improving the propensity towards further development of agrochemical drugs.

Graphical abstract: Recent advances in transition metal-mediated trifluoromethylation reactions

Article information

Article type
Highlight
Submitted
21 srp 2022
Accepted
26 kol 2022
First published
26 kol 2022

Chem. Commun., 2022,58, 10442-10468

Recent advances in transition metal-mediated trifluoromethylation reactions

D. Mandal, S. Maji, T. Pal, S. K. Sinha and D. Maiti, Chem. Commun., 2022, 58, 10442 DOI: 10.1039/D2CC04082D

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