Issue 2, 2015

Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

Abstract

A novel strategy for the cross dehydrogenative coupling (CDC) of acetophenone hydrazones and aldehydes has been developed for the synthesis of highly substituted pyrazoles. This work, for the first time, uses elemental sulfur as a promoter as well as a hydrogen acceptor in effecting the Csp3–Csp2 bond formation via C–H activation.

Graphical abstract: Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

Supplementary files

Article information

Article type
Communication
Submitted
16 lis 2014
Accepted
10 stu 2014
First published
10 stu 2014

Chem. Commun., 2015,51, 366-369

Sulphur promoted C(sp3)–C(sp2) cross dehydrogenative cyclisation of acetophenone hydrazones with aldehydes: efficient synthesis of 3,4,5-trisubstituted 1H-pyrazoles

R. Vanjari, T. Guntreddi, S. Kumar and K. N. Singh, Chem. Commun., 2015, 51, 366 DOI: 10.1039/C4CC08210A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements