Issue 26, 2021

Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid)

Abstract

We report a novel approach for the modular and convergent construction of biocompatible graft copolymers starting from bacterial poly(γ-glutamic acid)(γ-PGA) and incorporating poly(lactic acid) (PLA). This synthesis strategy is controlled at different levels: (a) the choice of a suitable initiator for the ring-opening polymerization of lactide; (b) the chemical elaboration of the polylactic fragments; and (c) their convergent “grafting to” functionalization of bacterial γ-PGA propargyl ester using copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) click chemistry. The graft copolymers are characterized in terms of their thermal and macromolecular properties, their conformational preferences through molecular modelling, and their cytotoxicity.

Graphical abstract: Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid)

Supplementary files

Article information

Article type
Paper
Submitted
01 lip 2021
Accepted
08 lip 2021
First published
09 lip 2021

Polym. Chem., 2021,12, 3784-3793

Biocompatible graft copolymers from bacterial poly(γ-glutamic acid) and poly(lactic acid)

C. L. Zaccaria, V. Cedrati, A. Nitti, E. Chiesa, A. Martinez de Ilarduya, M. Garcia-Alvarez, M. Meli, G. Colombo and D. Pasini, Polym. Chem., 2021, 12, 3784 DOI: 10.1039/D1PY00737H

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