This review summarizes a decade of advances in the synthesis of alkynyl chalcogen derivatives, emphasizing sustainable catalytic methodologies, mechanistic innovations, and the expanding structural diversity of chalcogenated alkynes.
A Cu-mediated C(sp3)–C(sp3) coupling/cyclization sequences of unactivated ketones and acylhydrazones is reported for the expeditious construction of 3,4,6-trisubstituted and 3,5-disubstituted pyridazines.
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
In this review, we have showcased the diverse aspects of transition-metal catalysis, biocatalysis, and photocatalytic C(sp3)–H bond functionalization to access lactones and lactams.
We have developed a general and easily accessible alkynylthio nucleophile precursor to couple with various accessible carbon electrophiles, as an attractive route for their synthesis.