This feature article highlights the most recent advances in nanoparticle-enabled delivery of proteolysis-targeting chimeras (PROTACs) for spatiotemporally controlled protein degradation.
Novel PROTAC delivery system combining nano-delivery and prodrug strategies.
Schematic illustration of the combinational strategy of nanotechnology and PROTACs (Nano-PROTACs): the typical shortcomings of traditional PROTACs and the nanotechnology-based strategies for PROTAC drugs optimization.
Machine learning (ML) accelerates PROTAC design by optimizing linkers and protein–ligase interactions, enabling selective protein degradation for therapeutic applications, particularly targeting previously undruggable proteins.
This review proposes the concept of proteolysis-targeting drug delivery system (ProDDS), surveys the recent research in various ProDDSs, summarizes their design principles, and provides an outlook on future opportunities.