Mitigation of high-fat diet-induced hepatic steatosis by thyme (Thymus quinquecostatus Celak) polyphenol-rich extract (TPE): insights into gut microbiota modulation and bile acid metabolism

Xialu Sheng, Ping Zhan, Peng Wang, Wanying He and Honglei Tian

Food Funct., 2024, 15, 7333
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Bile acid pathways in Caprinae gut microbiota: adaptive shifts in microbial metabolism and community structure

Kai-Meng Shang, Rui Liu, Hong-Bo Ni, He Ma, Jin-Wen Su, Hai-Long Yu, Li Guo, Bei-Ni Chen, Xiao-Xuan Zhang and Xing Yang

Front. Microbiol., 2025, 16
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l‐Aspartic acid alleviates aflatoxin B1‐induced liver injury by regulating intestinal microflora homeostasis and bile acid metabolism

Dejing Kong, Ziqiang Zhang, Qingqing Zhang, Dongliu Luo, Chaoying Zhang, Zhe Zhang, Qiongxia Lv, Lan Wei and Yumei Liu

J Sci Food Agric, 2026
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Fluorogenic substrates and pre‐column derivatization for monitoring the activity of bile salt hydrolase from Clostridium perfringens

Tim Keuler, Valentina Wolf, Carina Lemke, Rabea Voget, Annett Braune and Michael Gütschow

Bioorganic Chemistry, 2023, 138, 106574
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Therapeutic Potential of Traditional Chinese Medicine Against Osteoarthritis: Targeting the Wnt Signaling Pathway

Shaozhuo Zhang, Jiaguo Zhan, Mai Li, Junyi Wang, Huiyou Chen, Yuxing Wang, Yuchen Fan, Bingqi Zhang, Xi Wang, Xizhe Zhang and Chongming Wu

Am. J. Chin. Med., 2024, 52, 2021
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Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice

Shengjie Li, Aoxiang Zhuge, Hui Chen, Shengyi Han, Jian Shen, Kaicen Wang, Jiafeng Xia, He Xia, Shiman Jiang, Youhe Wu and Lanjuan Li

Journal of Advanced Research, 2025, 69, 413
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Regulation of bile acids and their receptor FXR in metabolic diseases

Yao Li, Lulu Wang, Qing Yi, Linsong Luo and Yuxia Xiong

Front. Nutr., 2024, 11
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Role of gut microbiota and derived metabolites in cardiovascular diseases

Jiaqi Yu, Ya-nan Yang, Weiyao Chen, Jiaxin Hu, Zhechuan Jin, Chongming Wu and Yuyu Li

iScience, 2025, 28, 113247
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Taurodeoxycholic acid alleviates intestinal inflammation by modulating gut microbiota and TGR5-NF-kappaB axis in DSS-induced colitis

Jiahui Gao, Lixiang Li, Shanshan Zhang, Hongyu Zhao, Bingcheng Feng, Chang Liu, Xia Wang, Shiyang Li, Yanqing Li and Dong Zhao

International Immunopharmacology, 2026, 170, 116056
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Traditional Chinese medicines (TCMs) with varied meridians (Gui-Jing) differentially alleviate the adverse impact of Coptis chinensis on gut microbiota

Yanan Yang, Wenquan Su, Chenchen Zang, Yinfeng Tan, Yong Zhang, Zhi Zhou, Weiying Lu, Shengxian Wu, Xiaopo Zhang and Chongming Wu

Journal of Ethnopharmacology, 2023, 307, 116256
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Prevention of High-Fat-Diet-Induced Dyslipidemia byLactobacillus plantarumLP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora

Yu Wang, Xinyue Xing, Yuxuan Ma, Yuling Fan, Yue Zhang, Bo Nan, Xia Li, Yuhua Wang and Jingsheng Liu

J. Agric. Food Chem., 2023, 71, 7334
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Bile salt hydrolase: The complexity behind its mechanism in relation to lowering-cholesterol lactobacilli probiotics

Gianluigi Agolino, Alessandra Pino, Amanda Vaccalluzzo, Marianna Cristofolini, Lisa Solieri, Cinzia Caggia and Cinzia Lucia Randazzo

Journal of Functional Foods, 2024, 120, 106357
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Strain‐Level Screening of Human Gut Microbes Identifies Three Lactobacillus Strains as Next‐Generation Antidiabetic Probiotics

Yanan Yang, Mingxi Li, Fang Zhang, Jiaqi Yu, Jiale Cheng, Wenyi Xu and Chongming Wu

Food Frontiers, 2025, 6, 1041
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Ovalbumin Peptides Restore Intestinal Barrier Integrity via Gut–Liver Axis Modulation of Bile Salt Hydrolase and Bile Acids Crosstalk

Qi Yang, Jingbo Liu, Siwen Lyu, Shengrao Li, Qingwen Han, Cong Ma, Zhiyang Du and Ting Zhang

J. Agric. Food Chem., 2025, 73, 24741
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Gut–Brain Axis and Bile Acid Signaling: Linking Microbial Metabolism to Brain Function and Metabolic Regulation

Bojan Stanimirov, Maja Đanić, Nebojša Pavlović, Dragana Zaklan, Slavica Lazarević, Momir Mikov and Karmen Stankov

IJMS, 2025, 26, 12167
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Involvement of Bile Acid Metabolism and Gut Microbiota in the Amelioration of Experimental Metabolism-Associated Fatty Liver Disease by Nobiletin

Hongling Xu, Mingming Yuan, Kailin Niu, Wei Yang, Maoyuan Jiang, Lei Zhang and Jing Zhou

Molecules, 2024, 29, 976
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Coptis chinensis shows distinct effects on hyperlipidemia and gut microbiota in high-fat diet induced mice with cold or hot syndrome

Yanan Yang, Jiaguo Zhan, Jiale Cheng, Ying Cao and Chongming Wu

Chinese Herbal Medicines, 2025, 17, 529
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The Role of Traditional Chinese Medicine in the Management of Nonalcoholic Fatty Liver Disease: Targeting Gut Microbiome

Yifan Zhang, Hongkun Li, Na Jiang and Qingjing Ru

Am. J. Chin. Med., 2025, 53, 2103
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Cyanidin-3-rutinoside from Mori Fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway

Shi Zhong, Ya-Nan Yang, Jin-Xi Huo, Yu-Qing Sun, Hui Zhao, Xin-Tian Dong, Jia-Yi Feng, Jin Zhao, Chong-Ming Wu and You-Gui Li

The Journal of Nutritional Biochemistry, 2025, 137, 109834
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Rationally engineered a universal far-red fluorogenic substrate of bile salt hydrolase for functional imaging and inhibitor screening

Wenchao Chen, Xiaoting Niu, Xinyu Liang, Guanghao Zhu, Xue Zhang, Qing Gong, Cen Xie, Guangbo Ge, Ping Wang and Yuqi He

Chinese Chemical Letters, 2026, 37, 111320
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Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

Tianqi Cai, Xinhua Song, Xiaoxue Xu, Ling Dong, Shufei Liang, Meiling Xin, Yuhong Huang, Linghui Zhu, Tianxing Li, Xueke Wang, Yini Fang, Zhengbao Xu, Chao Wang, Meng Wang, Jingda Li, Yanfei Zheng, Wenlong Sun and Lingru Li

Front. Cell. Infect. Microbiol., 2024, 14
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Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Wenquan Su, Yanan Yang, Xiaohui Zhao, Jiale Cheng, Yuan Li, Shengxian Wu and Chongming Wu

Chinese Herbal Medicines, 2024, 16, 42
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High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice

Haiying Cai, Junhui Zhang, Chang Liu, Thanh Ninh Le, Yuyun Lu, Fengqin Feng and Minjie Zhao

Foods, 2024, 13, 699
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Semen Trigonellae alleviates LPS‐induced depressive behavior via enhancing the abundance of Ligilactobacillus spp.

Wenhui Chang, Jing Guo, Yanan Yang, Linen Zou, Yu Fu, Mingxi Li, Leilei Li, Chenxi Li, Xinya Wang, Xiaohui Zhao and Chongming Wu

Food Science & Nutrition, 2024, 12, 9414
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Therapeutic potential of dietary nutrients and medicinal foods against metabolic disorders: Targeting Akkermansia muciniphila

Wenyi Xu, Shaozhuo Zhang, Yanan Yang, Jiaguo Zhan, Chenchen Zang, Huifang Yu and Chongming Wu

Food Frontiers, 2024, 5, 329
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Caffeic acid combined with arabinoxylan or β-glucan attenuates diet-induced obesity in mice via modulation of gut microbiota and metabolites

Wei Fang, Mingyu Jin, Wentao Qi, Chunli Kong, Ge Song, Wenting Peng and Yong Wang

International Journal of Biological Macromolecules, 2024, 268, 131683
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Regulation of sterol metabolism by gut microbiota and its relevance to disease

Chaoyang Huang, Qingping Wu, Juan Wang, Jie Cai, Zelin Wang, Linghui You, Zhenjun Zhu and Yu Ding

Gut Microbes, 2025, 17
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Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis

Jing Chen, Lu Zhang, Yuyan Chen, Yang Yan and Cuihua Lu

Phytomedicine, 2025, 146, 157108
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Dietary Fibers and Prebiotics for Gut Microbiota Modulation in Type 2 Diabetes: Mechanisms and Therapeutic Potential

Ioan Cristian Crăciun, Dan Claudiu Măgureanu, Ioana Corina Bocsan, Anca Elena Crăciun, Anca Dana Buzoianu and Maria Adriana Neag

Diabetology, 2026, 7, 59
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Research Progress of Non-Alcoholic Fatty Liver Disease from the Perspective of Intestinal Flora

雪罗

ACM, 2025, 15, 477
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Lactobacillus helveticus-derived whey attenuated osteoporosis in ovariectomy rats

Aonan Xia, Yang Jiang, Yuan-Kun Lee, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang and Wei Chen

Food Science and Human Wellness, 2025, 14, 9250419
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Sea Cucumber Peptides Promote Testosterone Synthesis in Male Mice: Possibly via Alistipes‐Bile Acid‐FXR Signaling Pathway

Rongbo Pan, Ziying Min, Kailin Li, Fengqin Feng, Baodong Zheng and Xianliang Luo

Molecular Nutrition Food Res, 2025, 69
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Modulation of adipose tissue metabolism by microbial-derived metabolites

Wenyun Liu, Ge Yang, Pinyi Liu, Xin Jiang and Ying Xin

Front. Microbiol., 2022, 13
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Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

Hongtao Xu, Fang Fang, Kaizhang Wu, Jiangping Song, Yaqian Li, Xingyu Lu, Juncheng Liu, Liuyang Zhou, Wenqing Yu, Fei Yu and Jie Gao

Microbiome, 2023, 11
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Effects of dietary primary bile acids on the growth, intestinal morphology, gene expression, serum metabolites and intestinal microbiota in pearl gentian grouper fed a high lipid diet

Xing Ren, Xiaojie Lu, Fan Wang, Jia Xu, Yueyuan Tan and Aiping Feng

Aquaculture, 2025, 595, 741679
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The linkage of gut microbiota and the property theory of traditional Chinese medicine (TCM): Cold-natured and sweet-flavored TCMs as an example

Yanan Yang and Chongming Wu

Journal of Ethnopharmacology, 2023, 306, 116167
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Potentially probiotic NPL 1334 strain of Enterococcus durans benefits rats with diet-induced hypercholesterolemia

Hannan Rashid, Haseeb Anwar, Fakhir Mehmood Baig, Imran Mukhtar, Tariq Muhammad and Arsalan Zaidi

BMC Biotechnol, 2025, 25
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Calycosin improves atherosclerosis by reshaping the interaction between the gut microbiome and bile acid metabolism

Jiaqi Fu, Donghua Yu, Yuqin Liang, Xin Gao, Yunhe Shi, Yu Wang, Pingping Chen, Fang Lu and Shumin Liu

Food Science and Human Wellness, 2025, 14, 9250085
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A comparison of effects of glycocholic acid, taurocholic acid, and cholic acid on liver health in pearl gentian grouper (Epinephelus fuscoguttatus♂ × E. lanceolatus♀) fed a high-lipid diet

Jia Xu, Fajun Jiang, Yichao Li, Ermeng Yu, Shiwei Xie, Junxiang Lai and Fan Wang

Aquaculture Reports, 2025, 45, 103185
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Genomic safety assessment and metabolic modulation by Enterococcus faecium 140,623, a probiotic strain from lactasin tablets: implications for obesity management

Yongqi Gan, Cheng Liu, Xiaorui Zheng, Jun Nong, Lanyan Fan, Peng Xie, Yang Li, Bin Zhu, Ling Ning and Zan Zhang

World J Microbiol Biotechnol, 2026, 42
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Melatonin improves cholestatic liver disease via the gut‐liver axis

Xianjiao Liu, Jinyan Li, Mengdie Shi, Jun Fu, Yubo Wang, Weili Kang, Jinyan Liu, Fenxia Zhu, Kehe Huang, Xingxiang Chen and Yunhuan Liu

Journal of Pineal Research, 2024, 76
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Christensenella minuta interacts with multiple gut bacteria

Chang Xu, He Jiang, Li-Juan Feng, Min-Zhi Jiang, Yu-Lin Wang and Shuang-Jiang Liu

Front. Microbiol., 2024, 15
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Novel anti-obesity mechanisms of Pleurotus eryngii: Based on the regulatory effects of potential key gut microbiota and associated metabolites

Yaning Duan, Yunyan Yu, Hongshan Pan, Ruotong Bao, Ran Zhang, Qiuhui Hu and Gaoxing Ma

Food Bioscience, 2025, 74, 107874
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Dissection of gut microbiota and metabolites reveals the hypolipidemic effect of green mulberry leaf tea / black mulberry leaf tea in mice

Shi Zhong, Yanan Yang, Jinxi Huo, Yuqing Sun, Ning Ren, Qinhua Lu, Da Li, Pengfei Zhan, Weijie Wu, Huizhi Chen, Ben Niu, Meiliang Pan, Huanyan Ma, Qinqiao Liu, Qingsheng Li, Chongming Wu and Yougui Li

Journal of Functional Foods, 2023, 111, 105906
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Gut microbiota and hypertension: association, mechanisms and treatment

Zhihua Yang, Qingchun Wang, Yangxi Liu, Lin Wang, Zhao Ge, Zhenzhen Li, Shaoling Feng and Chongming Wu

Clinical and Experimental Hypertension, 2023, 45
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Dietary high lipid and high plant-protein affected growth performance, liver health, bile acid metabolism and gut microbiota in groupers

Jia Xu, Fan Wang, Chaoqun Hu, Junxiang Lai, Shiwei Xie, Kefu Yu and Fajun Jiang

Animal Nutrition, 2024, 19, 370
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