Lin-Yu Lu, Xiao-Xiao Sun, Hongwei Zhang, Quan-Xin Li, Jianzheng Gao, Huabin Zhang, Jingbin Zeng, Yuan-Qing Xu, Shengnan Jin, HuiJuan Wang, Shao-Fei Ni and Zhong-Yan Cao

ACS Catal., 2026, 16, 806
DOI: 10.1021/acscatal.5c07781

Enantioselective Intermolecular Radical Amidation and Amination of Benzylic C−H Bonds via Dual Copper and Photocatalysis

Xuemeng Chen, Zhong Lian and Søren Kramer

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202217638

Metal-Bound Heteroatom Radicals: Advancing Site-Selective C–H Functionalization

Jiayuan Li, Tobias Blockhaus and Guosheng Liu

J. Am. Chem. Soc., 2025, 147, 22269
DOI: 10.1021/jacs.5c07456

Palladium‐Catalyzed C8‐Fluoroalkylation and C8‐Fluoroalkenylation of Naphthalenes by C−H Activation

Hugo Amistadi‐Revol, Julie Tremblais, Nicolas Casaretto and Sébastien Prévost

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400194

A General Photocatalytic Strategy for Nucleophilic Amination of Primary and Secondary Benzylic C–H Bonds

Madeline E. Ruos, R. Garrison Kinney, Oliver T. Ring and Abigail G. Doyle

J. Am. Chem. Soc., 2023, 145, 18487
DOI: 10.1021/jacs.3c04912

Photoinduced C(sp3)–H Functionalization of Glycine Derivatives: Preparation of Unnatural α-Amino Acids and Late-Stage Modification of Peptides

Chao Wang, Rupeng Qi, Rui Wang and Zhaoqing Xu

Acc. Chem. Res., 2023, 56, 2110
DOI: 10.1021/acs.accounts.3c00260

Electrochemical Allylic C(sp3)–H Isothiocyanation via [3,3]-Sigmatropic Rearrangement

Xuezhuang Gao, Hui He, Kaili Miao, Linbao Zhang, Shao-Fei Ni, Ming Li and Weisi Guo

Org. Lett., 2024, 26, 4554
DOI: 10.1021/acs.orglett.4c01463

Copper‐Catalyzed Regio‐ and Diastereoselective Dearomative Carbosilylation of Unactivated Arenes by Intercepting the Dienyl Radical

Jialian Zheng, Kuili Liang, Zi‐Qing Li, Zunsheng Chen, Jianzhong Lu, He Zhang, Beibei Yi, Quanzhe Li, Qiuling Yang, Jinrong Li, Zhihan Zhang, Guozhu Zhang and Rui Guo

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202523719

Enantioselective S‐Alkylation of Sulfenamides With Copper‐Catalyzed Amino‐Radical‐Transfer Deboronation

Ke Wang, Yu Qi, Menghui Ding, Qi Tang, Xiaodong Shi and Xiaohan Ye

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.6304086

Photoinduced Copper‐Catalyzed Divergent Transformations of Amides via 1,5‐Hydrogen Atom Transfer

Chunxiang Pan, Mengzhen Zhang, He Zhang, Guanghui Meng, Shuting Liu, Yan Huang, Guozhu Zhang and Rui Guo

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202402146

Photoinduced Copper‐Catalyzed Asymmetric Radical Sulfonylcyanation of Vinylarenes with Sulfonyl Cyanides

Ke Zhao, Bin Zhang, Fu‐Yuan Zhao, Wen‐Jing Xiao and Jia‐Rong Chen

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202500258

Benzoyl cyanide, a general radical acylating reagent for photoredox-catalyzed benzylic site-selective acylation reactions

Zhaodong Zhu and Jingjing Wu

Sci. China Chem., 2024, 67, 3833
DOI: 10.1007/s11426-024-2309-5

Heterocoupling Two Similar Benzyl Radicals by Dual Photoredox/Cobalt Catalysis

Wei Yang, Zhenyan Zhao, Yu Lan, Zhou Dong, Ruiying Chang, Yihang Bai, Shihan Liu, Shi‐Jun Li and Linbin Niu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202421256

Photoinduced Copper-Catalyzed Late-Stage Azidoarylation of Alkenes via Arylthianthrenium Salts

Yuan Cai, Sagnik Chatterjee and Tobias Ritter

J. Am. Chem. Soc., 2023, 145, 13542
DOI: 10.1021/jacs.3c04016

A Cut-and-Sew Strategy with Rongalite: Sulfonylmethylation Relay of Two Distinct Alkenes to Access Lactam–Chromone Hybrid Alkyl–Alkyl Sulfones

Miao Wang, Hui-Ying Ren, Shan Jiang and Bang-Tun Zhao

Org. Lett., 2025, 27, 12024
DOI: 10.1021/acs.orglett.5c03726

Cu(I)-Catalyzed Chemo- and Enantioselective Desymmetrizing C–O Bond Coupling of Acyl Radicals

Zhang-Long Yu, Yong-Feng Cheng, Ji-Ren Liu, Wu Yang, Dan-Tong Xu, Yu Tian, Jun-Qian Bian, Zhong-Liang Li, Li-Wen Fan, Cheng Luan, Ang Gao, Qiang-Shuai Gu and Xin-Yuan Liu

J. Am. Chem. Soc., 2023, 145, 6535
DOI: 10.1021/jacs.3c00671

Modern Macrolactonization Techniques

Max Van Hoof, Guillaume Force and David Lebœuf

Synthesis, 2024, 56, 714
DOI: 10.1055/a-2181-9800

A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols

Sheng Xu, Yuanyuan Ping, Yinyan Su, Haoyun Guo, Aowei Luo and Wangqing Kong

Nat Commun, 2025, 16
DOI: 10.1038/s41467-024-55744-3

Iron‐Catalyzed Trifluoromethylation of Indole‐Tethered Alkene Enables Synthesis of CF3‐Containing Spiroindolenines and Tetrahydrocarbazoles

Yilin Zhao, Tingting Hou, Liming Zhang, Xue Wang, Jingli Hou, Yangping Liu, Guifang Han and Yuguang Song

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300253

Photoinduced Copper‐Catalyzed Enantioselective Allylic C(sp3)−H Oxidation of Acyclic 1‐Aryl‐2‐alkyl Alkenes as Limiting Substrates

Xuemeng Chen, Heng‐Hui Li and Søren Kramer

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202413190

Enantioselective Intermolecular Radical Amidation and Amination of Benzylic C−H Bonds via Dual Copper and Photocatalysis

Xuemeng Chen, Zhong Lian and Søren Kramer

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202217638

Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Shuai Liu, Jun Zhou, Lu Yu, Yingle Liu, Yangen Huang, Yao Ouyang, Guo-Kai Liu, Xiu-Hua Xu and Norio Shibata

Chem. Rev., 2025, 125, 4603
DOI: 10.1021/acs.chemrev.4c00661

Room‐Temperature Direct Homolysis of Csp3─H Bond via Catalyst‐Free Photoexcitation

Qi Miao, Meng Liu, Jun Wang, Pan Wu, Changjun Liu, Jian He, Giacomo Lo Zupone and Wei Jiang

Exploration, 2025, 5
DOI: 10.1002/EXP.20240237

Unlocking the Nucleophilicity of Strong Alkyl C–H Bonds via Cu/Cr Catalysis

Pan Peng, Yifan Zhong, Cong Zhou, Yongsheng Tao, Dandan Li and Qingquan Lu

ACS Cent. Sci., 2023, 9, 756
DOI: 10.1021/acscentsci.2c01389

Copper-catalyzed asymmetric C(sp3)-H cyanoalkylation of glycine derivatives and peptides

Rupeng Qi, Qiao Chen, Liangyu Liu, Zijian Ma, Da Pan, Hongying Wang, Zhixuan Li, Chao Wang and Zhaoqing Xu

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-38871-1

Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds

Manman Wang, Wenhui Xi, Hao Wu and Dachang Bai

Chinese Journal of Organic Chemistry, 2025, 45, 516
DOI: 10.6023/cjoc202406033

Mechanistic Insights into Enantioselective C(sp3)−H Acylation to Construct α‐Amino Ketones via Photoredox and Ni(II) Dual Catalysis: A DFT Study

Ran Liu, Kang Lv and Xiaoguang Bao

Chemistry An Asian Journal, 2023, 18
DOI: 10.1002/asia.202201266

Controllable Regiodivergent Alkynylation of 1,3‐Bis(Boronic) Esters Activated by Distinct Organometallic Reagents

Ang Chen, Yang Qiao and De‐Wei Gao

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202312605

Water and Air Stable Copper(I) Complexes of Tetracationic Catenane Ligands for Oxidative C−C Cross‐Coupling

Man Pang Tang, Lihui Zhu, Yulin Deng, Yi‐Xiang Shi, Samuel Kin‐Man Lai, Xiaoyong Mo, Xin‐Yu Pang, Chunyu Liu, Wei Jiang, Edmund Chun Ming Tse and Ho Yu Au‐Yeung

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202405971

Heterobenzyl Chlorides as Linchpins for C–H Arylation via Sequential C–H Chlorination/Cross-Electrophile Coupling

Jack T. Floreancig, Marco A. Lopez, Allison R. Dick, Luana Cardinale, Nicole C. Goodwin, Darren L. Poole and Shannon S. Stahl

ACS Catal., 2026, 16, 3081
DOI: 10.1021/acscatal.5c08221

Structurally tunable aryl radicals for hydrogen atom transfer: Visible-light-promoted cyanoalkylation of silyl enol ethers enabled by organic photoredox catalysis

Ikuya Fujii, Taihei Mori and Ryo Shintani

Tetrahedron, 2026, 189, 134971
DOI: 10.1016/j.tet.2025.134971

Mechanistic Investigation into Single-Electron Oxidative Addition of Single-Atom Cu(I)-N4 Site: Revealing the Cu(I)–Cu(II)–Cu(I) Catalytic Cycle in Photochemical Hydrophosphinylation

Guanglin Wang, Yichang Liu, Xiangyu Zhang, Xupeng Zong, Xu Zhang, Kun Zheng, Dan Qu, Li An, Xiaotian Qi and Zaicheng Sun

J. Am. Chem. Soc., 2024, 146, 8668
DOI: 10.1021/jacs.4c01023

Strategies and Mechanisms of First-Row Transition Metal-Regulated Radical C–H Functionalization

Xinghua Wang, Jing He, Ya-Nan Wang, Zhenyan Zhao, Kui Jiang, Wei Yang, Tao Zhang, Shiqi Jia, Kangbao Zhong, Linbin Niu and Yu Lan

Chem. Rev., 2024, 124, 10192
DOI: 10.1021/acs.chemrev.4c00188

Enantioselective Nickel‐Catalyzed Reductive Decarboxylative C(sp3)‐C(sp2) Cross‐Coupling of Malonic Acid Derivatives†

Jia‐Bao Wang, Shuai‐Shuai Fang, Yu Shen, Xiao‐Ting Liu, Ming‐Hong Li, Jun‐Jie Ying, Wei‐Jun Kong and Ming Shang

Chin. J. Chem., 2026
DOI: 10.1002/cjoc.70510

Thermodynamic H-Abstraction Abilities of Nitrogen Centered Radical Cations as Potential Hydrogen Atom Transfer Catalysts in Y–H Bond Functionalization

Xia Zhao, Yi-Lin Hou, Bao-Chen Qian and Guang-Bin Shen

ACS Omega, 2024, 9, 26708
DOI: 10.1021/acsomega.4c04209

Radical‐Based Enantioconvergent Reductive Couplings of Racemic Allenes and Aldehydes

Haigen Shen, Ling Yang, Mingrui Xu, Zhaoxin Shi, Ke Gao, Xiaowen Xia and Zhaobin Wang

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202413198

Catalyst‐Free Visible‐Light‐Driven CH Alkylation, Arylation, and Acylation of Quinoxalin‐2(1H)‐ones

Jing Cui, Yi‐Tong Liu, Sheng‐Bo Qi, Kai‐Kai Niu, Ling‐Bao Xing and Qing‐Min Wang

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70228

Visible‐Light‐Initiated Air‐Oxygenation of Alkylarenes to Carbonyls Mediated by Carbon Tetrabromide in Water

Chunbo Bo, Min Li, Fei Chen, Jichang Liu, Bin Dai and Ning Liu

ChemSusChem, 2024, 17
DOI: 10.1002/cssc.202301015

Recent advances in copper-catalyzed multicomponent reactions with photoinduction

Liangliang Song, Lingchao Cai, Erik V. Van der Eycken and Lei Gong

Coordination Chemistry Reviews, 2025, 528, 216428
DOI: 10.1016/j.ccr.2024.216428

Heterocoupling Two Similar Benzyl Radicals by Dual Photoredox/Cobalt Catalysis

Wei Yang, Zhenyan Zhao, Yu Lan, Zhou Dong, Ruiying Chang, Yihang Bai, Shihan Liu, Shi‐Jun Li and Linbin Niu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202421256

Computational Research on Ag(I)-Catalyzed Cubane Rearrangement: Mechanism, Metal and Counteranion Effect, Ligand Engineering, and Post-Transition-State Desymmetrization

Yumiao Ma

J. Org. Chem., 2024, 89, 3430
DOI: 10.1021/acs.joc.3c02891

Catalyst‐Free Benzylic C(sp3)─H Bond Intermolecular Amination

Wen Zhang, Man Wang, Hequan Yao and Yuli He

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202503112

Beyond Mimicking Enzymes: NewTAML/Peroxide Abstracts sp3 C–H Bonds to Initiate Biotranscendent Water-Purifying Mineralization of Fluoroquinolone Antibiotics

Xiaowei Ma, Longzhu Q. Shen, Minerva G. Schafer, Karl H. G. Schulz, Roberto R. Gil, Alexander D. Ryabov and Terrence J. Collins

J. Am. Chem. Soc., 2026, 148, 292
DOI: 10.1021/jacs.5c12768

Synthesis and modification of carbohydrates using metallaphotoredox catalysis and photoexcited-state transition metal catalysis

Jing Wang, Fan Zhou, Yuping Xu and Lei Zhang

Sustainable Chemistry and Pharmacy, 2025, 43, 101855
DOI: 10.1016/j.scp.2024.101855

Diversified Synthesis of All-Carbon Quaternary gem-Difluorinated Cyclopropanes via Copper-Catalyzed Cross-Coupling

Bin Li, Jiang-Ling Shi and Ying Xia

Org. Lett., 2023, 25, 2674
DOI: 10.1021/acs.orglett.3c00751

Phosphorothiolation of Benzylic C(sp3)–H via EnT-Mediated Radical–Radical Cross-Coupling

Pengbo Zhang, Xinyi Guo, Mengke Yang, Longyu Wang and Yuzhen Gao

Org. Lett., 2026, 28, 515
DOI: 10.1021/acs.orglett.5c04989

Transition metal-catalyzed asymmetric three-component dicarbofunctionalization of unactivated alkenes

Jian Han, Rui He and Chao Wang

Chem Catalysis, 2023, 3, 100690
DOI: 10.1016/j.checat.2023.100690

Electrochemical Late-Stage Functionalization

Yulei Wang, Suman Dana, Hao Long, Yang Xu, Yanjun Li, Nikolaos Kaplaneris and Lutz Ackermann

Chem. Rev., 2023, 123, 11269
DOI: 10.1021/acs.chemrev.3c00158

Deaminative cross-coupling of amines by boryl radical β-scission

Zhenhua Zhang, Giovanni Lonardi, Thomas Sephton, Yusuf C. Guersoy, Chiara Stavagna, Giovanni V. A. Lenardon, Massimo Bietti and Daniele Leonori

Nature, 2025, 647, 913
DOI: 10.1038/s41586-025-09725-1

Formal α-Nucleophilic Addition to Electron-Deficient Alkenes by Photoredox and Copper Dual Catalysis

Yuping Xiong, Zhiyi Zhou, Yahan Zhang, Jian-Qiang Chen and Jie Wu

Org. Lett., 2025, 27, 8915
DOI: 10.1021/acs.orglett.5c02573

Four-stage oxidation model of soot based on analysis of physical and mechanical properties

Zhiyuan Shi, Xu Lyu, Yi Luo, Daigeng Wu, Wenjie Yang and Xingyu Liang

Carbon Trends, 2025, 20, 100527
DOI: 10.1016/j.cartre.2025.100527

Photoinduced Copper‐Catalyzed Enantioselective Allylic C(sp3)−H Oxidation of Acyclic 1‐Aryl‐2‐alkyl Alkenes as Limiting Substrates

Xuemeng Chen, Heng‐Hui Li and Søren Kramer

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202413190

Mechanistic Investigations of Cobalt-Catalyzed, Aminoquinoline-Directed C(sp2)–H Bond Functionalization

Lukass Lukasevics, George N. Oh, Xiqu Wang, Liene Grigorjeva and Olafs Daugulis

J. Am. Chem. Soc., 2025, 147, 2476
DOI: 10.1021/jacs.4c13086

Enantioselective Radical‐Type 1,2‐Alkoxy‐Phosphinoylation to Styrenes Catalyzed by Chiral Vanadyl Complexes

Chin‐Wei Chuang, Guan‐Ru Huang, Shiang‐Fu Hung, Chan‐Wei Hsu, Yue‐Hua Liu, Chiu‐Han Hwang and Chien‐Tien Chen

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202300654

Recent Advances in Enantioselective Radical Reactions of C(sp3)—H Bond

Tianpeng Ling, Haitao Qin and Feng Liu

Chinese Journal of Organic Chemistry, 2025, 45, 498
DOI: 10.6023/cjoc202406042

Cu/photoredox-catalyzed decarboxylative radical C(sp3)-C(sp3) cross-coupling reactions

Chao Jiang, Pinhong Chen and Guosheng Liu

Sci. China Chem., 2023, 66, 2858
DOI: 10.1007/s11426-023-1762-6

Water and Air Stable Copper(I) Complexes of Tetracationic Catenane Ligands for Oxidative C−C Cross‐Coupling

Man Pang Tang, Lihui Zhu, Yulin Deng, Yi‐Xiang Shi, Samuel Kin‐Man Lai, Xiaoyong Mo, Xin‐Yu Pang, Chunyu Liu, Wei Jiang, Edmund Chun Ming Tse and Ho Yu Au‐Yeung

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202405971

Copper-Catalyzed Enantioselective Radical Esterification of Propargylic C–H Bonds

Jiajia Xi, Xiaotao Zhu and Hongli Bao

Synthesis, 2024, 56, 1393
DOI: 10.1055/a-2240-5349

Oxoammonium-Catalyzed Ether Oxidation via Hydride Abstraction: Methodology Development and Mechanistic Investigation Using Paramagnetic Relaxation Enhancement NMR

Yukun Cheng, Jonas Rein, Nguyen Le and Song Lin

J. Am. Chem. Soc., 2024, 146, 31420
DOI: 10.1021/jacs.4c11760

Asymmetric Functionalization Harnessing Radical‐Mediated Functional‐Group Migration

Fushan Chen, Zhu Cao and Chen Zhu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202424667

Recent advances in electrochemical copper catalysis for modern organic synthesis

Yemin Kim and Won Jun Jang

Beilstein J. Org. Chem., 2025, 21, 155
DOI: 10.3762/bjoc.21.9

Catalytic Chemo‐ and Regioselective Radical Carbocyanation of 2‐Azadienes for the Synthesis of α‐Amino Nitriles

Shengzu Duan, Ya Du, Lingling Wang, Xun Tian, Yujin Zi, Hongbin Zhang, Patrick J. Walsh and Xiaodong Yang

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202300605

Copper-Catalyzed Oxidative Arylation and Hydroxylation of Indolin-2-ones for Direct Construction of Tetrasubstituted Carbon Centers

Tian-Yu Li, Lin-Lin Xu, Dan-Qing Wu, Jia-Jun Liu, Yin Yang, Zhiwei Miao and Da-Zhen Xu

J. Org. Chem., 2025, 90, 960
DOI: 10.1021/acs.joc.4c01364

(Salen)Titanium‐Catalyzed Asymmetric Hydrogen Atom Transfer for Epoxides Reduction

Zhongyun Xu, Jian Shen, Longfei Li, Wanjiao Chen, Shengxiao Li, Jie Jiang and Yong‐Qiang Zhang

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202214111

Copper‐Catalyzed Radical Enantioselective Synthesis of γ‐Butyrolactones with Two Non‐vicinal Carbon Stereocenters

Mengyu Xue, Jinfeng Cui, Xiaotao Zhu, Fei Wang, Daqi Lv, Zaicheng Nie, Yajun Li and Hongli Bao

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202304275

Mechanistic Insights into the Synergistic Effect of Palladium(0) and Copper(I) on the Selective Transformation of Isocyanate to Indole

Cai‐Yun Ding, Man Li and Rong‐Zhen Liao

Chemistry An Asian Journal, 2023, 18
DOI: 10.1002/asia.202201259

Photoredox‐Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts

Jingjing Wu, Chao Shu, Zhihang Li, Adam Noble and Varinder K. Aggarwal

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202309684

Difluoromethylated Difunctionalization of Alkenes under Visible Light

Yuping Zhu, Yan-Hua Qiu, Xiao-Kang Dai, Wenjun Luo, Xiangjun Peng, Zhengwang Chen and Daohong Yu

J. Org. Chem., 2024, 89, 2525
DOI: 10.1021/acs.joc.3c02552

The application and development of cyanating reagents in asymmetric cyanation reactions

Ruirui Hua, Chukai Shao and Fu-Xue Chen

Tetrahedron Letters, 2025, 160, 155549
DOI: 10.1016/j.tetlet.2025.155549

Highly efficient synthesis of di-substituted allenes via copper-catalyzed SN2′- substitution reaction of organotitanium reagents with propargyl bromides

Chuan Wu, Li-Rong Han, Jin-Song Hou and Qing-Han Li

Tetrahedron, 2024, 168, 134345
DOI: 10.1016/j.tet.2024.134345

Benzylic C(sp3)−H Phosphonylation via Dual Photo and Copper Catalysis

Heng‐Hui Li, Yuwen Liu and Søren Kramer

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202420613

Benzylic C–H Esterification with Limiting C–H Substrate Enabled by Photochemical Redox Buffering of the Cu Catalyst

Dung L. Golden, Chaofeng Zhang, Si-Jie Chen, Aristidis Vasilopoulos, Ilia A. Guzei and Shannon S. Stahl

J. Am. Chem. Soc., 2023, 145, 9434
DOI: 10.1021/jacs.3c01662

Additive‐Free Visible‐Light‐Initiated Three‐Component Cyanation and Azidation

Zhiwei Wang, Jindong Hao, Yufen Lv, Chengming Qu, Huilan Yue and Wei Wei

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200484

Carbon isotopic labelling of carboxylic acids enabled by organic photoredox-catalysed cyanation

Zhengbo Zhu, Xuedan Wu, Gerald Thomas Bida, Huaifu Deng, Xinrui Ma, Siran Qian, Zhanhong Wu, Zibo Li and David A. Nicewicz

Nat. Synth, 2024, 4, 97
DOI: 10.1038/s44160-024-00656-9

Copper(I)‐Catalyzed Acid‐Controlled Divergent Radical Cyclization of 1,6‐Enynes to Access 1‐Indanones and 1H‐Cyclopropa[b] Naphthalene‐2,7‐diones

Elmira Jamshidi, Saideh Rajai‐Daryasarei, Robert Stranger, Alireza Ariafard, Frank Rominger and Saeed Balalaie

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202501015

Enantiospecific 1,3-hydrogen transfer of alkenes and alkynes

Qi Liu, Wan-Yi Xu, Cen-Cen You, Rong-Gui Zhou and Ying He

Trends in Chemistry, 2024, 6, 627
DOI: 10.1016/j.trechm.2024.08.004

Decarboxylative cyanation and thiocyanation via catalytic electron donor-acceptor complex with copper catalysis

Hongping Zhao, Xiaoxiang Xi, Tianbao Wu, Zimin Chen, Minyan Wang and Weiming Yuan

Sci. China Chem., 2024, 67, 3019
DOI: 10.1007/s11426-024-2123-0

Copper-Catalyzed Selective C(sp3)–H Esterification Using Azidobenziodoxole Derivatives as the Mediator

Jinglian Nong, Tian Gui, Ying Li, Yunning Xie and Yaxin Wang

Org. Lett., 2025, 27, 9674
DOI: 10.1021/acs.orglett.5c02851

Copper-Catalyzed Asymmetric Alkynylation of sp2 Allenic C–H Bonds for the Synthesis of Skipped Diynes

Ping Zhao, Yunshun Deng, Pinhong Chen and Guosheng Liu

J. Am. Chem. Soc., 2025, 147, 46847
DOI: 10.1021/jacs.5c19257

A Transition Metal-Free System for C3-H Nitrosation of Imidazo[1,2-a]pyridine Using Sodium Nitrite at Room Temperature

Huijie Qiao, Guoqun Liu, Liwei Mi, Liting Yang, Ya Chen, Kun Zhao, Hongyi Zhou, Qiaochu Zhang, Chunxia Qin, Baiwei Ma, Dehong Yang and Haiyan Yang

HETEROCYCLES, 2022, 104, 2008
DOI: 10.3987/COM-22-14740

Copper‐Catalyzed Chemoselective Asymmetric Hydrogenation of C=O Bonds of Exocyclic α,β‐Unsaturated Pentanones

Jing Guan, Jianzhong Chen, Yicong Luo, Lisen Guo and Wanbin Zhang

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202306380

Copper-Catalyzed sp2 C–H Arylation and Alkynylation of Allenes via Hydrogen Atom Abstraction

Zhongming Cheng, Jiajun Zhang, Can Li, Xiang Li, Pinhong Chen and Guosheng Liu

J. Am. Chem. Soc., 2024, 146, 24689
DOI: 10.1021/jacs.4c09324

Enantioconvergent Chan–Lam Coupling: Synthesis of Chiral Benzylic Amides via Cu-Catalyzed Deborylative Amidation

Jonathan Vu, Graham C. Haug, Tanner J. Schubert, Joshua F. Head, Robert S. Paton and Yuyang Dong

J. Am. Chem. Soc., 2025, 147, 25527
DOI: 10.1021/jacs.5c05884

Organocatalytic C−H Functionalization of Simple Alkanes

Fen Su, Fengfei Lu, Kun Tang, Xiaokang Lv, Zhongfu Luo, Fengrui Che, Hongyan Long, Xingxing Wu and Yonggui Robin Chi

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310072

Photoredox/Copper Dual-Catalyzed Remote C(sp3)-H Acyloxylation of N-Fluorocarboxamides

Xuesong Wang, Fuqi Li, Xueli Liu, Haohai Li, Qiongjiao Yan and Wei Wang

J. Org. Chem., 2026, 91, 1431
DOI: 10.1021/acs.joc.5c02799

Tailored Pyridine Enables Diverse Electrochemical Benzylic C–H Functionalization

Tian‐Sheng Chen, Hua‐Xi Liu, Zi‐Can Wang, Jie‐Qing Liu, Na Chen and Hai‐Chao Xu

Angewandte Chemie, 2026
DOI: 10.1002/ange.9433561

Copper-catalyzed C(sp3)−H amination and etherification of unactivated hydrocarbons via photoelectrochemical pathway

Jiawen Yin, Chengcheng Shi, Ao-Men Hu, Mengqi Luo, Chao Yang, Lin Guo and Wujiong Xia

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60429-6

Synthesis of Axially Chiral Vinyl Halides via Cu(I)-Catalyzed Enantioselective Radical 1,2-Halofunctionalization of Terminal Alkynes

Jun-Bin Tang, Jun-Qian Bian, Zhihan Zhang, Yong-Feng Cheng, Li Qin, Qiang-Shuai Gu, Peiyuan Yu, Zhong-Liang Li and Xin-Yuan Liu

ACS Catal., 2025, 15, 502
DOI: 10.1021/acscatal.4c06672

Fe-Catalyzed Alkylazidation of α-Trifluoromethylalkenes: An Access to Quaternary Stereocenters Containing CF3 and N3 Groups

Shuai Liu, Lu Zhang, Liang Xu, Pin Gao, Xin-Hua Duan and Li−Na Guo

Org. Lett., 2023, 25, 1336
DOI: 10.1021/acs.orglett.3c00439

Multipurpose sulfoximine-mediated radical γ-heteroarylation of unactivated C(sp3)-H bonds

Yuqian Sun, Xinxin Wu, Zhu Cao and Chen Zhu

Sci. China Chem., 2023, 66, 1435
DOI: 10.1007/s11426-023-1557-y

Site‐Selective α─C─H Functionalization of Saturated Heterocycles via Copper‐Photoredox Catalysis

Yi Lu, Ya‐Jing Chen, Xu‐Bing Li, Xiaodong Yang, Li‐Zhu Wu and Hongbin Zhang

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202508093

Visible-Light Induced Dehydrogenative Cross-Coupling of Enamides with Hydrocarbons Enabled by Aryl Thianthrenium Salt

Jian Han, Qiu-Ru Zhang, Yi-Lin Wang, Xiao-Ya Lu, Li-Li Zeng, Yu-Qing Li and Fen-Er Chen

Org. Lett., 2026, 28, 4518
DOI: 10.1021/acs.orglett.6c00763

Catalytic Metalloradical System for Radical 1,6-C(sp3)–H Amination with Concurrent Control of Site-, Chemo-, and Enantio-selectivity

Yiling Zhu, Wan-Chen Cindy Lee and X. Peter Zhang

J. Am. Chem. Soc., 2025, 147, 15755
DOI: 10.1021/jacs.5c03259

Modular synthesis of unsaturated aza-heterocycles via copper catalyzed multicomponent cascade reaction

Siqi Wei, Guocong Zhang, Yahui Wang, Mengwei You, Yanan Wang, Liejin Zhou and Zuxiao Zhang

iScience, 2023, 26, 106137
DOI: 10.1016/j.isci.2023.106137

Cu‐Catalyzed Allylic C─H Arylation of 3‐Phospholene Oxides with Triarylboroxines

Ang Li, Guo‐Jie Wu and Fu‐She Han

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202501356

Palladium(II)-Catalyzed Remote meta-C–H Functionalization of Arenes Enabled by Multitasking Oxyamides as the Linker

Yue-Lu Zhu, Qiu-Xue Sun, Jin-Shuo Feng, You-Dong Shao and Jiao Chen

Org. Lett., 2023, 25, 4416
DOI: 10.1021/acs.orglett.3c01101

Copper-catalyzed asymmetric [4+1] annulation of yne‑allylic esters with pyrazolones

Guang Xu, Cuiju Zhu, Xiang Li, Kexin Zhu and Hao Xu

Chinese Chemical Letters, 2025, 36, 110114
DOI: 10.1016/j.cclet.2024.110114

Copper‐Catalyzed Intramolecular Radical Amination of Tertiary C(sp3)−H Bonds to Access α‐Quaternary Pyrrolidines

Ang Gao, Yang‐Qing Ren, Cheng Luan, Yu Tian, Lin Liu, Qiang‐Shuai Gu, Zhong‐Liang Li, Chang‐Jiang Yang and Xin‐Yuan Liu

Asian J Org Chem, 2023, 12
DOI: 10.1002/ajoc.202300220

Construction of Heteroleptic Copper Complexes in Perylene Diimide-Based COFs for Heterogeneous Metallaphotoredox Catalysis

Xia Wu, Jun Guo, Meng-Ying Sun, Tao Du, Debo Hao, Dongyi Liu, Deyang Wang, Songwei Wen, Jun Yin, Dan Li and Jian He

J. Am. Chem. Soc., 2026, 148, 4283
DOI: 10.1021/jacs.5c17585

Enantioselective Ni‐Catalyzed Three‐Component Dicarbofunctionalization of Alkenes

Zhan Dong, Liangliang Song and Liang‐An Chen

ChemCatChem, 2023, 15
DOI: 10.1002/cctc.202300803

Copper-catalyzed primary amination of arene C H bond with hydroxylamine derivative

Xiaobin Tan, Wenfang Xiong, Baiyao Zhu, Hongjian Liu, Wanqing Wu and Huanfeng Jiang

Tetrahedron Letters, 2023, 129, 154699
DOI: 10.1016/j.tetlet.2023.154699

Terminal C(sp 3 )–H borylation through intermolecular radical sampling

Miao Wang, Yahao Huang and Peng Hu

Science, 2024, 383, 537
DOI: 10.1126/science.adj9258

Copper‐Catalyzed Fluoroamide‐Directed Remote C(sp3)‐H Bond Functionalization Through Intramolecular Hydrogen Atom Transfer

Xin Lv, Yuhao Yang, Liejin Zhou and Xiaojun Zeng

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400027

Benzylic C−H Radical Sulfation by Persulfates

Zhen Xia, Zhongyao Ye, Ting Deng, Ze Tan, Chunlang Song and Jiakun Li

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202413847

Accessing three-dimensional molecular diversity through benzylic C–H cross-coupling

Si-Jie Chen, Cyndi Qixin He, May Kong, Jun Wang, Shishi Lin, Shane W. Krska and Shannon S. Stahl

Nat. Synth, 2023, 2, 998
DOI: 10.1038/s44160-023-00332-4

Intermolecular Enantioselective Benzylic C(sp3)−H Amination by Cationic Copper Catalysis**

Ling Dai, Ying‐Ying Chen, Li‐Jun Xiao and Qi‐Lin Zhou

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202304427

Photoinduced Copper‐Catalyzed Three‐Component Radical Carboamination of Styrene Derivatives

Xiao‐Die Huan, Juan Zhang, Wen‐Jing Xiao and Jia‐Rong Chen

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202401234

Direct and Enantioselective Acylation of Diverse C(sp3)–H Bonds with Aldehydes

Zhijun Zhou, Fen Hu, Xinjing Lin, Yuanyuan Ping and Wangqing Kong

J. Am. Chem. Soc., 2026, 148, 7113
DOI: 10.1021/jacs.5c18382

Copper‐Catalyzed Regio‐ and Diastereoselective Dearomative Carbosilylation of Unactivated Arenes by Intercepting the Dienyl Radical

Jialian Zheng, Kuili Liang, Zi‐Qing Li, Zunsheng Chen, Jianzhong Lu, He Zhang, Beibei Yi, Quanzhe Li, Qiuling Yang, Jinrong Li, Zhihan Zhang, Guozhu Zhang and Rui Guo

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202523719

Copper‐Catalyzed Trifluoromethylalkynylation via Radical‐Mediated Multicomponent Process

Mai Zhang, Jia Ni, Mengtao Ma and Binlin Zhao

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202500994

Modular synthesis of β-amino acids from alkenes, amines, and CO2 via photoredox/copper dual catalysis

Lei Song and Jie Wu

Sci. China Chem., 2024, 67, 1756
DOI: 10.1007/s11426-023-1848-9

SOMOphilic alkyne vs radical-polar crossover approaches: The full story of the azido-alkynylation of alkenes

Julien Borrel and Jerome Waser

Beilstein J. Org. Chem., 2024, 20, 701
DOI: 10.3762/bjoc.20.64

Photoinduced transition-metal-catalyzed enantioselective functionalization of non-acidic C(sp3)−H bonds

Xuemeng Chen and Søren Kramer

Chem Catalysis, 2024, 4, 100854
DOI: 10.1016/j.checat.2023.100854

Streamlined Carbonylation of Csp3–H Bonds: Divergent Synthesis of Diverse Carbonyl Compounds

Le-Cheng Wang, Hefei Yang, Qiangwei Li and Xiao-Feng Wu

ACS Catal., 2025, 15, 10039
DOI: 10.1021/acscatal.5c02925

Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes

Dan Forster, Weisi Guo, Qian Wang and Jieping Zhu

ACS Catal., 2023, 13, 7523
DOI: 10.1021/acscatal.3c01782

β-Carbon functionalization of amines via α-amino Cu-carbenes

Rui Qin, Wei-Fang Zuo, Ze-Hong Zheng, Jin Zhou, Jia-Xin Li, Gen Zhou, Hao Huang, Yan-Rong Wei, Cheng Peng, Qian-Qian Yang and Bo Han

Sci. Adv., 2026, 12
DOI: 10.1126/sciadv.aea9900

Green and sustainable site- and cross-selective C-H reductive coupling of para-quinone methides with quinoxaline-2(1H)-ones

Chuanhua Qu, Sisi Zhang, Hongbo Peng, Yan Tang, Shanshan Chen, Lin Zhu and Guiting Song

Green Synthesis and Catalysis, 2025
DOI: 10.1016/j.gresc.2025.04.005

Mechanistic Insights into Copper-Catalyzed Asymmetric Cyanation of Allylic C–H Bonds

Jiayuan Li, Tilong Yang, Pinhong Chen, Farshad Shiri, Hairong Guan, Zhenyang Lin and Guosheng Liu

J. Am. Chem. Soc., 2025, 147, 14756
DOI: 10.1021/jacs.5c03680

Copper‐Catalyzed Radical Allene C(sp2)−H Cyanation

Youhao Wei, Zheng Wang, Kaifeng Wang, Jiang‐Kai Qiu, Zhaoshan Wang, Haotian Li, Xiu Duan, Kai Guo, Xiaoguang Bao and Xinxin Wu

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202317132

Recent Advances in Theoretical Studies on Cu-Mediated Bond Formation Mechanisms Involving Radicals

Ji-Ren Liu, Guo-Xiong Xu, Li-Gao Liu, Shuo-Qing Zhang and Xin Hong

ACS Catal., 2024, 14, 2429
DOI: 10.1021/acscatal.3c06042

Copper‐Catalyzed C(sp3)−H α‐Acetylation: Generation of Quaternary Centers

Otome E. Okoromoba, Ting‐An Chen, Eun Sil Jang, Claire L. McMullin, Thomas R. Cundari and Timothy H. Warren

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202418692

Copper‐Catalyzed Asymmetric Cyanation of Propargylic Radicals Derived From Silyl‐Substituted Allenes and Alkynes

Zhongming Cheng, Guoyu Zhang, Yunshun Deng, Yiping Zhang, Xiang Li, Pinhong Chen and Guosheng Liu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505939

Asymmetric Paired Electrolysis: Enantioselective Alkylation of Sulfonylimines via C(sp3)−H Functionalization

Yongsheng Tao, Wan Ma, Rui Sun, Cheng Huang and Qingquan Lu

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202409222

Direct stereoselective C(sp3)–H alkylation of saturated heterocycles using olefins

Zhijun Zhou, Yang Ke, Rui Miao, Fen Hu, Xiaoqin Wang, Yuanyuan Ping, Sheng Xu and Wangqing Kong

Nat. Chem., 2025, 17, 344
DOI: 10.1038/s41557-025-01747-6

Enantioselective radical dearomative conjugate amination enabled by Co(II)-based metalloradical catalysis

Pan Xu, Duo-Sheng Wang, Zhenyu Zhu and X. Peter Zhang

Nat Catal, 2025, 8, 1051
DOI: 10.1038/s41929-025-01418-2

Direct a-C(sp3)-H thioetheration/selenylation of nafimidone derivatives enabled by electrocatalysis

Zhihao Wang, Jian Li, Yumiao Liu, Qing Chen, Pengfei Zhang and Jirong Wu

Molecular Catalysis, 2023, 540, 113038
DOI: 10.1016/j.mcat.2023.113038

Recent Advances in Transition Metal Catalysed Dearomatization Toward the Synthesis of Complex Cyclic Compounds

Junxiu Liang, Yanchao Wu, Xiaofeng Ma and Huijing Li

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202500003

Copper‐Catalyzed Chemoselective Asymmetric Hydrogenation of C=O Bonds of Exocyclic α,β‐Unsaturated Pentanones

Jing Guan, Jianzhong Chen, Yicong Luo, Lisen Guo and Wanbin Zhang

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202306380

tert-Butyl peroxybenzoate (TBPB)-mediated copper-catalyzed C(sp3)-H methylation of 4-thiazolidinone

Rajnikant N. Ghoghari, Anant R. Patel and Kishor H. Chikhalia

Tetrahedron, 2025, 178, 134590
DOI: 10.1016/j.tet.2025.134590

Direct Benzylic C(sp3)–O Coupling with Alcohol via Site-Selective C(sp3)–H Cleavage at Room Temperature through a Remote Directing Group-Enabled Radical Relay Strategy

Fang Wang, Jiaming Chen, Xiaoqi Jia, Dailin Zhuang, Zhenyang Wan, Lifang Ma and Ziyuan Li

J. Org. Chem., 2022, 87, 10698
DOI: 10.1021/acs.joc.2c00884

C‐Centered radical intermediates for C(sp3)‐H bonds functionalization: An emerging approach towards alkyl thiocyanates

Floris Buttard, Jordan Vigier, Hélène Lebel and Tatiana Besset

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202301205

Benzylic C−H Radical Sulfation by Persulfates

Zhen Xia, Zhongyao Ye, Ting Deng, Ze Tan, Chunlang Song and Jiakun Li

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202413847

Copper-Catalyzed Intermolecular Cross-dehydrogenative C–N Coupling at Room Temperature via Remote Activating Group Enabled Radical Relay Strategy

Xiaoqi Jia, Xiangmin Tian, Dailin Zhuang, Zhenyang Wan, Jiahao Gu and Ziyuan Li

Org. Lett., 2023, 25, 2012
DOI: 10.1021/acs.orglett.3c00267

Photoinduced copper-catalyzed C–N coupling with trifluoromethylated arenes

Jun Huang, Qi Gao, Tao Zhong, Shuai Chen, Wei Lin, Jie Han and Jin Xie

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-44097-y

Recent Advances in Iodine‐Mediated Radical Reactions

Wen Yang, Jian Guo, Samual Hee and Yu Chen

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401486

Asymmetric Paired Electrolysis: Enantioselective Alkylation of Sulfonylimines via C(sp3)−H Functionalization

Yongsheng Tao, Wan Ma, Rui Sun, Cheng Huang and Qingquan Lu

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202409222

Construction of chiral nitrogen stereocenters via enantioselective C–H activation

Zechen Wu, Dongsheng Yi, Junhao Tang, Fanyi Meng, Haining Zhu, Kevin Wu, Kaining Duanmu, Jin-Quan Yu and Yanghui Zhang

Chem, 2026, 12, 102730
DOI: 10.1016/j.chempr.2025.102730

Enhanced Efficiency of Amide‐Substituted Quinuclidine‐Boranes as Hydridic Hydrogen Atom Transfer Catalysts for Photoinduced Hydroalkylation of Unactivated Olefins†

Xiao Yang, Mengdi Ma, Meichen Xu, Yubing Pang, Haiying Zhao and Juntao Ye

Chin. J. Chem., 2024, 42, 3227
DOI: 10.1002/cjoc.202400725

Visible-Light-Catalyzed Tandem Radical Addition/1,5-Hydrogen Atom Transfer/Cyclization of 2-Alkynylarylethers with Sulfonyl Chlorides

Long Li, Jiao-Zhe Li, Yong-Bin Sun, Chun-Mei Luo, Hui Qiu, Keqi Tang, Hongxin Liu and Wen-Ting Wei

Org. Lett., 2022, 24, 4704
DOI: 10.1021/acs.orglett.2c01977

Additive-Free Copper-Catalyzed Benzylic C(sp3)–H Carbamation: Simple Preparation of Primary Benzylic Amines

William Schmidt and Abolghasem Bakhoda

Synlett, 2024, 35, 215
DOI: 10.1055/a-2170-2630

Recent Advances in Copper‐Catalyzed Functionalization of Unactivated C(sp3)−H Bonds

Neha Deshpande, Piyushkumar Satani, Akshay Bharodiya and Togati Naveen

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200532

Stereoselective Synthesis of Glycomimetics by Photocatalytic One‐Pot C(sp3)─H Acylation and Ring Contraction

Zhijun Zhou, Yuqi Ai, Sheng Xu, Xinjing Lin, Yuanyuan Ping and Wangqing Kong

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202510594

Lewis Acid-Mediated Regioselective Hydrofunctionalization of Styrenes with Isatins and Heterocycles

Shengxiang Qin, Yunshi Liao, Qiang Ni, Rihui Cao, Albert S. C. Chan and Liqin Qiu

J. Org. Chem., 2025, 90, 1016
DOI: 10.1021/acs.joc.4c02173

Recent Advances in the 3 d‐Transition‐Metal‐Catalyzed Synthesis of Isoquinolines and its Derivatives

Vipin K. Maikhuri, Manish Rawat and Diwan S. Rawat

Adv Synth Catal, 2023, 365, 4458
DOI: 10.1002/adsc.202301239

Transition Metal‐Promoted Direct CS and CSe Bond Formation from Csp3H Bonds

Douglas B. Paixão, Diego Seckler, Carla M. B. Gomes, Gul Badshah, Gabriel P. Bueno, Paulo H. Schneider, Ricardo S. Schwab and Daniel S. Rampon

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500111

Copper-Catalyzed Three-Component Sulfur-Stereogenic Sulfilimination of Conjugated and Cumulated Dienes

Hanlin Yang, Mei Yang, Jianzheng Cheng, Xiang Gao, Bin Wei, Yong Zhu, Xiao-Xi Li, Xingwei Li and Songjie Yu

ACS Catal., 2026, 16, 2777
DOI: 10.1021/acscatal.5c08488

Copper‐Catalyzed Asymmetric Cyanation of Propargylic Radicals Derived From Silyl‐Substituted Allenes and Alkynes

Zhongming Cheng, Guoyu Zhang, Yunshun Deng, Yiping Zhang, Xiang Li, Pinhong Chen and Guosheng Liu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505939

Catalytic Chemo‐ and Regioselective Radical Carbocyanation of 2‐Azadienes for the Synthesis of α‐Amino Nitriles

Shengzu Duan, Ya Du, Lingling Wang, Xun Tian, Yujin Zi, Hongbin Zhang, Patrick J. Walsh and Xiaodong Yang

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202300605

Mechanistic Insights into the Copper‐Catalyzed Cross‐Dehydrogenative Allylic Alkynylation Reaction

Paul Hünemörder, Gustavo Alvarez, Leo Gräber, Maria Logotheti, Matthias Höhne and Esteban Mejía

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202400538

Site-Selective Access to Functionalized Pyrroloquinoxalinones via H-Atom Transfer from N═Csp2–H Bonds of Quinoxalinones

Chuan-Hua Qu, Shu-Ting Li, Jian-Bo Liu, Zhong-Zhu Chen, Dian-Yong Tang, Jia-Hong Li and Gui-Ting Song

Org. Lett., 2024, 26, 9244
DOI: 10.1021/acs.orglett.4c03353

Copper-Catalyzed Cyclization and Alkene Transposition Cascade Enables a Modular Synthesis of Complex Spirocyclic Ethers

Wan-Xu Wei, Yangjin Kuang and Martin Tomanik

J. Am. Chem. Soc., 2025, 147, 1034
DOI: 10.1021/jacs.4c14418

Copper-catalyzed enantioselective synthesis of γ-butenolides via radical diversification of allenoic acid

Bingxu Han, Zaicheng Nie, Changqing Ye and Hongli Bao

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-64398-8

Enantioselective Radical‐Type 1,2‐Alkoxy‐Phosphinoylation to Styrenes Catalyzed by Chiral Vanadyl Complexes

Chin‐Wei Chuang, Guan‐Ru Huang, Shiang‐Fu Hung, Chan‐Wei Hsu, Yue‐Hua Liu, Chiu‐Han Hwang and Chien‐Tien Chen

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202300654

Versatile Copper-Catalyzed γ-C(sp3)–H Lactonization of Aliphatic Acids

Zhe Zhuang, Tao Sheng, Jennifer X. Qiao, Kap-Sun Yeung and Jin-Quan Yu

J. Am. Chem. Soc., 2024, 146, 17311
DOI: 10.1021/jacs.4c04043

Copper‐Catalyzed Radical Enantioselective Synthesis of γ‐Butyrolactones with Two Non‐vicinal Carbon Stereocenters

Mengyu Xue, Jinfeng Cui, Xiaotao Zhu, Fei Wang, Daqi Lv, Zaicheng Nie, Yajun Li and Hongli Bao

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202304275

Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C–H bonds with TON over 1000000

Zong-Rui Li, Kun Zhan, Yi-Jie Wang, Liang-Liang Wu, Guo-Lin Lu, Hao-Yang Wang, Xiao-Long Wan, Zhen-Jiang Xu, Kam-Hung Low and Chi-Ming Che

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58316-1

Carbonylation Reactions at Carbon‐Centered Radicals with an Adjacent Heteroatom

Le‐Cheng Wang and Xiao‐Feng Wu

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202413374

gem-Difluorocyclopropane Synthesis by Copper-Catalyzed C(sp³)–H Addition of 1,3-Dioxolane to Difluorocyclopropenes

Kazuhiro Morisaki, Aru Murakami and Yoshihiro Sato

Chem. Pharm. Bull., 2025, 73, 1112
DOI: 10.1248/cpb.c25-00582

Palladium(II)-Catalyzed Enantioselective Functionalization of C(sp3)—H Bonds★

Yeqiang Han and Bingfeng Shi

Acta Chimica Sinica, 2023, 81, 1522
DOI: 10.6023/A23070336

Modular Access to Nitriles From Carbonyls via Deoxygenative Transformation With Polarity Inversion

Fancong Meng, Wenhao Xu, Zhigang Wang, Yuanqiang Chen, Shuntao Xia and Tao XU

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.8039232

Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis

Angel Rentería‐Gómez, Rubén O. Torres‐Ochoa, Pierre Palamini, Raphaël Simonet‐Davin, Qian Wang, Jérôme Waser and Jieping Zhu

Helvetica Chimica Acta, 2024, 107
DOI: 10.1002/hlca.202400004

Decoupling Radical Generation and Copper Catalysis for the Remote C–H Cyanation of Unfunctionalized Sulfonamides

Jue Wang, Zhi Chen, Yali He, Chenxi Gu, Luwei Tong, Chaodong Wang and Jianjun Li

Org. Lett., 2026, 28, 1109
DOI: 10.1021/acs.orglett.5c05382

Enantioconvergent Cross‐Nucleophile Coupling: Copper‐Catalyzed Deborylative Cyanation

Jonathan Vu, Graham C. Haug, Yongxian Li, Biyu Zhao, Christopher J. Chang, Robert S. Paton and Yuyang Dong

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202408745

Photoenzymatic C(sp3)–H Functionalization of 1,3-Dicarbonyls Enables Enantioselective Hydroalkylation of Styrenes

Ermeng Wang, Qiaoyu Zhang, Qinglong Shi, Xiaoyu Wang, Ting Ma, Yixue Wu, Binju Wang and Juntao Ye

J. Am. Chem. Soc., 2025, 147, 44529
DOI: 10.1021/jacs.5c17564

Photoredox/Copper Dual-Catalyzed Benzylic C–H Esterification via Radical-Polar Crossover

Yifan Zhang, Yuxin Jiang, Yi Wang, Tianyi Sun, Yuanjie Meng, Yueyan Huang, Xiaoqing Lv, Jinlai Gao, Xiaoqin Zhang, Shilei Zhang and Shihui Liu

Org. Lett., 2022, 24, 2679
DOI: 10.1021/acs.orglett.2c00763

Free Alcohol‐Mediated Radical Alkynylation and Allylation of Unactivated C(sp3)−H Bonds

Zhu Cao, Yaohui Xu, Zhen Wu, Xinxin Wu and Chen Zhu

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403841

Copper‐Catalyzed Heterocyclic Recombination of Aziridine and Diazetidine for the Synthesis of Imidazolidine**

Daiki Higuchi, Satoshi Matsubara, Hiroki Kadowaki, Daisuke Tanaka and Kei Murakami

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301071

Defunctionalization Enabled by Intramolecular Radical Aromatic Ipso Substitution

Qijing Zhang, Tinglan Liu, Lili Wu, Cong-Ying Zhou and Chengming Wang

Org. Lett., 2024, 26, 7744
DOI: 10.1021/acs.orglett.4c02910

CuOTf(Tol)1/2-Catalyzed O-Trifluoroethylation of Alcohols with 2,2,2-Trifluorodiazoethane

Leyi Tao, Zhiyu Lei, Lianyun Zhao, Tao Ji, Yeon-Hee Lim, James Patrick Roane, Bin Hu and Xin Wen

Org. Lett., 2025, 27, 4485
DOI: 10.1021/acs.orglett.5c00942

Photoinduced Copper‐Catalyzed Asymmetric C(sp3)−H Alkynylation of Cyclic Amines by Intramolecular 1,5‐Hydrogen Atom Transfer

Rui Guo, Haijing Xiao, Sijia Li, Yixin Luo, Jiahui Bai, Mengzhen Zhang, Yinlong Guo, Xiaotian Qi and Guozhu Zhang

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202208232

Electrochemical generation and utilization of radical intermediates

Zhong-Wei Hou, Hai-Chao Xu and Lei Wang

Current Opinion in Electrochemistry, 2024, 44, 101447
DOI: 10.1016/j.coelec.2024.101447

Benzylic C(sp3)–H fluorination

Alexander P Atkins, Alice C Dean and Alastair J J Lennox

Beilstein J. Org. Chem., 2024, 20, 1527
DOI: 10.3762/bjoc.20.137

Stereoselective synthesis of (Z)-vinyl sulfonamides via kinetically controlled hydrosulfamoylation of alkynes

Haiping Lv, Xinzhou Chen, Xiaochun He, Xuemei Zhang and Zhong Lian

Sci. China Chem., 2025, 68, 6564
DOI: 10.1007/s11426-025-3051-0

Enantioconvergent Cross‐Nucleophile Coupling: Copper‐Catalyzed Deborylative Cyanation

Jonathan Vu, Graham C. Haug, Yongxian Li, Biyu Zhao, Christopher J. Chang, Robert S. Paton and Yuyang Dong

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202408745

Photoinduced Copper-Catalyzed Enantioselective Allylic C(sp3)–H Oxygenation of Acyclic Terminal Olefins Enabled by SphenBOX

Xu-Kuan Qi, Qiang Dai, Yangyi Gu, Kwan Shing Lau, Herman H. Y. Sung, Ian D. Williams, Zhenyang Lin, Chaoshen Zhang and Jianwei Sun

J. Am. Chem. Soc., 2025, 147, 20225
DOI: 10.1021/jacs.5c06136

Polar Heterobenzylic C(sp3)–H Chlorination Pathway Enabling Efficient Diversification of Aromatic Nitrogen Heterocycles

Soham Maity, Marco A. Lopez, Desiree M. Bates, Shishi Lin, Shane W. Krska and Shannon S. Stahl

J. Am. Chem. Soc., 2023, 145, 19832
DOI: 10.1021/jacs.3c05822

Copper/BINOL-Catalyzed Enantioselective C–H Functionalization toward Planar Chiral Ferrocenes Under Mild Conditions

Zhuo-Zhuo Zhang, Gang Zhou, Qiang Yue, Qi-Jun Yao and Bing-Feng Shi

ACS Catal., 2024, 14, 4030
DOI: 10.1021/acscatal.3c05955

Hydrogen atom transfer-induced selective borylation of C(sp<sup>3</sup>)–H bonds

Miao Wang, Yahao Huang and Peng Hu

Sci. Sin.-Chim, 2024, 54, 1445
DOI: 10.1360/SSC-2024-0108

Site-Selective sp2 C–H Cyanation of Allenes via Copper-Catalyzed Radical Relay

Zhongming Cheng, Tilong Yang, Can Li, Yunshun Deng, Fangjia Zhang, Pinhong Chen, Zhenyang Lin, Shengming Ma and Guosheng Liu

J. Am. Chem. Soc., 2023, 145, 25995
DOI: 10.1021/jacs.3c11368

Asymmetric Alkoxycarbonyl-Cyanation of Styrenes via Photoredox and Copper Catalysis

Zhipeng Zong, Ping Liang, Jiangkun Yao, Jian-Qiang Chen and Jie Wu

ACS Catal., 2025, 15, 13226
DOI: 10.1021/acscatal.5c04002

Copper-Catalyzed Synthesis of N-Fused Quinolines via C(sp3)–H Activation-Radical Addition–Cyclization Cascade

Yangang Wu, Wen Zhang, Shiyu Ma, Chuanjun Song and Junbiao Chang

J. Org. Chem., 2023, 88, 16978
DOI: 10.1021/acs.joc.3c01812

Electrophotocatalytic Decoupled Radical Relay Enables Highly Efficient and Enantioselective Benzylic C–H Functionalization

Wenzheng Fan, Xueyao Zhao, Yunshun Deng, Pinhong Chen, Fei Wang and Guosheng Liu

J. Am. Chem. Soc., 2022, 144, 21674
DOI: 10.1021/jacs.2c09366

C−H Bond Activation Relay (CHAR) of Proline Ester Derivatives Promoted by In Situ Triarylamine Radical Cation: Selective Synthesis of 4‐Bromopyrrole Derivatives

Han Ding, Shuwei Zhang, Zheng Sun, Qiyuan Ma, Yuemei Li, Yu Yuan and Xiaodong Jia

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203654

Oxidative Alkylarylation of N‐Aryl Bicyclobutyl Amides with C(sp3)–H Feedstocks via C(sp3)–H/C(sp2)–H Functionalization

Jing Yuan, Jiao Zhou, Peng‐Fei Xia, Yu Liu, Ke‐Wen Tang and Jian‐Hong Fan

Chin. J. Chem., 2024, 42, 3399
DOI: 10.1002/cjoc.202400748

Intramolecular Hydrogen Atom Transfer from Unactivated C(sp3)−H Bond to Alkyl Radical

Huiying Liu, Qihao Jin and Xinxin Wu

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202301280

Asymmetric Alkynylation of Tertiary Carbon‐Centered Radical via Copper‐Catalyzed Radical Relay

Dunqi Wu, Lianqian Wu, Pinhong Chen and Guosheng Liu

Chin. J. Chem., 2022, 40, 1699
DOI: 10.1002/cjoc.202200108

Metallaphotoredox Enabled Single Carbon Atom Insertion into Alkenes for Allene Synthesis

Gang Liu, Zhaoxin Shi, Chuning Guo, Danyu Gu and Zhaobin Wang

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202418746

Radical chlorination of non-resonant heterobenzylic C‒H bonds and high-throughput diversification of heterocycles

Dung L. Golden, Kaitlyn M. Flynn, Santeri Aikonen, Christopher M. Hanneman, Dipannita Kalyani, Shane W. Krska, Robert S. Paton and Shannon S. Stahl

Chem, 2024, 10, 1593
DOI: 10.1016/j.chempr.2024.04.001

Electrochemical Benzylic C–H Carboxylation

Weimei Zeng, Chengyi Peng and Youai Qiu

J. Am. Chem. Soc., 2025, 147, 13461
DOI: 10.1021/jacs.5c00259

Copper-Mediated C(sp2)–H Thiolation of Free Amines Enabled by a Transient Directing Group

Ming-Shun Mei, Dongsheng Yi, Fanyi Meng, Junhao Tang and Yanghui Zhang

Org. Lett., 2025, 27, 6284
DOI: 10.1021/acs.orglett.5c01299

Enantioselective Intermolecular C–H Functionalization of Primary Benzylic C–H Bonds Using ((Aryl)(diazo)methyl)phosphonates

Yasir Naeem, Bianca T. Matsuo and Huw M. L. Davies

ACS Catal., 2024, 14, 124
DOI: 10.1021/acscatal.3c04661

Cu(I)-catalysed chemo-, regio-, and stereoselective radical 1,2-carboalkynylation with two different terminal alkynes

Jun-Qian Bian, Li Qin, Li-Wen Fan, Jiajia Fu, Yong-Feng Cheng, Yu-Feng Zhang, Qiao Song, Peng-Fei Wang, Zhong-Liang Li, Qiang-Shuai Gu, Peng Yu, Jun-Bin Tang and Xin-Yuan Liu

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60012-z

Divergent Synthesis of Quinolones through Radical C−H Functionalization/Cyclization

Jun Xu, Wenqiang Xu, Xinhao Zhang, Jie Wu, Pengfei Zhang, Lijuan Song and Xiaogang Liu

Adv Synth Catal, 2023, 365, 1853
DOI: 10.1002/adsc.202300426

Copper-Catalyzed Three-Component Photo-ATRA-Type Reaction for Asymmetric Intermolecular C–O Coupling

Peng-Zi Wang, Yu-Jie Liang, Xue Wu, Wei Guan, Wen-Jing Xiao and Jia-Rong Chen

ACS Catal., 2022, 12, 10925
DOI: 10.1021/acscatal.2c03576

Copper-Catalyzed, Intramolecular Amination of Unactivated C(sp3)–H Bonds through Radical Relay

Liyan Zuo, Fan Yu, Shuai Zhao, Wengui Wang and Shoufeng Wang

J. Org. Chem., 2024, 89, 13077
DOI: 10.1021/acs.joc.4c01163

Metallaphotoredox-enabled aminocarboxylation of alkenes with CO2

Jun-Ping Yue, Jin-Cheng Xu, Hai-Tian Luo, Xiao-Wang Chen, He-Xin Song, Yu Deng, Lihua Yuan, Jian-Heng Ye and Da-Gang Yu

Nat Catal, 2023, 6, 959
DOI: 10.1038/s41929-023-01029-9

Radical Cascade Cyclization Involving C(sp3)—H Functionalization of Unactivated Cycloalkanes

Rongnan Yi, Jiaozhe Li, Dongkai Wang and Wenting Wei

Chinese Journal of Organic Chemistry, 2022, 42, 4111
DOI: 10.6023/cjoc202208001

Elucidating the Mechanism and Origin of Site Selectivity in the Cobalt‐Catalyzed C(sp3)H Functionalization of a Thioamide

Sai‐Bo Cao, Yan‐Kun Cui, Lujun Zhang and Yang Wang

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500742

Enantioselective Radical Trifluoromethylation of Benzylic C–H Bonds via Cooperative Photoredox and Copper Catalysis

Pin Xu, Wenzheng Fan, Pinhong Chen and Guosheng Liu

J. Am. Chem. Soc., 2022, 144, 13468
DOI: 10.1021/jacs.2c06432

Photocatalytic Cyclization Cascades by Radical Relay toward Pyrrolo[1,2-a]indoles: Synthesis, Mechanism, and Application

Chen He, Qi Wang, Xiaoyang Zhou, Lin Yi, Zhiqiang Zhang, Chun Zhang, Haijiao Xie, Qitong Huang, Guanyinsheng Qiu and Min Yang

J. Org. Chem., 2024, 89, 3509
DOI: 10.1021/acs.joc.3c02959

Catalytic Asymmetric Oxidative Coupling between C(sp3)–H Bonds and Carboxylic Acids

Xian-Ming Liu, Fu Li, Tongkun Wang, Ling Dai, Yin Yang, Neng-Quan Jiang, Li-Yuan Xue, Jing-Yuan Liu, Xiao-Song Xue, Li-Jun Xiao and Qi-Lin Zhou

J. Am. Chem. Soc., 2025, 147, 627
DOI: 10.1021/jacs.4c12544

Enantioselective Propargylic C(sp3)–H Acyloxylation Enabled by Photoexcited Copper Catalysis

Sheng Tang, Hengxin Song and Shouyun Yu

Org. Lett., 2024, 26, 10036
DOI: 10.1021/acs.orglett.4c03933

Copper/Selectfluor Co-catalyzed Ritter-Type Benzylic C—H Amination

Chunjie Qian, Boyang He, Xingyu Liu, Ping Wang, Guangchun Gao and Shihui Liu

Chinese Journal of Organic Chemistry, 2025, 45, 2181
DOI: 10.6023/cjoc202409010

Fe-Catalyzed Regioselective C(sp3)–H-Abstraction by Tertiary Cyclopropyl Radicals

Canxiang Liu, Tingting Feng, Xinxin Wu and Chen Zhu

ACS Catal., 2023, 13, 8394
DOI: 10.1021/acscatal.3c01342

Enantioselective Copper-Catalyzed Fukuyama Indole Synthesis from 2-Vinylphenyl Isocyanides

Till Drennhaus, Dirk Leifert, Jessika Lammert, Jan Philipp Drennhaus, Klaus Bergander, Constantin G. Daniliuc and Armido Studer

J. Am. Chem. Soc., 2023, 145, 8665
DOI: 10.1021/jacs.3c01667

Stereoselective Synthesis of Glycomimetics by Photocatalytic One‐Pot C(sp3)─H Acylation and Ring Contraction

Zhijun Zhou, Yuqi Ai, Sheng Xu, Xinjing Lin, Yuanyuan Ping and Wangqing Kong

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202510594

Modular Access to Nitriles From Carbonyls via Deoxygenative Transformation With Polarity Inversion

Fancong Meng, Wenhao Xu, Zhigang Wang, Yuanqiang Chen, Shuntao Xia and Tao XU

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.8039232

Copper-Catalyzed Enantioselective Three-Component Fluoroalkylalkynylation of Unactivated Alkenes

Mengxia Liao, Cuihuan Geng, Zhengze Wu, Chunxiang Pan, Chenwei Wang, Guanghui Meng, Xiaoyan Zuo, Ying Zhu, Xiaotian Qi, Guozhu Zhang and Rui Guo

ACS Catal., 2025, 15, 1693
DOI: 10.1021/acscatal.4c06641

Ligand-controlled regiodivergent and enantioselective C–H cyanation of secondary amines

Yang-Jie Mao, Xiahe Chen, Huan-Le Li, Qi Pan, Kun Zhou, Zhen-Yuan Xu, Yun-Fang Yang, Shao-Jie Lou and Dan-Qian Xu

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-68598-8

Enantioselective C(sp3)–C(sp3) Cross-Coupling between Oxacycles and Alkylsilyl Peroxides via a Dual Photoredox/Nickel Catalytic System

Jia-Hao Xie, Terumasa Kato and Keiji Maruoka

ACS Catal., 2026, 16, 5466
DOI: 10.1021/acscatal.6c00536

Precision Alkynylation of 1,3-Bis(Boronates) by Utilizing Distinct Organometallic Reagents for Regioselective Synthesis

Ang Chen, Chong-Lei Ji and De-Wei Gao

Synlett, 2024, 35, 1839
DOI: 10.1055/a-2236-5948

Copper-Mediated Three-Component Synthesis of Diverse Perfluoroalkylated Fullerenes

Si-Si Liang, Qian Zhou, Pei-Xi Wu, Xiao-Man Huang, Meng-Ping Shu, Xiao-Ming Zhu, Liang Xu and Guan-Wu Wang

J. Org. Chem., 2025, 90, 2022
DOI: 10.1021/acs.joc.4c02753

Copper-Catalyzed Asymmetric Functionalization of Vinyl Radicals for the Access to Vinylarene Atropisomers

Mengyue Li and Wenjing Xiao

Chinese Journal of Organic Chemistry, 2023, 43, 2973
DOI: 10.6023/cjoc202300043

Regioselective C(2) Methylthiolation and d3-Methylthiolation of Indoles Based on Dimethyl Sulfoxide (DMSO-d6) Reagents

Juan Zhang, Yisen Wang, Yu Tian, Jing Xu, Wenchao Gao, Honghong Chang, Fanhui Meng and Peng Yang

Chinese Journal of Organic Chemistry, 2024, 44, 1576
DOI: 10.6023/cjoc202310026

Photoinduced Copper-Catalyzed Regio- and Enantioselective Alkynylation of Epoxides

Jianye Li, Sijia Li, Guo-Hao Cui, Kaiyao Yuan, Chenwei Wang, Chen Yang, Guozhu Zhang and Rui Guo

ACS Catal., 2024, 14, 7553
DOI: 10.1021/acscatal.4c00818

Photoinduced Copper-Catalyzed Enantioselective Alkylalkynylation of Alkenes via Polarity-Matched Hydrogen Atom Transfer

Zhengze Wu, Kai Li, Mengxia Liao, Chunxiang Pan, Bin Yang, Xi Ma, Hengyu Huo, Binbin Tu, Guozhu Zhang and Rui Guo

J. Am. Chem. Soc., 2025, 147, 22072
DOI: 10.1021/jacs.5c06054

One‐Pot Reactions of Ynones with Isothiocyanates for Accessing 2‐Aminothiophenone and Indole‐Fused/Indole‐Substituted Thiophenone Derivatives

Zefeng Jin, Cuiying Li, Guodong Shen, Honglan Kang and Xin Lv

Adv Synth Catal, 2024, 366, 5151
DOI: 10.1002/adsc.202400641

Recent Developments in Copper(I)‐Catalyzed Enantioselective Alkynylation Reactions via a Radical Process

Xueling Mo, Rui Guo and Guozhu Zhang

Chin. J. Chem., 2023, 41, 481
DOI: 10.1002/cjoc.202200521

A theoretical study on the feasibility of 1,4-Copper migration in the Cu-catalyzed formal hydro(borylmethylsilyl)ation of internal alkynes

Song Liu, Wei Chen, Xinyu Long, Dianmin Zhang, Jingxu Chen, Zhou Zhu and Haobin Wei

Commun Chem, 2025, 9
DOI: 10.1038/s42004-025-01829-z

Organocatalytic C−H Functionalization of Simple Alkanes

Fen Su, Fengfei Lu, Kun Tang, Xiaokang Lv, Zhongfu Luo, Fengrui Che, Hongyan Long, Xingxing Wu and Yonggui Robin Chi

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310072

Oxidative Dehydrogenative Coupling of Thiols with Alkanes for the Synthesis of Sulfoxides

Yu-Jian Hou, Yi Li, Zhi-Wei Zhao, Tai-Gang Fan, Bo-Xun Sun, Xu-Nan Wang and Ya-Min Li

Org. Lett., 2023, 25, 517
DOI: 10.1021/acs.orglett.2c04238

Copper-Catalyzed Asymmetric Functionalization of Vinyl Radicals for the Access to Vinylarene Atropisomers

Liang Fu, Xin Chen, Wenzheng Fan, Pinhong Chen and Guosheng Liu

J. Am. Chem. Soc., 2023, 145, 13476
DOI: 10.1021/jacs.3c04498

Copper‐Mediated C4─H Selective Fluoroalkoxylation of Indoles via a Transient Directing Group Strategy

Ming‐Shun Mei and Yanghui Zhang

Chin. J. Chem., 2025, 43, 3630
DOI: 10.1002/cjoc.70310

Metallaphotoredox Enabled Single Carbon Atom Insertion into Alkenes for Allene Synthesis

Gang Liu, Zhaoxin Shi, Chuning Guo, Danyu Gu and Zhaobin Wang

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202418746

Photoinduced Copper‐Catalyzed Asymmetric C(sp3)−H Alkynylation of Cyclic Amines by Intramolecular 1,5‐Hydrogen Atom Transfer

Rui Guo, Haijing Xiao, Sijia Li, Yixin Luo, Jiahui Bai, Mengzhen Zhang, Yinlong Guo, Xiaotian Qi and Guozhu Zhang

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202208232

Enantioselective Alkoxycarbonyl‐Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis

Yuping Xiong, Zhipeng Zong, Wenlin Xie, Jian‐Qiang Chen, Xiaoyu Zhou and Jie Wu

Advanced Science, 2025, 12
DOI: 10.1002/advs.202510918

Controlled Regiodivergent Alkynylation of C—B Bond in 1,3-Bis(boronic) Esters

Du Chen and Chao Liu

Chinese Journal of Organic Chemistry, 2023, 43, 4311
DOI: 10.6023/cjoc202300069

Modular alkyl growth in amines via the selective insertion of alkynes into C–C bonds

Xin-Yue Zhou, Lu Liu, Hairong Lyu and Xiao-Chen Wang

Nat. Chem., 2025, 17, 1323
DOI: 10.1038/s41557-025-01849-1

Photoredox‐Catalyzed Decarboxylative Bromination, Chlorination and Thiocyanation Using Inorganic Salts

Jingjing Wu, Chao Shu, Zhihang Li, Adam Noble and Varinder K. Aggarwal

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202309684

Unraveling the mechanism of trifluoromethyl group transfer from Cu(I) to Cu(III)

Yifa Yang, Sheng-Ye Zhang, Yongrui Luo, Jian Wu, Xuebing Leng and Qilong Shen

Chinese Chemical Letters, 2025, 111821
DOI: 10.1016/j.cclet.2025.111821

Selective functionalization of benzylic C(sp3)–H bonds to synthesize complex molecules

Yu Zhang, Tong Zhang and Shoubhik Das

Chem, 2022, 8, 3175
DOI: 10.1016/j.chempr.2022.10.005

Copper-catalyzed reaction of aziridine for the synthesis of substituted imidazolidine and imidazolidinone

Kota Hashimoto, Daiki Higuchi, Satoshi Matsubara and Kei Murakami

Front. Chem., 2023, 11
DOI: 10.3389/fchem.2023.1272034

(Salen)Titanium‐Catalyzed Asymmetric Hydrogen Atom Transfer for Epoxides Reduction

Zhongyun Xu, Jian Shen, Longfei Li, Wanjiao Chen, Shengxiao Li, Jie Jiang and Yong‐Qiang Zhang

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202214111

Copper-Catalyzed Enantioselective Three-Component Carboamidation of Styrenes with Alkanes and Amides

Ying-Ying Chen, Ling Dai, Xuan-Ge Zhang and Qi-Lin Zhou

J. Am. Chem. Soc., 2025, 147, 12397
DOI: 10.1021/jacs.5c02348

Radical‐Based Enantioconvergent Reductive Couplings of Racemic Allenes and Aldehydes

Haigen Shen, Ling Yang, Mingrui Xu, Zhaoxin Shi, Ke Gao, Xiaowen Xia and Zhaobin Wang

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202413198

Taming radicals for stereoselective iron-catalyzed carbon–carbon bond formations

Lian-Jie Li, Dong-Song Zheng and Ze-Peng Yang

Trends in Chemistry, 2026, 8, 218
DOI: 10.1016/j.trechm.2026.01.002

Asymmetric Functionalization Harnessing Radical‐Mediated Functional‐Group Migration

Fushan Chen, Zhu Cao and Chen Zhu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202424667

Radical ligand transfer catalysis of photoexcited dinuclear gold complexes

Yaohang Cheng, Chengyihan Gu, Jie Han, Yulan Chen, Yuxi Tian, Chengjian Zhu and Jin Xie

Nat Catal, 2026, 9, 18
DOI: 10.1038/s41929-025-01462-y

Direct site-selective C(sp³)–H functionalization of unprotected non-activated alcohols

V. Aggarwal, A. Kachore, E. Bala, H. Singh, S. Malik, M. Selvaraj, M. A. Assiri, P. K. Verma and U. Sharma

RUSS CHEM REV, 2024, 93, RCR5123
DOI: 10.59761/RCR5123

Harnessing CO2 Radical Anion-Mediated Electron Transfer for Scalable Copper-Catalyzed Cross-Coupling

Shuo Wu, Chia-Jung Yang, Mu-Jeng Cheng and Wei Liu

J. Am. Chem. Soc., 2026, 148, 1717
DOI: 10.1021/jacs.5c18868

Tailored Pyridine Enables Diverse Electrochemical Benzylic C–H Functionalization

Tian‐Sheng Chen, Hua‐Xi Liu, Zi‐Can Wang, Jie‐Qing Liu, Na Chen and Hai‐Chao Xu

Angew Chem Int Ed, 2026
DOI: 10.1002/anie.9433561

O-Methyl-N-nitroisourea as a NCO Surrogate in Cu-Catalyzed Alkane C–H Amidination. A Masked Isocyanate Strategy

Jonathan Lusseau, Frédéric Robert and Yannick Landais

ACS Catal., 2023, 13, 14257
DOI: 10.1021/acscatal.3c03293

Copper‐Catalyzed Radical Allene C(sp2)−H Cyanation

Youhao Wei, Zheng Wang, Kaifeng Wang, Jiang‐Kai Qiu, Zhaoshan Wang, Haotian Li, Xiu Duan, Kai Guo, Xiaoguang Bao and Xinxin Wu

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202317132

Intermolecular Enantioselective Benzylic C(sp3)−H Amination by Cationic Copper Catalysis**

Ling Dai, Ying‐Ying Chen, Li‐Jun Xiao and Qi‐Lin Zhou

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202304427

Hydroalkylation of unactivated olefins with C(sp 3 )─H compounds enabled by NiH-catalyzed radical relay

Jiang-Ling Shi, Youcheng Wang, Yufeng Han, Jinqi Chen, Xiaolan Pu and Ying Xia

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.ads6885

Asymmetric cyanoesterification of vinylarenes by electrochemical copper catalysis

Kehan Zhou and Niankai Fu

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-62137-7

Copper/Photoredox Dual Catalysis for the Redox-Neutral C(sp3)–CF2H Cross-Coupling between Benzylic Bromides and Tetracoordinated Difluoromethylborates

Xiangxue Cao, Ge Lan, Zhenyu Wang, Shuai Liu, Yu Wei, Liang Xu and Huanhuan Song

Org. Lett., 2026, 28, 2188
DOI: 10.1021/acs.orglett.6c00060

Chiral Bis(binaphthyl) Cyclopentadienyl Ligands for Rhodium-Catalyzed Desymmetrization of Diarylmethanes via Selective Arene Coordination

Wen-Qiang Wu, Pei-Pei Xie, Le-Yao Wang, Bo-Bo Gou, Yunzhi Lin, Li-Wei Hu, Chao Zheng, Shu-Li You and Hang Shi

J. Am. Chem. Soc., 2024, 146, 26630
DOI: 10.1021/jacs.4c10876

Cyclization Through Dual C(sp3)−H Functionalization

Masoud Sadeghi

Adv Synth Catal, 2024, 366, 3542
DOI: 10.1002/adsc.202400762

Copper-Mediated C4–H Sulfonylation of Indoles via a Transient Directing Group Strategy

Ming-Shun Mei, Fanyi Meng, Junhao Tang, Dongsheng Yi and Yanghui Zhang

Org. Lett., 2025, 27, 9710
DOI: 10.1021/acs.orglett.5c02916

Copper-Catalyzed Benzylic C–H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space

Si-Jie Chen, Shane W. Krska and Shannon S. Stahl

Acc. Chem. Res., 2023, 56, 3604
DOI: 10.1021/acs.accounts.3c00580

Site‐Selective α─C─H Functionalization of Saturated Heterocycles via Copper‐Photoredox Catalysis

Yi Lu, Ya‐Jing Chen, Xu‐Bing Li, Xiaodong Yang, Li‐Zhu Wu and Hongbin Zhang

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202508093

Stereoselective Radical Cross-Coupling of Amino Acids and Imines via Hydrogen-Bond Catalysis

Wen Shu, Wenxu Cao, Suping Zhang, Haihui Huang, Xiaorong Song, Pengli Zhang and Guoqin Xia

ACS Catal., 2025, 15, 21033
DOI: 10.1021/acscatal.5c07372

Copper-Catalyzed Site-Selective C(sp2)–H Alkynylation of Allenes

Xiu Duan, Qihao Jin, Kaifeng Wang, Yifan Sun, Youhao Wei, Zheng Wang, Jiang-Kai Qiu, Kai Guo, Xiaoguang Bao and Xinxin Wu

ACS Catal., 2024, 14, 13219
DOI: 10.1021/acscatal.4c03688

Unveiling mechanistic patterns of copper-catalyzed radical bond formation through linear free energy relationship

Guo-Xiong Xu, Ji-Ren Liu, Zeng Gao, Miao-Jiong Tang, Yi-Zhou Sun, Zhong-Liang Li, Xin-Yuan Liu, Shuo-Qing Zhang and Xin Hong

Nat Commun, 2025, 17
DOI: 10.1038/s41467-025-67770-w

Controllable Regiodivergent Alkynylation of 1,3‐Bis(Boronic) Esters Activated by Distinct Organometallic Reagents

Ang Chen, Yang Qiao and De‐Wei Gao

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202312605

Nickel-catalysed enantioselective migratory reductive cross-coupling enabled by radical 1,2-amino migration

Xiaolin Ren, Yiwei Qiao, Bingqi Zhou, Song Liu and Yuan Huang

Nat. Synth, 2025, 4, 1232
DOI: 10.1038/s44160-025-00840-5

Fluoroamide-Directed Regiodivergent C-Alkylation of Nitroalkanes

Zhibin Du, Shiwen Liu, Yuke Li, Junjie Peng, Yanji Sun, Yanshan Song, Yuxuan Liu and Xiaojun Zeng

Org. Lett., 2023, 25, 4632
DOI: 10.1021/acs.orglett.3c01297

Research progress on visible-light-induced C–H functionalization reactions catalyzed by covalent organic frameworks

Yu Chen, Yuezhu Qi, Runzhe Wu, Yitong Pan, Guoqing Huang, Ming Yang, Xiubin Bu, Xiaobo Yang and Zhen Zhao

Sci. Sin.-Chim, 2025, 55, 1879
DOI: 10.1360/SSC-2024-0266