Radical cascade cyclization of 1,n-enynes under photo/electrochemical conditions

Abstract

During the past decade, photo- and electrochemical reactions proceeding via single-electron-transfer (SET) triggered radical pathways have emerged as an indispensable strategy for the efficient formation of chemical bonds. Especially, radical cyclization reactions of 1,n-enynes are widely explored to the synthesis of valuable carbo- and heterocycles, which are ubiquitous in bioactive compounds thus highlighting their relevance. Notably, exceedingly mild conditions usually associated with this kind of chemical transformation enable the modification of multi-functional substrates yielding complex molecular scaffolds. This minireview highlights recent progress in radical cascade cyclizations of 1,n-enynes (n = 5, 6 and 7) under photo/electrochemical conditions until September 2023. We classified the content of the review according to the type of substrates or products in order to offer a better overview and understanding to the readership, hoping this work will exhibit the breath and power of emerging photo- and electrochemical methods in radical chemistry.