Issue 12, 2021

Erythrocyte-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections

Abstract

Bioorthogonal transformation of imaging and therapeutic substrates using transition metal catalysts (TMCs) provides a toolkit with diverse applications in biomedicine. Controlled localization of bioorthogonal catalysis is key for enhancing their therapeutic efficacy by minimizing off-target effects. Red blood cells (RBCs) are highly biocompatible and are susceptible to hemolysis by bacterial toxins, providing them with intrinsic targeting to bacterial infections. A hitchhiking strategy using RBCs is reported, that activates bioorthogonal catalysis at infection sites. A library of nanoparticles embedded with TMCs (nanozymes) featuring diverse functional groups with different binding ability to RBCs is generated. These engineered nanozymes bind to RBCs and subsequently release upon hemolysis by bacterial toxins, resulting in selective accumulation at the site of bacterial infections. The antimicrobial action is specific: catalytic activation of pro-antibiotics eradicated pathogenic biofilms without harming non-virulent bacterial species.

Graphical abstract: Erythrocyte-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections

Supplementary files

Article information

Article type
Communication
Submitted
31 अगस्त 2021
Accepted
14 अक्तूबर 2021
First published
26 अक्तूबर 2021

Mater. Horiz., 2021,8, 3424-3431

Erythrocyte-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections

A. Gupta, R. Das, J. M. Makabenta, A. Gupta, X. Zhang, T. Jeon, R. Huang, Y. Liu, S. Gopalakrishnan, R. Milán and V. M. Rotello, Mater. Horiz., 2021, 8, 3424 DOI: 10.1039/D1MH01408K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements