Issue 16, 2021

Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

Abstract

The transformation of the piroxicam monohydrate to form I or form II could be achieved precisely by adjusting the particle size itself in a 99% acetone-1% H2O solvent at 31 °C. Mechanistic studies have demonstrated that the particle size could affect both the maximum concentration of piroxicam and the heterogeneous nucleation of form II during the solution-mediated phase transformation (SMPT) process, finally determining the polymorph outcome.

Graphical abstract: Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

Supplementary files

Article information

Article type
Communication
Submitted
18 फरवरी 2021
Accepted
20 मार्च 2021
First published
22 मार्च 2021

CrystEngComm, 2021,23, 2928-2932

Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

C. Yao, L. Wang, X. Wang and X. Tao, CrystEngComm, 2021, 23, 2928 DOI: 10.1039/D1CE00237F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements