Issue 48, 2021

Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

Abstract

In recent years, the increasing occurrence of microbial resistance to biocidal materials has become a serious problem. In contrast to other biocides, iodine seems to have no real resistance issue, but its instability causes pain and irritation. The metal–organic framework Zr6O4(OH)4(BTC)2(HCOO)6 (MOF-808) is a highly thermally and chemically stable Zr-MOF synthesized from trimesic acid (H3BTC). H3BTC is a highly electron-deficient molecule that seems to make MOF-808 an appropriate adsorbent of non-polar iodine. Herein, activated MOF-808 was synthesized for caging the biocide, iodine. The obtained samples were characterized by FT-IR spectroscopy, PXRD, TGA, SEM, TEM, ZP and BET analyses. The adsorbed amount of iodine on the iodine-loaded MOF-808 (I2@MOF-808) was estimated by thermogravimetric analyses (25.3%) and UV-vis spectroscopy (27.0%). Finally, its antibacterial activity was evaluated against S. aureus and E. coli with a reported 19 mm zone of inhibition for I2@MOF-808 against S. aureus. Therefore, I2@MOF-808 can be considered as a biocide that does not have the microbial resistance problem and also problems caused by the instability of iodine.

Graphical abstract: Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

Supplementary files

Article information

Article type
Paper
Submitted
05 जनवरी 2021
Accepted
24 अक्तूबर 2021
First published
26 अक्तूबर 2021

CrystEngComm, 2021,23, 8538-8545

Biocompatible MOF-808 as an iodophor antimicrobial agent with controlled and sustained release of iodine

M. Nakhaei, K. Akhbari and A. Davoodi, CrystEngComm, 2021, 23, 8538 DOI: 10.1039/D1CE00019E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements