Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone†‡§

Liming Cao,a   John P. Maciejewski,a   Stephan Elzner,a   David Amantinia  and  Peter Wipf*a  

* Corresponding authors

a Department of Chemistry and Center for Chemical Methodologies and Library Development, 219 Parkman Avenue, 15260 Pittsburgh, PA, USA
E-mail: pwipf@pitt.edu
Fax: +1 412 624 0787
Tel: +1 412 624 8606

Abstract

The intramolecular Staudinger-aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic product was confirmed by X-ray analysis.

Graphical abstract: Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25353D
Article type
Communication
Submitted
20 फरवरी 2012
Accepted
19 मार्च 2012
First published
20 मार्च 2012

Org. Biomol. Chem., 2012,10, 5811-5814

Permissions

Request permissions

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone

L. Cao, J. P. Maciejewski, S. Elzner, D. Amantini and P. Wipf, Org. Biomol. Chem., 2012, 10, 5811 DOI: 10.1039/C2OB25353D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements