The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

Braja Gopal Das; Prasanta Ghorai

doi:10.1039/C2CC33185C

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The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re₂O₇ catalyst†

Braja Gopal Das^a and Prasanta Ghorai*^a

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^a Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal-462023, India
E-mail: pghorai@iiserb.ac.in
Fax: +91 7554092329
Tel: +91 7554092325

Abstract

An unprecedented direct reductive amination of electron-deficient amines such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO₂-, Ar₂PO-, etc. protected amines with aldehydes is achieved using the Re₂O₇ catalyst and silanes as the hydride source. Excellent regioselective mono-alkylation and chemoselective reductive-amination were observed.

This article is part of the themed collection: 20th Anniversary of the CRSI: Celebrating Indian Chemistry in ChemComm

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Article information

DOI: https://doi.org/10.1039/C2CC33185C
Article type: Communication
Submitted: 03 मई 2012
Accepted: 02 जुलाई 2012
First published: 02 जुलाई 2012

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Chem. Commun., 2012,48, 8276-8278

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The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re₂O₇ catalyst

B. G. Das and P. Ghorai, Chem. Commun., 2012, 48, 8276 DOI: 10.1039/C2CC33185C

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