Issue 2, 2010
From the journal:

Chemical Communications

Stereoselective synthesis of trans-β-lactams by palladium-catalysed carbonylation of vinyl aziridines†‡

Francesco Fontana,ab   Gian Cesare Tron,a   Nekane Barbero,a   Serena Ferrini,a   Stephen P. Thomasa  and  Varinder K. Aggarwal*a  

* Corresponding authors

a School of Chemistry, Cantock’s Close, Bristol, UK
E-mail: V.Aggarwal@bristol.ac.uk
Fax: +44 (0)117 929 8611
Tel: +44 (0)117 954 6315

b Università degli Studi di Milano, Dipartimento di Chimica Organica e Industriale, Via Venezian 21, Milano, Italy

Abstract

The palladium-catalysed carbonylation of vinyl aziridines can give either the trans- or cis-β-lactam preferentially or even the δ-lactam simply by adjusting the reaction parameters ([Pd], [CO], temperature).

Graphical abstract: Stereoselective synthesis of trans-β-lactams by palladium-catalysed carbonylation of vinyl aziridines

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Article information

DOI
https://doi.org/10.1039/B920564K
Article type
Communication
Submitted
05 अक्तूबर 2009
Accepted
13 नवम्बर 2009
First published
27 नवम्बर 2009

Chem. Commun., 2010,46, 267-269

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Stereoselective synthesis of trans-β-lactams by palladium-catalysed carbonylation of vinyl aziridines

F. Fontana, G. C. Tron, N. Barbero, S. Ferrini, S. P. Thomas and V. K. Aggarwal, Chem. Commun., 2010, 46, 267 DOI: 10.1039/B920564K

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